Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity

Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins

(2013) Oliver Stehling et al.   Cell Metabolism

Viperin Is Induced following Dengue Virus Type-2 (DENV-2) Infection and Has Anti-viral Actions Requiring the C-terminal End of Viperin

(2013) Karla J. Helbig et al.   PLoS Neglected Tropical Diseases

Viperin restricts chikungunya virus replication and pathology

(2012) Terk-Shin Teng et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection

(2012) K. S. Tan et al.   JOURNAL OF GENERAL VIROLOGY

Replication of Respiratory Syncytial Virus Is Inhibited by the Host Defense Molecule Viperin

(2012) Glen McGillivary et al.   Journal of Innate Immunity

Viperin, MTAP44, and Protein Kinase R Contribute to the Interferon-Induced Inhibition of Bunyamwera Orthobunyavirus Replication

(2012) C. Carlton-Smith et al.   JOURNAL OF VIROLOGY

Viral immune modulators perturb the human molecular network by common and unique strategies

(2012) Andreas Pichlmair et al.   NATURE

The Presence of the Iron-Sulfur Motif Is Important for the Conformational Stability of the Antiviral Protein, Viperin

(2012) Shubhasis Haldar et al.   PLoS One

MMS19 Assembles Iron-Sulfur Proteins Required for DNA Metabolism and Genomic Integrity

(2012) O. Stehling et al.   SCIENCE

Viperin: A Multifunctional, Interferon-Inducible Protein that Regulates Virus Replication

(2011) Jun-Young Seo et al.   Cell Host & Microbe

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A

(2011) Karla J. Helbig et al.   HEPATOLOGY

Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells

(2011) Tatsuya Saitoh et al.   IMMUNITY

Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33

(2011) S. Wang et al.   JOURNAL OF GENERAL VIROLOGY

The Interferon-Inducible Gene viperin Restricts West Nile Virus Pathogenesis

(2011) K. J. Szretter et al.   JOURNAL OF VIROLOGY

Viperin, a key player in the antiviral response

(2011) Sandy Mattijssen et al.   MICROBES AND INFECTION

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

(2011) Andreas Pichlmair et al.   NATURE IMMUNOLOGY

Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

(2011) J.-Y. Seo et al.   SCIENCE

The antiviral protein viperin is a radical SAM enzyme

(2010) Kaitlin S. Duschene et al.   FEBS LETTERS

The Interferon Inducible Gene: Viperin

(2010) Katherine A. Fitzgerald   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Critical role of lipid rafts in virus entry and activation of phosphoinositide 3′ kinase/Akt signaling during early stages of Japanese encephalitis virus infection in neural stem/progenitor cells

(2010) Sulagna Das et al.   JOURNAL OF NEUROCHEMISTRY

Tick-Borne Encephalitis Virus Delays Interferon Induction and Hides Its Double-Stranded RNA in Intracellular Membrane Vesicles

(2010) A. K. Overby et al.   JOURNAL OF VIROLOGY

Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections

(2010) D. Jiang et al.   JOURNAL OF VIROLOGY

Structural characterization reveals that viperin is a radical S-adenosyl-l-methionine (SAM) enzyme

(2009) Goyal Shaveta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression of Th2-skewed pathology mediators in monocyte-derived type 2 of dendritic cells (DC2)

(2009) Mitsumi Hata et al.   IMMUNOLOGY LETTERS

The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic  -helix

(2009) E. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF- B and AP-1

(2008) L.-Q. Qiu et al.   BLOOD

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The N-terminal Amphipathic α-Helix of Viperin Mediates Localization to the Cytosolic Face of the Endoplasmic Reticulum and Inhibits Protein Secretion

(2008) Ella R. Hinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T7 RNA polymerase-dependent and -independent systems for cDNA-based rescue of Rift Valley fever virus

(2008) M. Habjan et al.   JOURNAL OF GENERAL VIROLOGY

The Cellular Antiviral Protein Viperin Is Attenuated by Proteasome-Mediated Protein Degradation in Japanese Encephalitis Virus-Infected Cells

(2008) Y.-L. Chan et al.   JOURNAL OF VIROLOGY

Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection

(2008) H. Aizaki et al.   JOURNAL OF VIROLOGY

West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of  v 3 Integrin

(2008) G. R. Medigeshi et al.   JOURNAL OF VIROLOGY

Tick-borne encephalitis

(2008) Lars Lindquist et al.   LANCET

Human Nbp35 Is Essential for both Cytosolic Iron-Sulfur Protein Assembly and Iron Homeostasis

(2008) O. Stehling et al.   MOLECULAR AND CELLULAR BIOLOGY