期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 8, 期 61, 页码 1065-1078出版社
ROYAL SOC
DOI: 10.1098/rsif.2010.0543
关键词
structural biology; protein-DNA complex; nuclear magnetic resonance
Recent methodological and instrumental advances in solution-state nuclear magnetic resonance have opened up the way to investigating challenging problems in structural biology such as large macromolecular complexes. This review focuses on the experimental strategies currently employed to solve structures of protein-DNA complexes and to analyse their dynamics. It highlights how these approaches can help in understanding detailed molecular mechanisms of target recognition.
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