A Synthetic Lipid A Mimetic Modulates Human TLR4 Activity

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa

(2014) C. Walsh et al.   JOURNAL OF IMMUNOLOGY

Epidemiology and risk factors of sepsis after multiple trauma: An analysis of 29,829 patients from the Trauma Registry of the German Society for Trauma Surgery*

(2011) Arasch Wafaisade et al.   CRITICAL CARE MEDICINE

Current insights in sepsis

(2011) W. Joost Wiersinga   Current Opinion in Critical Care

Targeting of Toll-like receptors: a decade of progress in combating infectious diseases

(2011) Mona Hedayat et al.   LANCET INFECTIOUS DISEASES

The cationic amphiphile 3,4-bis(tetradecyloxy)benzylamine inhibits LPS signaling by competing with endotoxin for CD14 binding

(2010) Matteo Piazza et al.   BIOCHEMICAL PHARMACOLOGY

Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets

(2010) Matteo Piazza et al.   Innate Immunity

MD-2 Residues Tyrosine 42, Arginine 69, Aspartic Acid 122, and Leucine 125 Provide Species Specificity for Lipid IVA

(2010) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of a Specific Interaction between New Synthetic Antisepsis Agents and CD14

(2009) Matteo Piazza et al.   BIOCHEMISTRY

Chemical Synthesis and Proinflammatory Responses of Monophosphoryl Lipid A Adjuvant Candidates

(2009) Kaustabh K. Maiti et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Glycolipids and Benzylammonium Lipids as Novel Antisepsis Agents: Synthesis and Biological Characterization

(2009) Matteo Piazza et al.   JOURNAL OF MEDICINAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Synthetic TLR4-active Glycolipids as Vaccine Adjuvants and Stand-alone Immunotherapeutics

(2008) David Johnson   CURRENT TOPICS IN MEDICINAL CHEMISTRY