Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme–CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

(2018) Liberty François-Moutal et al.   PAIN

Na V 1.7 as a Pharmacogenomic Target for Pain: Moving Toward Precision Medicine

(2018) Yang Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Blocking CRMP2 SUMOylation reverses neuropathic pain

(2017) A Moutal et al.   MOLECULAR PSYCHIATRY

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase

(2015) Laurent Cappadocia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel method for the study of molecular interaction by using microscale thermophoresis

(2015) Yexuan Mao et al.   TALANTA

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase

(2015) Laurent Cappadocia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

(2014) Sarah M. Wilson et al.   Frontiers in Cellular Neuroscience

Template-based structure modeling of protein–protein interactions

(2013) Andras Szilagyi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CRMP2 Protein SUMOylation Modulates NaV1.7 Channel Trafficking

(2013) Erik T. Dustrude et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Inhibition of Transmitter Release and Attenuation of Anti-retroviral-associated and Tibial Nerve Injury-related Painful Peripheral Neuropathy by Novel Synthetic Ca2+Channel Peptides

(2012) Sarah M. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear magnetic resonance analysis of protein-DNA interactions

(2011) S. Campagne et al.   Journal of the Royal Society Interface

DNA Repair and Global Sumoylation Are Regulated by Distinct Ubc9 Noncovalent Complexes

(2011) J. Prudden et al.   MOLECULAR AND CELLULAR BIOLOGY

Thioredoxin Mediates Oxidation-Dependent Phosphorylation of CRMP2 and Growth Cone Collapse

(2011) A. Morinaka et al.   Science Signaling

Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation

(2010) Marlene Grünwald et al.   EMBO JOURNAL

Mechanism of E1-E2 Interaction for the Inhibition of Ubl Adenylation

(2010) Jianghai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mechanistic View of the Role of E3 in Sumoylation

(2010) Melda Tozluoğlu et al.   PLoS Computational Biology

Demonstration of protein-protein interaction specificity by NMR chemical shift mapping

(2009) Ponni Rajagopal et al.   PROTEIN SCIENCE

Crystal and solution structure, stability and post-translational modifications of collapsin response mediator protein 2

(2008) Viivi Majava et al.   FEBS Journal