Article
Ophthalmology
Shizuka Koh, Ryota Inoue, Naoyuki Maeda, Yoshinori Oie, Vishal Jhanji, Atsuya Miki, Kohji Nishida
Summary: This study found that wearing spherical corneal rigid gas-permeable contact lenses can lead to refractive changes in the posterior corneal surface in keratoconus patients and these changes are correlated with corneal biomechanics. The spherical, regular astigmatism, and asymmetry components were significantly reduced when wearing corneal GPs.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Daniela S. Nosch, Emanuele Kaser, Alice Christen, Julia Schinzel, Roland E. Joos
Summary: This study found no significant difference in corneal sensitivity between contact lens wearers and non-wearers. However, lower levels of corneal sensitivity were observed in male contact lens wearers, warranting further investigation.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Satoko Araki, Shizuka Koh, Daijiro Kabata, Ryota Inoue, Daichi Morii, Naoyuki Maeda, Ayumi Shintani, Vishal Jhanji, Kohji Nishida
Summary: Investigating the long-term effects of rigid gas-permeable contact lens wear on keratoconus, this study found that there was no significant impact on the progression of KC over a 5-6 year period.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Xiao-Di Yang, Yong Lyu
Summary: This study aimed to observe the clinical outcomes of visual rehabilitation using rigid gas-permeable contact lenses (RGPCLs) in children under 12 years old in China who experienced penetrative ocular trauma. The results showed that RGPCLs were a beneficial tool for postoperative visual rehabilitation in children with open ocular trauma, despite the complexity of application and initial discomfort.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2023)
Article
Immunology
Mallika Somayajulu, Sharon A. Mcclellan, Farooq Muhammed, Robert Wright, Linda D. Hazlett
Summary: This study demonstrates the detrimental effects of PM10 exposure on cell viability, oxidative stress, and inflammation in HCET. Furthermore, the study shows that PM10 has an additive effect upon bacterial challenge, exacerbating the negative impacts. However, SKQ1 protects against these effects and restores cell morphology and levels of oxidative stress and pro-inflammatory molecules. These findings provide insight into the mechanisms underlying early perforation and thinning observed in infected corneas of PM10-exposed mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Yu Xue, Jiaqi Zhou, Zhi Chen, Feng Xue, Li Zeng, Xiaomei Qu, Xingtao Zhou
Summary: This study aims to investigate the factors affecting long-term compliance with rigid gas-permeable contact lens wear in patients with keratoconus (KC). The results showed that subjective experiences, such as visual acuity, overall satisfaction, and quality of life, significantly influence long-term compliance with RGPCL wear, while ocular biometrics do not have a significant effect.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Joseph B. Lin, Xiaolei Shen, Charles W. Pfeifer, Fion Shiau, Andrea Santeford, Philip A. Ruzycki, Brian S. Clark, Qin Liu, Andrew J. W. Huang, Rajendra S. Apte
Summary: The study used single-cell RNA sequencing to analyze the transcriptional states of the mouse corneal epithelium in various conditions. They identified transcriptional changes in dry eye disease and proposed a classification system for markers of limbal stem cells. This study provides a framework and atlas for future research on ocular surface stem cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Ophthalmology
Motozumi Itoi, Motohiro Itoi
Summary: Vision correction using corneal rigid gas-permeable contact lenses is the basic and effective method for managing keratoconus. The success rates of different fitting strategies vary depending on the type and severity of keratoconus. Classifying patients into different types according to corneal shape and selecting appropriate prescription techniques is crucial. The piggyback lens system is a good alternative if corneal GPs cannot be used due to mechanical irritation. Instructing patients on proper lens care is important for preventing complications and maintaining visual function.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Ophthalmology
Sabrina Mukhtar, Sarah Atta, Asad Durrani, Chandrashan Perera, Regis Kowalski, Vishal Jhanji
Summary: The degree of microbiological agreement between corneal scrapings and contact lens cultures in cases of contact lens-associated keratitis was investigated. The results showed that although there was disagreement in the microbiological yield, contact lens cultures were useful in managing patients and achieved similar outcomes to corneal scrapings.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qianni Wu, Cheng Yang, Wan Chen, Kexin Chen, Hui-jiuan Chen, Fanmao Liu, Dong Liu, Haotian Lin, Xi Xie, Weirong Chen
Summary: A wireless-powered electrical bandage contact lens (EBCL) is developed to accelerate corneal wound healing and vision recovery through generating a localized external electric field. The electrical stimulation promotes cell migration and alignment, and controls cell division, proliferation, and migration.
Article
Biochemistry & Molecular Biology
Shan Lakmal Edirisinghe, Chamilani Nikapitiya, S. H. S. Dananjaya, Jungho Park, Dukgyu Kim, Dongrack Choi, Mahanama De Zoysa
Summary: This study aimed to develop a corneal epithelial injury model in zebrafish and investigate the effectiveness of PDRN treatment on in vivo corneal epithelial regeneration and wound healing. The results showed that PDRN treatment significantly reduced the wounded area of the zebrafish eye, indicating its potential to accelerate corneal re-epithelialization. Transcriptional analysis results revealed that PDRN treatment induced the expression of several genes related to corneal healing. Overall, this study provides important insights into corneal epithelial healing and the potential application of PDRN treatment in zebrafish.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Mohamed A. Hamed, Amany Farag, Ibrahim S. Zahran, Ahmed Hafez, Mohamed Abdo Rizk, Marwa Abass
Summary: This study demonstrates the efficiency of topically applied pycnogenol in healing alkaline corneal ulcers in diabetic and normal rats. It enhances corneal re-epithelialization and reduces inflammatory reaction, making it a valuable treatment for diabetic keratopathy.
BMC VETERINARY RESEARCH
(2022)
Article
Ophthalmology
Promita Bhattacharjee, Mark Ahearne
Summary: Soft lithography was used to create silk fibroin substrates with spiral topographies, which successfully guided human limbal-derived corneal epithelial cells to form a spiral orientation. The study found that the spiral patterns affected cytoskeletal organization, cell spreading, and nuclei shapes, and had significant impacts on cell proliferation, adhesion, chromatin condensation, and actin filament numbers. The spiral pattern also enhanced the expression of markers associated with limbal stem cells.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Ines De Hoon, Alexandre Barras, Tomasz Swebocki, Bernd Vanmeerhaeghe, Bram Bogaert, Cristina Muntean, Amar Abderrahmani, Rabah Boukherroub, Stefaan De Smedt, Felix Sauvage, Sabine Szunerits
Summary: Topical administration of drugs to the corneal endothelium is challenging in ophthalmology, and diseases at this site can cause corneal blindness. Carbon quantum dots have shown potential for ocular nanomedicine. This study investigated the corneal penetration abilities of differently charged carbon quantum dots and their use as permeation enhancers for drugs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Ophthalmology
Samantha Bradford, Shangbang Luo, Donald Brown, Tibor Juhasz, James Jester
Summary: This review analyzes the research findings on the effects and mechanisms of using UVA CXL in the treatment of corneal ectasia and Keratoconus. While some effects are widely accepted, others are still controversial. Understanding and analyzing these effects and mechanisms are essential for predicting treatment outcomes.
Article
Ophthalmology
Pauline Cho, Hoi Ying Poon, Chia Ching Chen, Lien Tao Yuon
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2020)
Article
Ophthalmology
Qi Tan, Alex L. K. Ng, Bonnie N. K. Choy, George P. M. Cheng, Victor C. P. Woo, Pauline Cho
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2020)
Article
Ophthalmology
Bi Yang, Xueqin Ma, Longqian Liu, Pauline Cho
Summary: The study found that Chinese children wearing orthokeratology lenses had significantly better scores in overall vision, far vision, appearance, satisfaction, activities, and peer perceptions compared to those wearing single vision spectacles. Although some ocular discomfort may occur when wearing ortho-k lenses at night, the benefits outweigh the discomfort, resulting in better vision-related quality of life for Chinese children.
CONTACT LENS & ANTERIOR EYE
(2021)
Review
Ophthalmology
Xingyu Wang, Bi Yang, Longqian Liu, Pauline Cho
Summary: The main motivation for parents to choose ortho-k for their children was the rapid progression of myopia, with most learning about ortho-k through word of mouth. The most common symptom during treatment was itchy or sore eyes, usually only initially. Children's willingness to participate is crucial for successful ortho-k treatment, even though their motivation may differ from that of their parents. Ortho-k is widely accepted as an option for myopia control in children.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Ophthalmology
Stephen J. Vincent, Qi Tan, Alex L. K. Ng, George P. M. Cheng, Victor C. P. Woo, Pauline Cho
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2020)
Article
Ophthalmology
Qi Tan, Alex L. K. Ng, George P. M. Cheng, Victor C. P. Woo, Pauline Cho
Summary: The study found that pupil size measurements using the NIDEK OPD-Scan III were highly repeatable in myopic children, making it suitable for use in this population.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Ophthalmology
Sin Wan Cheung, Maureen Valerie Boost, Pauline Cho
Summary: The study found that using a povidone iodine-based rigid lens disinfecting solution effectively reduced contamination rates of lenses and lens cases and conjunctival colonization. Regardless of the cleaning routine adopted, there were no significant differences observed in conjunctival colonization or contamination of lenses or cases.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Biyue Guo, Pauline Cho, Nathan Efron
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2021)
Article
Ophthalmology
Kin Wan, Hing Tuen Yau, Sin Wan Cheung, Pauline Cho
Summary: This study evaluated thickness changes in different layers of the cornea in myopic children during and after short-term ortho-k lens wear. The results showed significant reductions in CET with higher reduction in eyes wearing ICF lenses, while corneal thickness changes were reversible after discontinuing lens wear.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Ophthalmology
Biyue Guo, Sin Wan Cheung, Randy Kojima, Pauline Cho
Summary: The 1-year results of the VOLTZ Study show that orthokeratology lenses with different back optic zone diameters have a varying effect on myopia control in children. Using lenses with a 5mm BOZD can lead to slower axial elongation, while maintaining similar lens performance and ocular integrity compared to lenses with a 6mm BOZD.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Ophthalmology
Yajing Yang, Sin Wan Cheung, Pauline Cho, Stephen J. Vincent
Summary: The study found that the estimated myopia progression by the BHVI Myopia Calculator was in close agreement with the actual measured values after 1 and 2 years, but caution is advised when interpreting the data as it only fell within the 95% confidence interval for a relatively small percentage of children.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Infectious Diseases
Zhi Chen, Jifang Wang, Jun Jiang, Bi Yang, Pauline Cho
Summary: This study investigated the impact of guidelines on the knowledge, attitude, and prescribing habits of ortho-k practitioners. The findings showed that the implementation of the guidelines significantly improved the overall prescribing habits, but some practitioners still need to improve their behavior.
Article
Ophthalmology
Biyue Guo, Huihuan Wu, Sin Wan Cheung, Pauline Cho
Summary: This study compared the treatment zone measurements obtained using manual and software-based methods in orthokeratology subjects. The results showed significant differences between the two methods, suggesting that they cannot be used interchangeably. The study also found significant differences in treatment zone parameters between slow and fast axial elongation subjects, indicating a potential role of the treatment zone in regulating myopia progression in ortho-k.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2022)
Article
Ophthalmology
Bi Yang, Longqian Liu, Pauline Cho
Summary: This study investigated the compliance of orthokeratology wearers and their parents with care routines in a hospital setting in Chengdu, China. The results showed that parental supervision and instructions from eye care practitioners were important factors in increasing compliance. Regular reinforcement of care procedures, especially for older and male wearers, is crucial.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2022)
Article
Ophthalmology
Biyue Guo, Sin Wan Cheung, Randy Kojima, Pauline Cho
Summary: The purpose of this study was to compare the axial elongation (AE) and treatment zone (TZ) characteristics in children wearing 6 mm or 5 mm orthokeratology lenses over 2 years. The results showed that children wearing 5 mm lenses had a smaller TZ diameter and less AE after 24 months of treatment, with no difference in choroidal thickness changes. In conclusion, using orthokeratology lenses with a smaller back optic zone diameter can slow down axial elongation in children.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)