Article
Clinical Neurology
David C. Hondius, Frank Koopmans, Conny Leistner, Debora Pita-Illobre, Regina M. Peferoen-Baert, Fenna Marbus, Iryna Paliukhovich, Ka Wan Li, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans, August B. Smit
Summary: This study provides a comprehensive assessment of protein abundances in neurons with granulovacuolar degeneration (GVD) and those bearing neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) patients. The research revealed significant changes in protein composition in GVD and tangle-bearing neurons, with proteins related to protein folding, proteasomal function, endolysosomal pathway, and microtubule function being affected in GVD neurons. The study suggests that GVD is part of a pre-NFT stage in AD pathogenesis and may disrupt proteostasis and cellular homeostasis.
ACTA NEUROPATHOLOGICA
(2021)
Article
Neurosciences
Dietmar Rudolf Thal, Sandra O. Tome
Summary: p-tau pathology plays a crucial role in Alzheimer's disease, serving as a prerequisite for AD development. Other proteins such as A beta and TDP-43 may accelerate the accumulation and propagation of p-tau pathology, ultimately leading to the full-blown picture of AD.
BRAIN RESEARCH BULLETIN
(2022)
Article
Medicine, Research & Experimental
Linchi Jiao, Zhihua Yu, Xin Zhong, Weifan Yao, Lijuan Xing, Guowei Ma, Jiajia Shen, Yuqiang Wu, Ke Du, Junxiu Liu, Junhui Tong, Jia Fu, Minjie Wei, Mingyan Liu
Summary: This study demonstrated that Cordycepin (CCS) improved learning and memory impairment in AD mice by promoting MG-M2 activation, inhibiting neuronal apoptosis, and promoting synaptic remodeling. This study provides new insights for the development of novel strategies for AD therapy and offers new targets for anti-AD drug development.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Xu Hou, Jens O. Watzlawik, Casey Cook, Chia-Chen Liu, Silvia S. Kang, Wen-Lang Lin, Michael DeTure, Michael G. Heckman, Nancy N. Diehl, Fadi S. Hanna Al-Shaikh, Ronald L. Walton, Owen A. Ross, Heather L. Melrose, Nilufer Ertekin-Taner, Guojun Bu, Leonard Petrucelli, John D. Fryer, Melissa E. Murray, Dennis W. Dickson, Fabienne C. Fiesel, Wolfdieter Springer
Summary: The study reveals alterations in mitophagy in AD that are associated with early tau pathology, suggesting that distinct mitochondrial, autophagic, and/or lysosomal failures may contribute to the selective vulnerability in the disease.
ALZHEIMERS & DEMENTIA
(2021)
Review
Biochemistry & Molecular Biology
Noora Alhajri, Mohammad Rustom, Adedayo Adegbile, Weshah Ahmed, Salsabeel Kilidar, Nariman Afify
Summary: Cardiovascular diseases are the leading cause of death globally. Network medicine, an emerging field, aims to understand the complex mechanisms of disease by studying the disrupted relationships between biological components. It has potential implications for future research and approaches in cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Danze Chen, Shijia Hao, Jianzhen Xu
Summary: The study explores the relationship between circRNAs in Alzheimer's disease and cancer, finding an inverse correlation in certain cancer types. CircRNAs associated with AD diagnosis and severity were negatively correlated in more cancer types, suggesting a common pathogenesis involving inflammation signaling. The study identified hub nodes in the circRNA-miRNA-target network and highlighted the relevance of inflammation signaling for potential therapeutic targeting of circRNAs in Alzheimer's disease and cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Marta Jorge-Oliva, Jasper F. M. Smits, Vera I. Wiersma, Jeroen J. M. Hoozemans, Wiep Scheper
Summary: This study investigates the connection between pathological protein accumulations and GVBs in neurons. The researchers found that GVBs are closely associated with cytosolic pathological tau in tauopathy, but can also be present in the absence of cytosolic tau accumulation in Parkinson's disease. GVBs in both tauopathy and alpha-synuclein pathology show similar immunoreactivity for phosphorylated tau epitopes, suggesting a common mechanism. The emergence of GVBs is identified as a generalized response to cytosolic protein pathology.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Xinyan Wu, Xiaomei Zheng, Huaqiao Tang, Ling Zhao, Changliang He, Yuanfeng Zou, Xu Song, Lixia Li, Zhongqiong Yin, Gang Ye
Summary: This study identified that curcumin can treat Alzheimer's disease by regulating multiple targets and pathways through network pharmacology.
Article
Clinical Neurology
Meng Zhang, Andrea B. Ganz, Susan Rohde, Linda Lorenz, Annemieke J. M. Rozemuller, Kimberley van Vliet, Marieke Graat, Sietske A. M. Sikkes, Marcel J. T. Reinders, Philip Scheltens, Marc Hulsman, Jeroen J. M. Hoozemans, Henne Holstege
Summary: Among 85 centenarians, levels of neuropathological substrates varied, and only Braak-NFT stage and LATE pathology significantly associated with cognitive performance. The clock-drawing test was particularly sensitive to levels of multiple neuropathologies.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Neus Barranco, Virginia Pla, Daniel Alcolea, Irene Sanchez-Dominguez, Reiner Fischer-Colbrie, Isidro Ferrer, Alberto Lleo, Fernando Aguado
Summary: The study found significant alterations in neuronal-specific prohormone convertases in cerebrospinal fluid and cortical tissues of Alzheimer's disease patients, suggesting that neuronal DCV cargos may be candidate biomarkers for synaptic dysfunction and neurodegeneration in AD.
TRANSLATIONAL NEURODEGENERATION
(2021)
Review
Biochemical Research Methods
Ettore Mosca, Matteo Bersanelli, Tommaso Matteuzzi, Noemi Di Nanni, Gastone Castellani, Luciano Milanesi, Daniel Remondini
Summary: The interactome, a complex network of macromolecular interactions within cells, lacks a clear consensus on its exact structure. Different experimental techniques and functional analyses have generated genome-scale maps of the human interactome. It remains uncertain to what extent these interactomes yield similar results when used in network biology approaches. Parameters such as topology, protein complexes, molecular pathways, pathway cross-talk, and disease gene prediction are compared to provide guidelines for selecting interactomes in future applications.
BRIEFINGS IN BIOINFORMATICS
(2021)
Editorial Material
Multidisciplinary Sciences
Orsolya Barabas, Phoebe A. A. Rice
Summary: CRISPR-Cas is a bacterial defense system that can either protect host cells by attacking invading DNA or assist in the safe insertion of DNA into the genome. The structures of this specific type of CRISPR-Cas system have been successfully visualized.
Editorial Material
Multidisciplinary Sciences
Felicia Kuperwaser, Itai Yanai
Summary: A comprehensive cell atlas of gene expression and regulation in human embryos has provided a unique opportunity for innovative investigation of development through multi-organ and multi-modal analysis.
Editorial Material
Multidisciplinary Sciences
Fahad Rashid, James Berger
Summary: High-resolution structures of bacterial Rho protein in complex with an RNA polymerase enzyme and partner proteins confirm the long-held model of Rho's role in gene transcription termination.
Review
Biochemistry & Molecular Biology
Emily Samuela Turilli, Marta Lualdi, Mauro Fasano
Summary: The outbreak of the SARS-CoV-2 pandemic has driven the scientific community to seek rapid solutions to cope with the health emergency. The complexity of COVID-19 in terms of clinical outcomes, severity, and therapy response suggests the use of multifactorial strategies and systems biology approaches. Proteomics, interactomics, and artificial intelligence tools have been used to understand the pathobiology of COVID-19, identify drug targets, and repurpose drugs.
Article
Biochemistry & Molecular Biology
Haruka Endo, Shiho Tanaka, Satomi Adegawa, Fumika Ichino, Hiroko Tabunoki, Shingo Kikuta, Ryoichi Sato
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Takahiro Otsuki, Daisuke Uka, Hiromu Ito, Genki Ichinose, Momoka Nii, Satoru Morita, Takuma Sakamoto, Maaya Nishiko, Hiroko Tabunoki, Kazuya Kobayashi, Kenji Matsuura, Kikuo Iwabuchi, Jin Yoshimura
SCIENTIFIC REPORTS
(2019)
Article
Developmental Biology
Hitomi Ohno, Takuma Sakamoto, Rena Okochi, Maaya Nishiko, Shunya Sasaki, Hidemasa Bono, Hiroko Tabunoki, Kikkuo Iwabuchi
DEVELOPMENTAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Yosui Nojima, Hidemasa Bono, Takeshi Yokoyama, Kikuo Iwabuchi, Ryoichi Sato, Katsuhiko Arai, Hiroko Tabunoki
SCIENTIFIC REPORTS
(2019)
Article
Biotechnology & Applied Microbiology
Takuma Sakamoto, Maaya Nishiko, Hidemasa Bono, Takeru Nakazato, Jin Yoshimura, Hiroko Tabunoki, Kikuo Iwabuchi
Article
Multidisciplinary Sciences
Wakana Nakane, Hisashi Nakamura, Takeru Nakazato, Natsuki Kaminaga, Miho Nakano, Takuma Sakamoto, Maaya Nishiko, Hidemasa Bono, Isao Ogiwara, Yoshikazu Kitano, Kikuo Iwabuchi, Kaoru Kinoshita, Richard J. Simpson, Hiroko Tabunoki
SCIENTIFIC REPORTS
(2020)
Article
Entomology
Yumi Takano, Takuma Sakamoto, Hiroko Tabunoki, Jin Yoshimura, Kikuo Iwabuchi
Summary: Temperature plays a critical role in influencing animals, especially acclimation and challenge temperatures. Research shows that haemocyte concentration is affected by temperature, and increasing challenge temperature enhances phagocytic activity.
PHYSIOLOGICAL ENTOMOLOGY
(2021)
Correction
Multidisciplinary Sciences
Wakana Nakane, Hisashi Nakamura, Takeru Nakazato, Natsuki Kaminaga, Miho Nakano, Takuma Sakamoto, Maaya Nishiko, Hidemasa Bono, Isao Ogiwara, Yoshikazu Kitano, Kikuo Iwabuchi, Kaoru Kinoshita, Richard J. Simpson, Hiroko Tabunoki
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Shunya Sasaki, Maaya Nishiko, Takuma Sakamoto, Michael R. Kanost, Hiroko Tabunoki
Summary: The DJ-1 gene is highly conserved in insects, such as Tribolium castaneum, and plays an important role in antioxidative stress mechanisms. TcDJ-1 exhibits higher mRNA expression levels during early pupal and adult stages and knockout leads to increased sensitivity to oxidative stress.
Article
Entomology
Hidemasa Bono, Takuma Sakamoto, Takeya Kasukawa, Hiroko Tabunoki
Summary: This paper presents a workflow-based method for annotating gene functions in insects using transcribed sequence information and reference genome databases. The functional annotation information obtained greatly expands the possibilities of entomological research using genome editing. The improved workflow allows for more comprehensive utilization of transcriptome data and is applicable to other insects.
Article
Biochemistry & Molecular Biology
Jacob J. Weber, Lisa M. Brummett, Michelle E. Coca, Hiroko Tabunoki, Michael R. Kanost, Emily J. Ragan, Yoonseong Park, Maureen J. Gorman
Summary: The study found that transferrin-1 (Tsf1) plays a role in iron distribution and antimicrobial activity in Drosophila melanogaster, but has limited involvement in iron transport and protection against oxidative stress. Moreover, Tsf1 may function in providing iron for eggs and defending against infection.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Biology
Takuma Sakamoto, Shunya Sasaki, Nobuki Yamaguchi, Miho Nakano, Hiroki Sato, Kikuo Iwabuchi, Hiroko Tabunoki, Richard J. Simpson, Hidemasa Bono
Summary: The study compared the nutritional metabolism system among flight-winged, flightless-winged, and flightless-wingless stick insect groups. Results indicated that carbohydrate metabolic processes may be related to the evolutionary process through which stick insects gain the ability of flight, as suggested by the differences in gene expression observed in the midgut transcriptome of different stick insect groups.
BMC RESEARCH NOTES
(2021)
Article
Multidisciplinary Sciences
Yuta Kobayashi, Yosui Nojima, Takuma Sakamoto, Kikuo Iwabuchi, Takeru Nakazato, Hidemasa Bono, Atsushi Toyoda, Asao Fujiyama, Michael R. Kanost, Hiroko Tabunoki
SCIENTIFIC REPORTS
(2019)
Article
Biology
Hiroko Tabunoki, Neal T. Dittmer, Maureen J. Gorman, Michael R. Kanost
BMC RESEARCH NOTES
(2019)
Article
Pharmacology & Pharmacy
Fumika Ichino, Hidemasa Bono, Takeru Nakazato, Atsushi Toyoda, Asao Fujiyama, Kikuo Iwabuchi, Ryoichi Sato, Hiroko Tabunoki
DRUG DISCOVERIES AND THERAPEUTICS
(2018)