期刊
OPEN FORUM INFECTIOUS DISEASES
卷 9, 期 2, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofab651
关键词
MRSA; outcomes; pharmacokinetics; vancomycin
资金
- National Institute of Allergy and Infectious Diseases (NIAID) of the NIH [UM1AI104681]
- NIH [K24-AI093969]
- NIAID [R21AI149026]
In patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased with higher day 2 area under the curve (AUC), even when daily AUCs were within the recommended therapeutic range (400-600). Further data is needed to assess if daily AUCs <400 can be maintained without compromising efficacy.
Among patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400-600). Further data are needed to determine if daily AUCs <400 can be maintained without compromising efficacy.
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