Natural Product Synthesis at the Interface of Chemistry and Biology

Chemical Tailoring of Teicoplanin with Site-Selective Reactions

(2013) Tejas P. Pathak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From micrograms to grams: scale-up synthesis of eribulin mesylate

(2013) Melvin J. Yu et al.   NATURAL PRODUCT REPORTS

Natural product synthesis in the age of scalability

(2013) Christian A. Kuttruff et al.   NATURAL PRODUCT REPORTS

14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

(2013) L. Jorgensen et al.   SCIENCE

Process Development of Halaven®: Synthesis of the C14-C35 Fragment via Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization

(2013) Charles Chase et al.   SYNLETT

Commercial Manufacture of Halaven®: Chemoselective Transformations En Route to Structurally Complex Macrocyclic Ketones

(2013) Francis Fang et al.   SYNLETT

Redesign of Glycopeptide Antibiotics: Back to the Future

(2012) Robert C. James et al.   ACS Chemical Biology

Natural Product Synthesis: Changes over Time

(2012) Reinhard W. Hoffmann   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products

(2012) David Y.-K. Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Role of natural product diversity in chemical biology

(2011) Jiyong Hong   CURRENT OPINION IN CHEMICAL BIOLOGY

A Redesigned Vancomycin Engineered for Duald-Ala-d-Ala andd-Ala-d-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

(2011) Jian Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioactivity-Guided Navigation of Chemical Space

(2010) Robin S. Bon et al.   ACCOUNTS OF CHEMICAL RESEARCH

Organocatalytic cascade reactions as a new tool in total synthesis

(2010) Christoph Grondal et al.   Nature Chemistry

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

Cycle-Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product Synthesis

(2009) Bryon Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The art of total synthesis through cascade reactions

(2009) K. C. Nicolaou et al.   CHEMICAL SOCIETY REVIEWS

The economies of synthesis

(2009) Timothy Newhouse et al.   CHEMICAL SOCIETY REVIEWS

Fundamental Relationships between Structure, Reactivity, and Biological Activity for the Duocarmycins and CC-1065

(2009) Karen S. MacMillan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Asymmetric Synthesis of (−)-Incarvillateine Employing an Intramolecular Alkylation via Rh-Catalyzed Olefinic C−H Bond Activation

(2008) Andy S. Tsai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin

(2008) Gordon J. Florence et al.   NATURAL PRODUCT REPORTS

(+)-Discodermolide: total synthesis, construction of novel analogues, and biological evaluation

(2007) Amos B. Smith et al.   TETRAHEDRON