Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate

Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment

(2015) Ganesh Venkatraman et al.   FASEB JOURNAL

Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells

(2014) E. Fuerst et al.   ALLERGY

The role and therapeutic potential of the autotaxin–lysophosphatidate signalling axis in breast cancer

(2014) Katy Teo et al.   BIOCHEMICAL JOURNAL

ENPP2 Contributes to Adipose Tissue Expansion and Insulin Resistance in Diet-Induced Obesity

(2014) S. Nishimura et al.   DIABETES

Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice

(2014) Matthew G. K. Benesch et al.   FASEB JOURNAL

Autotaxin in the crosshairs: Taking aim at cancer and other inflammatory conditions

(2014) Matthew G.K. Benesch et al.   FEBS LETTERS

Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice

(2014) Xiaoyun Tang et al.   JOURNAL OF LIPID RESEARCH

Autotaxin and LPA 1 and LPA 5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

(2014) Sue-Chin Lee et al.   MOLECULAR CANCER RESEARCH

A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation In Vivo and Regulates Urethral Tension

(2014) Hiroshi Saga et al.   PLoS One

Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe

(2013) Mitsuyasu Kawaguchi et al.   ACS Chemical Biology

Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration

(2013) Hideaki Hozumi et al.   LABORATORY INVESTIGATION

A Metabolically-Stabilized Phosphonate Analog of Lysophosphatidic Acid Attenuates Collagen-Induced Arthritis

(2013) Ioanna Nikitopoulou et al.   PLoS One

Role of the autotaxin–lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy

(2012) David N. Brindley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Pharmacological evaluation of a novel cyclic phosphatidic acid derivative 3-S-cyclic phosphatidic acid (3-S-cPA)

(2012) Emi Nozaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin

(2012) Edyta Gendaszewska-Darmach et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Unlike Two Peas in a Pod: Lipid Phosphate Phosphatases and Phosphatidate Phosphatases

(2012) Bernard P. C. Kok et al.   CHEMICAL REVIEWS

Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

(2012) Ioanna Nikitopoulou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cholera toxin inhibits human hepatocarcinoma cell proliferation in vitro via suppressing ATX/LPA axis

(2011) Qi Xia et al.   ACTA PHARMACOLOGICA SINICA

Synthesis of enantiopure 2-carba-cyclic phosphatidic acid and effects of its chirality on biological functions

(2011) Emi Nozaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer

(2011) Gayle Bennett et al.   BMC CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development

(2011) Seiichi Koike et al.   DEVELOPMENTAL DYNAMICS

Kinetic Analysis of Autotaxin Reveals Substrate-specific Catalytic Pathways and a Mechanism for Lysophosphatidic Acid Distribution

(2011) Lauren P. Saunders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

(2011) Rodolphe Dusaulcy et al.   JOURNAL OF LIPID RESEARCH

Insights into autotaxin: how to produce and present a lipid mediator

(2011) Wouter H. Moolenaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway

(2010) Seiichi Koike et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and structure–activity relationships of tyrosine-based inhibitors of autotaxin (ATX)

(2010) James E. East et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of an Activity-Based Probe for Autotaxin

(2010) Silvia Cavalli et al.   CHEMBIOCHEM

Autotaxin--an LPA producing enzyme with diverse functions

(2010) K. Nakanaga et al.   JOURNAL OF BIOCHEMISTRY

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

(2010) H. M. H. G. Albers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acidin vivo

(2009) Jose L. Tomsig et al.   BIOCHEMICAL JOURNAL

Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

(2009) Honglu Zhang et al.   CANCER RESEARCH

Autotaxin/Lysophospholipase D-mediated Lysophosphatidic Acid Signaling Is Required to Form Distinctive Large Lysosomes in the Visceral Endoderm Cells of the Mouse Yolk Sac

(2009) Seiichi Koike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells

(2009) Cristoforo G. Gaetano et al.   MOLECULAR CARCINOGENESIS

Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling

(2008) Catelijne Stortelers et al.   BMC GENOMICS

NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer

(2008) D Murray et al.   BRITISH JOURNAL OF CANCER

Lipid phosphate phosphatases and signaling

(2008) David N. Brindley et al.   JOURNAL OF LIPID RESEARCH

S32826, A Nanomolar Inhibitor of Autotaxin: Discovery, Synthesis and Applications as a Pharmacological Tool

(2008) G. Ferry et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sphingosine-1-Phosphate Mediates Transcriptional Regulation of Key Targets Associated with Survival, Proliferation, and Pluripotency in Human Embryonic Stem Cells

(2008) Katie Avery et al.   STEM CELLS AND DEVELOPMENT