期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 9, 页码 3224-3228出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja9101503
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资金
- NIH [CA103823, CA126518, CA129243]
- Alan and Sandra Gerry Metastasis Research Initiative
- Cancer Research Institute Gar Reichman Award
- Howard Hughes Medical Institute
- National Institutes of Health [CA 125934-02]
A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.
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