Membrane Disruption and Enhanced Inhibition of Cell-Wall Biosynthesis: A Synergistic Approach to Tackle Vancomycin-Resistant Bacteria

Amphiphilic Tobramycins with Immunomodulatory Properties

(2015) Goutam Guchhait et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo antibacterial activity and pharmacological properties of the membrane-active glycopeptide antibiotic YV11455

(2015) Venkateswarlu Yarlagadda et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

In vivo efficacy and pharmacological properties of a novel glycopeptide (YV4465) against vancomycin-intermediate Staphylococcus aureus

(2015) Venkateswarlu Yarlagadda et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Structure Diversification of Vancomycin through Peptide-Catalyzed, Site-Selective Lipidation: A Catalysis-Based Approach To Combat Glycopeptide-Resistant Pathogens

(2015) Sabesan Yoganathan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Tackling vancomycin-resistant bacteria with ‘lipophilic–vancomycin–carbohydrate conjugates’

(2014) Venkateswarlu Yarlagadda et al.   JOURNAL OF ANTIBIOTICS

Glycopeptide antibiotics: Back to the future

(2014) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Membrane Active Phenylalanine Conjugated Lipophilic Norspermidine Derivatives with Selective Antibacterial Activity

(2014) Mohini M. Konai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane Active Vancomycin Analogues: A Strategy to Combat Bacterial Resistance

(2014) Venkateswarlu Yarlagadda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecular Antibacterial Peptoid Mimics: The Simpler the Better!

(2014) Chandradhish Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli

(2014) Tengfei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

(2014) Peter I. O’Daniel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small cationic antimicrobial peptides delocalize peripheral membrane proteins

(2014) M. Wenzel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

(2013) Kieron M. G. O'Connell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

(2013) Divakara S. S. M. Uppu et al.   CHEMICAL COMMUNICATIONS

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Identifying producers of antibacterial compounds by screening for antibiotic resistance

(2013) Maulik N Thaker et al.   NATURE BIOTECHNOLOGY

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Increased Cell Wall Teichoic Acid Production and D-alanylation Are Common Phenotypes among Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) Clinical Isolates

(2013) Ute Bertsche et al.   PLoS One

Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria

(2013) J. R. Morones-Ramirez et al.   Science Translational Medicine

Redesign of Glycopeptide Antibiotics: Back to the Future

(2012) Robert C. James et al.   ACS Chemical Biology

Dendrimer-Based Multivalent Vancomycin Nanoplatform for Targeting the Drug-Resistant Bacterial Surface

(2012) Seok Ki Choi et al.   ACS Nano

The emerging problem of linezolid-resistant Staphylococcus

(2012) B. Gu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Design and synthesis of unprecedented cyclic γ-AApeptides for antimicrobial development

(2012) Haifan Wu et al.   Chemical Science

Recent advances in the synthesis of new glycopeptide antibiotics

(2011) Polly-Anna Ashford et al.   CHEMICAL SOCIETY REVIEWS

A Redesigned Vancomycin Engineered for Duald-Ala-d-Ala andd-Ala-d-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

(2011) Jian Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of [Ψ[C(═S)NH]Tpg4]Vancomycin Aglycon, [Ψ[C(═NH)NH]Tpg4]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding

(2011) Jian Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tackling antibiotic resistance

(2011) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

New Lipoglycopeptides

(2010) George G. Zhanel et al.   DRUGS

Discovery of a Novel Series of Semisynthetic Vancomycin Derivatives Effective against Vancomycin-Resistant Bacteria

(2010) Yuki Nakama et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers: Effect on membrane permeability and nanoscale lipid membrane organization

(2009) Oscar Domenech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Time-kill kinetics of oritavancin and comparator agents against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium

(2009) G. A. McKay et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

(2009) S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis

(2008) Gemma L. Thomas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Bacteria Fight Back

(2008) G. Taubes   SCIENCE

The bacterial envelope as a target for novel anti-MRSA antibiotics

(2008) Françoise Van Bambeke et al.   TRENDS IN PHARMACOLOGICAL SCIENCES