期刊
ADVANCED SCIENCE
卷 9, 期 31, 页码 -出版社
WILEY
DOI: 10.1002/advs.202202506
关键词
bandage contact lens; cornea wound healing; electrotherapy; wireless powered
资金
- National Key R&D Program of China [2020YFC2008200, 2021YFF1200700]
- Guangdong Basic and Applied Basic Research Foundation [2020A1515110424, 2020A1515010987]
- National Natural Science Foundation of China [81970778, 82101099, 32171399]
- Science and Technology Program of Guangzhou [202102010231]
- Fundamental Research Funds of the State Key Laboratory of Ophthalmology [2022QN07, 2022QN06]
A wireless-powered electrical bandage contact lens (EBCL) is developed to accelerate corneal wound healing and vision recovery through generating a localized external electric field. The electrical stimulation promotes cell migration and alignment, and controls cell division, proliferation, and migration.
Corneal injury can lead to severe vision impairment or even blindness. Although numerous methods are developed to accelerate corneal wound healing, most of them are passive treatments that rarely participate in controlling endogenous cell behaviors or are incompatible with nontransparent bandage. In this work, a wireless-powered electrical bandage contact lens (EBCL) is developed to generate a localized external electric field to accelerate corneal wound healing and vision recovery. The wireless electrical stimulation circuit employed a flower-shaped layout design that can be compactly integrated on bandage contact lens without blocking the vision. The role of the external electric field in promoting corneal wound healing is examined in vitro, where the responses of directional migration and corneal cells alignment to the electric field are observed. The RNA sequencing (RNA-seq) analysis indicates that the electrical stimulation can participate in controlling cell division, proliferation, and migration. Furthermore, the wireless EBCL is demonstrated to accelerate the completed recovery of corneal wounds on rabbits' eyes by electrical stimulation, while the control group exhibits delayed recovery and obvious corneal defects. As a new generation of intelligent device, the wireless and patient-friendly EBCL can provide a promising therapeutic strategy for ocular diseases.
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