Article
Pharmacology & Pharmacy
Maytham Hussein, Rafah Allobawi, Irini Levou, Mark A. T. Blaskovich, Gauri G. Rao, Jian Li, Tony Velkov
Summary: Polymyxins combined with synthetic cannabidiol showed synergistic antibacterial activity against both polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii isolates. Metabolomics study revealed that the combination therapy significantly perturbed metabolic pathways involved in bacterial cell envelope and membrane lipids. The study suggests the possibility of cannabidiol repositioning, in combination with polymyxins, for treatment of multidrug-resistant Gram-negative infections.
Article
Microbiology
Ryan Waite, Candace T. Adams, David R. Chisholm, C. H. Cole Sims, Joshua G. Hughes, Eva Dias, Emily A. White, Kathryn Welsby, Stanley W. Botchway, Andrew Whiting, Gary J. Sharples, Carrie A. Ambler
Summary: The emergence of antibiotic resistance poses a growing threat to human health, and the search for alternatives is urgent. A new fluorescent photoactivatable diarylacetylene has been discovered, showing a preference for eliminating Gram-positive bacteria. Experimental evidence suggests that the outer surface of Gram-negative bacteria and oxidative damage repair pathways affect the sensitivity and antibacterial activity of this compound. This new finding holds promise for the treatment of skin infections.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Usman Abubakar, Menier Al-Anazi, Zainab Alanazi, Jesus Rodriguez-Bano
Summary: The COVID-19 pandemic has led to changes in the rate of multidrug resistant gram positive and gram negative bacteria. Studies have shown an increase in MRSA and VRE infection/colonization rates, while ESBL E. coli and ESBL Klebsiella pneumoniae rates have decreased. Overall, there has been an increase in the rate of multidrug resistant CRE infection/colonization during the pandemic, while the rate of CRPA infection has decreased.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Microbiology
Ana Silva-Dias, Blanca Perez-Viso, Ines Martins-Oliveira, Rosario Gomes, Acacio G. Rodrigues, Rafael Canton, Cidalia Pina-Vaz
Summary: The FASTinov flow cytometry kits were assessed in two locations for direct evaluation, demonstrating high sensitivity for positive blood cultures and the ability to provide rapid and personalized antibiotic management.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Infectious Diseases
David M. P. De Oliveira, Bernhard Keller, Andrew J. Hayes, Cheryl-Lynn Y. Ong, Nichaela Harbison-Price, Ibrahim M. El-Deeb, Gen Li, Nadia Keller, Lisa Bohlmann, Stephan Brouwer, Andrew G. Turner, Amanda J. Cork, Thomas R. Jones, David L. Paterson, Alastair G. McEwan, Mark R. Davies, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker
Summary: The combination of PBT2 with zinc has been shown to break intrinsic polymyxin resistance in various Gram-positive bacteria and could potentially be an effective treatment against streptococcal skin infections.
Article
Polymer Science
Abdechakour Elkihel, Charlotte Vernisse, Tan-Sothea Ouk, Romain Lucas-Roper, Vincent Chaleix, Vincent Sol
Summary: This study presents a synthesis method for light-triggered antibacterial hydrogels based on xylan chains chemically bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). TCPP not only acts as an efficient photosensitizer against Gram-positive bacteria, but also serves as a cross-linking agent for the hydrogels. The hydrogels were characterized using infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and swelling and rheological tests. Under visible light irradiation, the hydrogels showed interesting antimicrobial activity against Staphylococcus aureus and Bacillus cereus, suggesting their potential for the treatment of skin bacterial infections through photodynamic antimicrobial chemotherapy (PACT).
Article
Infectious Diseases
Nuhamin Melaku Gebremariam, Adane Bitew, Estifanos Tsige, Daniel Woldesenbet, Mekdes Alemu Tola
Summary: The study revealed high levels of antimicrobial resistance and multi-drug resistance in Gram-positive cocci, highlighting the importance of ongoing monitoring of resistance patterns for selecting appropriate drugs for treatment and infection prevention.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Nanoscience & Nanotechnology
Wenyi Li, Sara Hadjigol, Alicia Rasines Mazo, James Holden, Jason Lenzo, Steven J. Shirbin, Anders Barlow, Sadegh Shabani, Tao Huang, Eric C. Reynolds, Greg G. Qiao, Neil M. O'Brien-Simpson
Summary: Antibiotic resistance in Gram-positive bacteria is becoming a global health crisis, and the lack of new antibiotics necessitates the development of novel antimicrobial materials. The study demonstrates the preferential targeting and killing of Gram-positive pathogens by star-peptide polymers, with the eight-armed structure exhibiting the highest bactericidal activity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Medicinal
Eman M. E. Dokla, Nader S. Abutaleb, Sandra N. Milik, Ezzat A. E. A. Kandil, Omar M. Qassem, Yehia Elgammal, Maha Nasr, Martin J. McPhillie, Khaled A. M. Abouzid, Mohamed N. Seleem, Peter Imming, Mai Adel
Summary: Antibiotic-resistant bacteria pose a serious threat to modern medicine and human life. A study has found that compound 25d, a novel benzimidazole derivative, exhibits potent antibacterial activity against tolC-mutant Escherichia coli without significant cytotoxicity to mammalian cells. Formulation of compound 25d as lipidic nanoparticles further enhances its antibacterial activity against Gram-negative bacterial strains.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Chao Zhong, Fangyan Zhang, Ningyi Zhu, Yuewen Zhu, Jia Yao, Sanhu Gou, Junqiu Xie, Jingman Ni
Summary: The new ultra-short lipopeptides demonstrate selectivity to bacterial membranes, low cytotoxicity, synergistic antimicrobial activity with antibiotics against resistant bacteria, rapid killing kinetics, strong anti-biofilm ability, and significant anti-inflammatory effects in vivo. These lipopeptides are considered as novel antimicrobial alternatives for combating the imminent crisis of antimicrobial resistance.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Veterinary Sciences
Amjad Islam Aqib, Abdullah F. Alsayeqh
Summary: The revolutionization of food production and processing to meet the growing human population has led to both benefits and threats, with the emergence of vancomycin resistance gene posing risks to antibiotic efficacy and food safety.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Infectious Diseases
John E. Ekakoro, Lynn Guptill, Kenitra Hendrix, Melinda Anderson, Audrey Ruple
Summary: Non-judicious antimicrobial use in veterinary hospitals in the United States is limited, and there are no guidelines or standardized methods for constructing antibiograms in veterinary clinical settings. This article describes the methods used to construct antibiograms from clinical samples collected from dogs seen at a veterinary teaching hospital. The approaches described could be useful in guiding veterinary antibiogram development for empiric therapy.
Article
Chemistry, Multidisciplinary
Alina-Viorica Iancu, Manuela Arbune, Eliza-Andreea Zaharia, Dana Tutunaru, Nicoleta-Maricica Maftei, Lucian-Daniel Peptine, George Tocu, Gabriela Gurau
Summary: The study aimed to identify the antimicrobial resistance profile of enterococci species isolated from patients in three hospitals in Romania. The antimicrobial resistance was retrospectively evaluated between 2019 and 2021 in various biological samples. Classic methods of bacteria culture and automatic identification were used for microbiological diagnosis, while sensitivity testing was performed by the Kirby-Bauer method and minimum inhibitory concentration was tested by the Vitek system.
APPLIED SCIENCES-BASEL
(2023)
Review
Public, Environmental & Occupational Health
Emily Smout, Navaneethan Palanisamy, Sabeel P. Valappil
Summary: VRE infections have been recurrently reported in different parts of India in the last two decades. However, there is limited up-to-date information concerning the prevalence and rate of VRE in India. This study aimed to estimate the pooled prevalence of VRE in India.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Microbiology
Shawna McCallin, Carmen Menzi, Swenja Lassen, Jean Daraspe, Frank Oechslin, Philippe Moreillon
Summary: In Vancomycin-intermediate Staphylococcus aureus (VISA), exposure to vancomycin may lead to cross-resistance to phage. VISA strains with intermediate levels of vancomycin resistance showed decreased sensitivity to phage. Serial passaging with vancomycin induced reduced vancomycin susceptibility and phage sensitivity. Understanding the interference between antibiotic and phage resistance mechanisms is important for designing effective therapeutic regimens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Lindsay M. Avery, Joseph L. Kuti, Maja Weisser, Adrian Egli, Michael J. Rybak, Evan J. Zasowski, Cesar A. Arias, German A. Contreras, Pearlie P. Chong, Samuel L. Aitken, Adam J. DiPippo, Jann-Tay Wang, Nicholas S. Britt, David P. Nicolau
CLINICAL INFECTIOUS DISEASES
(2019)
Letter
Immunology
Lindsay M. Avery, Joseph L. Kuti, Maja Weisser, Adrian Egli, Michael J. Rybak, Evan J. Zasowski, Cesar A. Arias, German A. Contreras, Pearlie P. Chong, Samuel L. Aitken, Adam J. DiPippo, Jann-Tay Wang, Nicholas S. Britt, David P. Nicolau
CLINICAL INFECTIOUS DISEASES
(2019)
Retraction
Immunology
Evan J. Zasowski, Trang D. Trinh, Safana M. Atwan, Marina Merzlyakova, Abdalhamid M. Langf, Sahil Bhatia, Michael J. Rybak
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Immunology
Evan J. Zasowski, Trang D. Trinh, Safana M. Atwan, Marina Merzlyakova, Abdalhamid M. Langf, Sahil Bhatia, Michael J. Rybak
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Microbiology
Sarah C. J. Jorgensen, Trang D. Trinh, Evan J. Zasowski, Abdalhamid M. Lagnf, Samuel P. Simon, Sahil Bhatia, Sarah M. Melvin, Molly E. Steed, Natalie A. Finch, Taylor Morrisette, Sandy J. Estrada, Joshua R. Rosenberg, Susan L. Davis, Michael J. Rybak
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Immunology
Sarah C. J. Jorgensen, Trang D. Trinh, Evan J. Zasowski, Abdalhamid M. Lagnf, Sahil Bhatia, Sarah M. Melvin, Molly E. Steed, Samuel P. Simon, Sandra J. Estrada, Taylor Morrisette, Kimberly C. Claeys, Joshua R. Rosenberg, Susan L. Davis, Michael J. Rybak
OPEN FORUM INFECTIOUS DISEASES
(2019)
Review
Infectious Diseases
Matteo Bassetti, Jordi Rello, Francesco Blasi, Herman Goossens, Giovanni Sotgiu, Lara Tavoschi, Evan J. Zasowski, Mick R. Arber, Rachael McCool, Jacoby Patterson, Christopher M. Longshaw, Sara Lopes, Davide Manissero, Sean T. Nguyen, Keiko Tone, Stefano Aliberti
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2020)
Article
Immunology
Evan J. Zasowski, Trang D. Trinh, Kimberly C. Claeys, Abdalhamid M. Lagnf, Sahil Bhatia, Kenneth P. Klinker, Michael P. Veve, Sandy J. Estrada, Scott T. Johns, Adam J. Sawyer, Vanthida Huang, Brandi LaFrance, Donald P. Levine, Keith S. Kaye, Susan L. Davis, Michael J. Rybak
Summary: This study compares the outcomes of MRSA bloodstream infection treated with ceftaroline or daptomycin. The results show no difference in treatment failure or mortality between the two antibiotics. Ceftaroline may be considered as a primary treatment for MRSA bloodstream infection and can be used as an alternative to vancomycin and daptomycin.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Evan J. Zasowski, Maryam Ali, Ada Anugo, Nayle Ibragimova, Kierra M. Dotson, Bradley T. Endres, Khurshida Begum, M. Jahangir Alam, Kevin W. Garey
Summary: This study aimed to develop predictive indices for multidrug-resistant organism (MDRO) gut colonization in patients with Clostridioides difficile infection (CDI). They compared the predictive performance of a regression-based risk score with two other simplified risk stratification approaches. The results showed that a simplified approach using prior healthcare exposure and receipt of prior antibiotics was as effective as individual patient/antibiotic risk modeling in identifying patients at risk for MDRO gut colonization.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Infectious Diseases
Sara Alosaimy, Noor L. Sabagha, Abdalhamid M. Lagnf, Evan J. Zasowski, Taylor Morrisette, Sarah C. J. Jorgensen, Trang D. Trinh, Ryan P. Mynatt, Michael J. Rybak
INFECTIOUS DISEASES AND THERAPY
(2020)
Article
Infectious Diseases
Sarah C. J. Jorgensen, Trang D. Trinh, Evan J. Zasowski, Abdalhamid M. Lagnf, Sahil Bhatia, Sarah M. Melvin, Samuel P. Simon, Joshua R. Rosenberg, Molly E. Steed, Sandra J. Estrada, Taylor Morrisette, Susan L. Davis, Michael J. Rybak
INFECTIOUS DISEASES AND THERAPY
(2020)
Article
Infectious Diseases
Jessica K. Ortwine, Evan J. Zasowski, Jason M. Pogue, Claudia Hanni, Chris Giuliano, Anthony M. Casapao, Ryan Mynatt, Michael J. Rybak
INFECTIOUS DISEASES AND THERAPY
(2019)
Article
Infectious Diseases
Kimberly C. Claeys, Evan J. Zasowski, Trang D. Trinh, Anthony M. Casapao, Jason M. Pogue, Nitin Bhatia, Ryan P. Mynatt, Suprat S. Wilson, Crystal Arthur, Robert Welch, Robert Sherwin, Wasif Hafeez, Donald P. Levine, Keith S. Kaye, George Delgado, Christopher A. Giuliano, Robert Takla, Colleen Rieck, Leonard B. Johnson, Kyle P. Murray, James Gordon, Kate Reyes, Pamela Hartman, Susan L. Davis, Michael J. Rybak
INFECTIOUS DISEASES AND THERAPY
(2019)
Article
Infectious Diseases
Michael J. Rybak, Evan J. Zasowski, Sarah C. J. Jorgensen, Abdalhamid M. Lagnf, Susan L. Davis, Aaron B. Mendelsohn, Vasileios Margaritis
INFECTIOUS DISEASES AND THERAPY
(2019)