Autotaxin--an LPA producing enzyme with diverse functions

Autotaxin Inhibition: Challenges and Progress Toward Novel Anti-Cancer Agents

(2012) Abby Parrill et al.   Anti-Cancer Agents in Medicinal Chemistry

ATX expression and LPA signalling are vital for the development of the nervous system

(2010) Stella Fotopoulou et al.   DEVELOPMENTAL BIOLOGY

Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-Induced Neuropathic Pain

(2010) L. Ma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Phospholipase C  Activation Drives Increased Production of Autotaxin in Endothelial Cells and Lysophosphatidic Acid-Dependent Regression

(2010) E. Im et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

(2009) Shuying Liu et al.   CANCER CELL

Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells

(2009) Silvia Jansen et al.   CANCER LETTERS

Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

(2009) Honglu Zhang et al.   CANCER RESEARCH

The Absence of LPA2 Attenuates Tumor Formation in an Experimental Model of Colitis-Associated Cancer

(2009) Songbai Lin et al.   GASTROENTEROLOGY

Domain Interplay Mediated by an Essential Disulfide Linkage Is Critical for the Activity and Secretion of the Metastasis-promoting Enzyme Autotaxin

(2009) Silvia Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autotaxin/Lysophospholipase D-mediated Lysophosphatidic Acid Signaling Is Required to Form Distinctive Large Lysosomes in the Visceral Endoderm Cells of the Mouse Yolk Sac

(2009) Seiichi Koike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

(2009) Keisuke Yanagida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of the Lysophosphatidic Acid-Generating Enzyme Autotaxin in Lymphocyte-Endothelial Cell Interactions

(2008) Tae Nakasaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Age-Dependent Loss of Sperm Production in Mice via Impaired Lysophosphatidic Acid Signaling1

(2008) Xiaoqin Ye et al.   BIOLOGY OF REPRODUCTION

Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma

(2008) Akiko Masuda et al.   BRITISH JOURNAL OF HAEMATOLOGY

Role of LPA4/p2y9/GPR23 in Negative Regulation of Cell Motility

(2008) Zendra Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion

(2008) Lauren P. Saunders et al.   MOLECULAR CANCER THERAPEUTICS

Autotaxin, a Synthetic Enzyme of Lysophosphatidic Acid (LPA), Mediates the Induction of Nerve-Injured Neuropathic Pain

(2008) Makoto Inoue et al.   Molecular Pain

G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

(2008) Sandra M Pasternack et al.   NATURE GENETICS

Disruption of P2RY5, an orphan G protein–coupled receptor, underlies autosomal recessive woolly hair

(2008) Yutaka Shimomura et al.   NATURE GENETICS

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY

Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation

(2007) Kazuhiro Nakamura et al.   CLINICA CHIMICA ACTA

Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome

(2007) Kazuhiro Nakamura et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Phosphodiesterase-Iα/autotaxin's MORFO domain regulates oligodendroglial process network formation and focal adhesion organization

(2007) Jameel Dennis et al.   MOLECULAR AND CELLULAR NEUROSCIENCE