Total Syntheses and Biological Reassessment of Lactimidomycin, Isomigrastatin and Congener Glutarimide Antibiotics

Alkyne Metathesis on the Rise

(2013) Alois Fürstner   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formal Total Synthesis of the Algal Toxin (−)-Polycavernoside A

(2013) Lennart Brewitz et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Total Synthesis of Spirastrellolide A Methyl Ester

(2013) Alexander Arlt et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of Neurymenolide A Based on a Gold-Catalyzed Synthesis of 4-Hydroxy-2-pyrones

(2012) Wojciech Chaładaj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optimized Synthesis, Structural Investigations, Ligand Tuning and Synthetic Evaluation of Silyloxy-Based Alkyne Metathesis Catalysts

(2012) Johannes Heppekausen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

(2012) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An efficient route to the musk odorant (R,Z)-5-muscenone via base-metal-catalysis

(2012) Konrad Lehr et al.   TETRAHEDRON

Diazo Reagents with Small Steric Footprints for Simultaneous Arming/SAR Studies of Alcohol-Containing Natural ProductsviaO–H Insertion

(2011) Supakarn Chamni et al.   ACS Chemical Biology

Second-Generation Total Synthesis of Spirastrellolide F Methyl Ester: The Alkyne Route

(2011) Stefan Benson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Tulearin C

(2011) Konrad Lehr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metathesis in total synthesis

(2011) Alois Fürstner   CHEMICAL COMMUNICATIONS

Molecular Editing and Assessment of the Cytotoxic Properties of Iejimalide and Progeny

(2011) Julien Gagnepain et al.   CHEMISTRY-A EUROPEAN JOURNAL

Gram-Scale Synthesis of Iejimalide B

(2011) Julien Gagnepain et al.   CHEMISTRY-A EUROPEAN JOURNAL

Translating Nature’s Library: The Bryostatins and Function-Oriented Synthesis

(2011) Paul A. Wender et al.   ISRAEL JOURNAL OF CHEMISTRY

From Total Synthesis to Diverted Total Synthesis: Case Studies in the Amphidinolide Series

(2011) Alois Fürstner   ISRAEL JOURNAL OF CHEMISTRY

Mechanism of Actin Filament Bundling by Fascin

(2011) Silvia Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stereoselective Synthesis ofE,Z-Configured 1,3-Dienes by Ring-Closing Metathesis. Application to the Total Synthesis of Lactimidomycin

(2011) Daniel Gallenkamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis-Based and Protecting-Group-Free Total Syntheses of the Marine Oxylipins Hybridalactone and the Ecklonialactones A, B, and C

(2011) Volker Hickmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative Structure-Activity Studies on a Series of Migrastatin Analogs as Inhibitors of Cancer Cell Metastasis

(2011) Ricardo N. Santos et al.   Medicinal Chemistry

Erratum: Migrastatin analogues target fascin to block tumour metastasis

(2011) Lin Chen et al.   NATURE

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin

(2011) N. Lecomte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6

(2011) S. Klinge et al.   SCIENCE

Stereoselective synthesis of analogs of the macrolactone of isomigrastatin

(2011) Luiz C. Dias et al.   TETRAHEDRON LETTERS

On the Reach of Chemical Synthesis: Creation of a Mini-Pipeline from an Academic Laboratory

(2010) Rebecca M. Wilson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis

(2010) Alex M. Szpilman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactones

(2010) Anniefer N. Magpusao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multifaceted Modes of Action for the Glutarimide-Containing Polyketides Revealed

(2010) Scott R. Rajski et al.   CHEMBIOCHEM

Synthesis of the Macrolactone of Migrastatin and Analogues with Potent Cell-Migration Inhibitory Activity

(2010) Luiz C. Dias et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis:In vivoand Mechanistic Studies on the Migrastatin Core Ether Analog

(2010) Thordur Oskarsson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Concise Total Synthesis of the Potent Translation and Cell Migration Inhibitor Lactimidomycin

(2010) Kevin Micoine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical New Silyloxy-Based Alkyne Metathesis Catalysts with Optimized Activity and Selectivity Profiles

(2010) Johannes Heppekausen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protecting-Group-Free and Catalysis-Based Total Synthesis of the Ecklonialactones

(2010) Volker Hickmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Migrastatin analogues target fascin to block tumour metastasis

(2010) Lin Chen et al.   NATURE

Garbled messages and corrupted translations

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

(2010) Pavel Nagorny et al.   TETRAHEDRON LETTERS

Synthesis of congeners of migrastatin and dorrigocin A from d-xylose

(2010) Ying Zhou et al.   TETRAHEDRON LETTERS

Enantioselective formal total synthesis of the Dendrobatidae frog toxin, (+)-pumiliotoxin B, via O-directed alkyne free radical hydrostannation

(2010) Soraya Manaviazar et al.   TETRAHEDRON LETTERS

Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009

(2009) Alfonso Quintás-Cardama et al.   CANCER

Preparation, Modification, and Evaluation of Cruentaren A and Analogues

(2009) Martin Bindl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Molecular Editing and Biological Evaluation of Amphidinolide X and Y

(2009) Alois Fürstner et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis and Biological Evaluation of the Cytotoxic Resin Glycosides Ipomoeassin A-F and Analogues

(2009) Takashi Nagano et al.   CHEMISTRY-A EUROPEAN JOURNAL

Lactimidomycin, Iso-migrastatin and Related Glutarimide-Containing 12-Membered Macrolides Are Extremely Potent Inhibitors of Cell Migration

(2009) Jianhua Ju et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Altering Chemosensitivity by Modulating Translation Elongation

(2009) Francis Robert et al.   PLoS One

Engineered production of iso-migrastatin in heterologous Streptomyces hosts

(2008) Zhiyang Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency

(2008) Jianhua Ju et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin fromD-Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener Is a Potent Inhibitor of Gastric Cancer Cell Migration

(2008) Guillaume Anquetin et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Highly β-(E)-Selective Hydrosilylation of Terminal and Internal Alkynes Catalyzed by a (IPr)Pt(diene) Complex

(2008) Guillaume Berthon-Gelloz et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Syntheses of (+)-Tedanolide and (+)-13-Deoxytedanolide

(2008) Joshua R. Dunetz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Stereoselective Synthesis of the Macrolide Core of Migrastatin

(2008) Parthasarathi Das et al.   SYNTHESIS-STUTTGART

(BDP)CuH:  A “Hot” Stryker's Reagent for Use in Achiral Conjugate Reductions

(2007) Benjamin A. Baker et al.   ORGANIC LETTERS