Article
Pharmacology & Pharmacy
Luqman Vali, David R. Jenkins, Rakesh Vaja, Hussain Mulla
Summary: The study demonstrated that bedside Bayesian-guided personalised dosing of vancomycin in vascular surgery patients can increase the proportion of patients achieving target AUC(24) values and the percentage time in the target range.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kai Shen, Yaxin Fan, Minjie Yang, Yuancheng Chen, Jinhao Tao, Guoping Lu, Hong Zhang, Qiwei Huang, Jing Zhang
Summary: This study aimed to establish a population pharmacokinetics model for Chinese pediatric patients receiving Vancomycin and evaluate the correlation between PK/PD indices and clinical outcomes. The results showed no significant correlation between PK/PD indices and clinical efficacy, suggesting that Chinese pediatric patients may be suitable for a lower AUC(0-24)/MIC target value. Further studies are needed to explore optimal dose regimens for Chinese pediatric patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Sean N. Avedissian, Gwendolyn Pais, Jiajun Liu, J. Nicholas O'Donnell, Thomas P. Lodise, Michael Neely, Walter C. Prozialeck, Peter C. Lamar, Leighton Becher, Marc H. Scheetz
Summary: The study identified that in a rat model, both the dosage and frequency of vancomycin administration significantly influenced the risk of kidney injury, with exposure-response relationships observed between pharmacokinetic exposure and kidney injury molecule-1 levels.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Microbiology
Bruce R. Dalton
Summary: Therapeutic drug monitoring for vancomycin has shifted its focus from trough concentrations to area under the curve (AUC(24)). However, the evidence for this change is weak, with retrospective analyses and animal studies lacking conviction. In vitro data also present conflicting results. Therefore, the adoption of AUC(24):MIC based on animal experiments and in vitro evidence may be premature for vancomycin.
Article
Immunology
Thomas P. Lodise, Marc Scheetz, Joseph J. Carreno, Henry Chambers, Vance Fowler, Thomas L. Holland
Summary: In patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased with higher day 2 area under the curve (AUC), even when daily AUCs were within the recommended therapeutic range (400-600). Further data is needed to assess if daily AUCs <400 can be maintained without compromising efficacy.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Qingxia Liu, Huiping Huang, Baohua Xu, Dandan Li, Maobai Liu, Imam H. Shaik, Xuemei Wu
Summary: The revised guidelines recommend maintaining the AUC/MIC of vancomycin at 400-600 mg·h/L as the target for efficacy. Two new methods for estimating AUC at steady state using multiple levels after the first dose can help achieve the effective target from the third or fourth dose.
Article
Infectious Diseases
Sho Tashiro, Kazuaki Taguchi, Yuki Enoki, Kazuaki Matsumoto
Summary: A feces-based PK/PD analysis method was developed to determine the fecal PK/PD index and target values of fidaxomicin (FDX) and vancomycin (VCM) against Clostridioides difficile infection (CDI).
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Computer Science, Information Systems
June Young Chun, Kyoung-Ho Song, Dong-eun Lee, Joo-Hee Hwang, Hyun Gul Jung, Eunjeong Heo, Hyung-sook Kim, Seonghae Yoon, Jeong Su Park, Pyoeng Gyun Choe, Jae-Yong Chung, Wan Beom Park, Ji Hwan Bang, Hee Hwang, Kyoung-Un Park, Sang Won Park, Nam Joong Kim, Myoung-don Oh, Eu Suk Kim, Hong Bin Kim
Summary: The introduction of the Vancomycin CDSS did not increase nephrotoxicity and resulted in higher mean initial doses and trough levels of vancomycin. In the vancomycin loading group, the mean initial trough level was 11.95 mg/L, compared to 7.55 mg/L in the non-loading group. The main reason for not prescribing a vancomycin loading dose was concern about nephrotoxicity.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2021)
Review
Pharmacology & Pharmacy
Qile Xiao, Hainan Zhang, Xiaomei Wu, Jian Qu, Lixia Qin, Chunyu Wang
Summary: Vancomycin, a hydrophilic antibiotic, is widely used for severe infections. However, predicting vancomycin exposure in serum and cerebrospinal fluid (CSF) is challenging due to changing pathophysiological processes and patient-specific factors. Studies on vancomycin's pharmacokinetics (PK) in CSF are limited, making it difficult to achieve adequate antimicrobial therapy. Accurate prediction and optimization of vancomycin pharmacokinetics/pharmacodynamics (PK/PD) are critical for effective treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pediatrics
Bo Zhou, Wenyi Xiong, Ke Bai, Hongxing Dang, Jing Li, Feng Xu, Yue-qiang Fu, Chengjun Liu
Summary: This study aimed to evaluate the efficacy and safety of vancomycin in children with severe infection in the Pediatric Intensive Care Unit (PICU) and determine the appropriate threshold to avoid nephrotoxicity. The results showed that the trough concentration and AUC(0-24) of vancomycin were closely related to vancomycin-related nephrotoxicity, while no significant correlations were found with therapeutic efficacy. The combination of AUC(0-24) and trough concentration for therapeutic drug monitoring may reduce the risk of nephrotoxicity.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Manal Abouelkheir, Abdullah Almohaizeie, Abdulrahman Almutairi, Sara Almuhisen, Saeed Alqahtani, Abdullah Alsultan
Summary: This study evaluated the use of a population pharmacokinetic model-based approach for optimizing vancomycin initial dosing in neonates. The results showed that the model-based method had a higher probability of achieving the recommended therapeutic target compared to empirical dosing based on other references.
PEDIATRICS AND NEONATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Amadou Samb, Rimke De Kroon, Koos Dijkstra, Marre Van Den Brand, Martine Bos, Frank Van Den Dungen, Agnes Veldkamp, Bram Wilhelm, Timo R. De Haan, Yuma A. Bijleveld, Marceline Tutu Van Furth, Paul Savelkoul, Noortje Swart, Ron Mathot, Mirjam Van Weissenbruch
Summary: This study investigates the feasibility of using real-time quantitative polymerase chain reaction (RT-qPCR) to quantify bacterial DNA loads (BDLs) for assessing treatment efficacy of vancomycin in late-onset sepsis (LOS). Serial blood samples were collected from premature and very low birth weight (VLBW) newborns, and BDLs were measured using RT-qPCR. Population pharmacokinetic-pharmacodynamic modeling was performed to describe the relationship between vancomycin concentration and BDL elimination rate, and it was found that treatment response to vancomycin can be assessed as early as 8 hours after treatment initiation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Sinenhlanhla Mtshali, Byron A. Jacobs
Summary: Physiologically based pharmacokinetic models have gained popularity in drug development and regulatory science. This study validates the model's effectiveness in predicting drug-drug interaction and the pharmacokinetics of antiretroviral and anti-TB drugs through mathematical solving and sensitivity analysis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Pei Le Wang, Peng Liu, Qi Wen Zhang, Wen Hua Yuan, Dao Wang, Xiao Jian Zhang, Jing Yang
Summary: This study developed a population pharmacokinetic model for polymyxin B in pediatric patients and evaluated different dosages. The results suggest that current dosing for pediatric patients may be acceptable in certain situations and the minimum inhibitory concentration of the infecting pathogens should be considered.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Franziska Schneider, Andre Gessner, Nahed El-Najjar
Summary: The current antimicrobial therapy for bacterial infections of the central nervous system (CNS) in adults and pediatric patients faces challenges in achieving necessary drug levels in serum and crossing the blood-brain barrier. Factors such as the structure of the antimicrobial agent, disease severity, and inflammation play significant roles. Despite attempts to establish pharmacokinetic modeling for dosing regimens, conclusive recommendations for the best therapeutic strategies are lacking. This review focuses on the use of vancomycin and meropenem in managing CNS infections in adults and pediatric patients, aiming to summarize the current pitfalls and success of therapy, and emphasize the need for more studies to improve clinical outcomes.
Letter
Immunology
Lindsay M. Avery, Joseph L. Kuti, Maja Weisser, Adrian Egli, Michael J. Rybak, Evan J. Zasowski, Cesar A. Arias, German A. Contreras, Pearlie P. Chong, Samuel L. Aitken, Adam J. DiPippo, Jann-Tay Wang, Nicholas S. Britt, David P. Nicolau
CLINICAL INFECTIOUS DISEASES
(2019)
Retraction
Immunology
Evan J. Zasowski, Trang D. Trinh, Safana M. Atwan, Marina Merzlyakova, Abdalhamid M. Langf, Sahil Bhatia, Michael J. Rybak
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Health Care Sciences & Services
Hamed Kianmehr, Nasim S. Sabounchi, Shabnam Seyedzadeh Sabounchi, Leon E. Cosler
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2020)
Article
Microbiology
Sarah C. J. Jorgensen, Trang D. Trinh, Evan J. Zasowski, Abdalhamid M. Lagnf, Samuel P. Simon, Sahil Bhatia, Sarah M. Melvin, Molly E. Steed, Natalie A. Finch, Taylor Morrisette, Sandy J. Estrada, Joshua R. Rosenberg, Susan L. Davis, Michael J. Rybak
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Immunology
Erin K. McCreary, Ravina Kullar, Matthew Geriak, Evan J. Zasowski, Khulood Rizvi, Lucas T. Schulz, Krista Ouellette, Logan Vasina, Fadi Haddad, Michael J. Rybak, Marcus J. Zervos, George Sakoulas, Warren E. Rose
OPEN FORUM INFECTIOUS DISEASES
(2020)
Review
Infectious Diseases
Matteo Bassetti, Jordi Rello, Francesco Blasi, Herman Goossens, Giovanni Sotgiu, Lara Tavoschi, Evan J. Zasowski, Mick R. Arber, Rachael McCool, Jacoby Patterson, Christopher M. Longshaw, Sara Lopes, Davide Manissero, Sean T. Nguyen, Keiko Tone, Stefano Aliberti
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2020)
Article
Public, Environmental & Occupational Health
Nicole Hassoun, Jacob Friedman, Leon E. Cosler
Summary: A mathematical model is used to evaluate the health impact of medicines on diseases, providing information for health policy and scientific research. The latest model shows that key drugs have saved approximately 62 million life-years in malaria, TB, HIV/AIDS, and NTDs treatment. However, the burden of diseases is evenly distributed among malaria, TB, and HIV/AIDS in the absence of treatment. Establishing a standardized framework for health impact can help identify global shortcomings.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2022)
Article
Immunology
Evan J. Zasowski, Trang D. Trinh, Kimberly C. Claeys, Abdalhamid M. Lagnf, Sahil Bhatia, Kenneth P. Klinker, Michael P. Veve, Sandy J. Estrada, Scott T. Johns, Adam J. Sawyer, Vanthida Huang, Brandi LaFrance, Donald P. Levine, Keith S. Kaye, Susan L. Davis, Michael J. Rybak
Summary: This study compares the outcomes of MRSA bloodstream infection treated with ceftaroline or daptomycin. The results show no difference in treatment failure or mortality between the two antibiotics. Ceftaroline may be considered as a primary treatment for MRSA bloodstream infection and can be used as an alternative to vancomycin and daptomycin.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Nicole Hassoun, Leon Cosler
Summary: Neglected tropical diseases (NTDs) have a significant impact on lifespan and livelihood, but receive little research and development. Using existing data on treatment effectiveness, our models estimate that in 2015, NTD treatments averted 2,778,131.78 disability-adjusted life years (DALYs). Treatments targeting soil-transmitted helminths accounted for the majority of DALYs averted, followed by schistosomiasis, lymphatic filariasis, and onchocerciasis.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Pharmacology & Pharmacy
Danial A. Chowdhury, Min Sun Jeong, Lakhini Vyas, Jonathan Kim, Leon E. Cosler, Devon J. Lash, Joseph A. Barone, Michael Toscani, Lucio R. Volino
Summary: This study evaluated the temperature fluctuations during mail transit and found that package temperatures were often outside of the recommended range regardless of the shipping method, carrier, or season.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Sarah Lynch, Caleigh Garton, Jennifer Fiscus, Stephanie Kovnat, Claudia Woznicki, Humyra Ali, Leon E. Cosler
Summary: This study aimed to investigate the experiences, perceptions, and knowledge of New York State women regarding access to and use of hormonal contraceptives. The survey results showed that most respondents were accepting of pharmacists initiating contraceptive use, but there is room for improvement in patient education and experience. Direct pharmacy access to hormonal contraceptives may help eliminate some barriers.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2023)
Article
Infectious Diseases
Evan J. Zasowski, Maryam Ali, Ada Anugo, Nayle Ibragimova, Kierra M. Dotson, Bradley T. Endres, Khurshida Begum, M. Jahangir Alam, Kevin W. Garey
Summary: This study aimed to develop predictive indices for multidrug-resistant organism (MDRO) gut colonization in patients with Clostridioides difficile infection (CDI). They compared the predictive performance of a regression-based risk score with two other simplified risk stratification approaches. The results showed that a simplified approach using prior healthcare exposure and receipt of prior antibiotics was as effective as individual patient/antibiotic risk modeling in identifying patients at risk for MDRO gut colonization.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Infectious Diseases
Sara Alosaimy, Noor L. Sabagha, Abdalhamid M. Lagnf, Evan J. Zasowski, Taylor Morrisette, Sarah C. J. Jorgensen, Trang D. Trinh, Ryan P. Mynatt, Michael J. Rybak
INFECTIOUS DISEASES AND THERAPY
(2020)
Article
Infectious Diseases
Sarah C. J. Jorgensen, Trang D. Trinh, Evan J. Zasowski, Abdalhamid M. Lagnf, Sahil Bhatia, Sarah M. Melvin, Samuel P. Simon, Joshua R. Rosenberg, Molly E. Steed, Sandra J. Estrada, Taylor Morrisette, Susan L. Davis, Michael J. Rybak
INFECTIOUS DISEASES AND THERAPY
(2020)
Review
Dentistry, Oral Surgery & Medicine
Sepideh Seyedzadeh Sabounchi, Shabnam Seyedzadeh Sabounchi, Leon E. Cosler, A. Serdar Atav
QUINTESSENCE INTERNATIONAL
(2020)