Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes

An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis

(2013) Chang Y. Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intracellular Encoding of Spatiotemporal Guidance Cues in a Self-Organizing Signaling System for Chemotaxis in Dictyostelium Cells

(2013) Tatsuo Shibata et al.   BIOPHYSICAL JOURNAL

GxcC connects Rap and Rac signaling during Dictyostelium development

(2013) Katarzyna Plak et al.   BMC CELL BIOLOGY

Intracellular photoactivation of caged cGMP induces myosin II and actin responses in motile cells

(2013) Eva K. B. Pfannes et al.   Integrative Biology

The PSGL-1–L-selectin signaling complex regulates neutrophil adhesion under flow

(2013) Anika Stadtmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans

(2013) H. Unnewehr et al.   JOURNAL OF IMMUNOLOGY

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration

(2013) Chuan-Hsiang Huang et al.   NATURE CELL BIOLOGY

Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils

(2013) S. N. Dandekar et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils

(2013) Asako Itakura et al.   PLoS One

Filamin-A Regulates Neutrophil Uropod Retraction through RhoA during Chemotaxis

(2013) Chunxiang Sun et al.   PLoS One

Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations

(2013) C. Westendorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase geometries of two-dimensional excitable waves govern self-organized morphodynamics of amoeboid cells

(2013) D. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of Motility, Directional Sensing, and Polarity Modules Recreates the Behaviors of Chemotaxing Cells

(2013) Changji Shi et al.   PLoS Computational Biology

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules

(2012) S. Kumar et al.   BLOOD

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Network Crosstalk Dynamically Changes during Neutrophil Polarization

(2012) Chin-Jen Ku et al.   CELL

Pseudopod Growth and Evolution during Cell Movement Is Controlled through SCAR/WAVE Dephosphorylation

(2012) Seiji Ura et al.   CURRENT BIOLOGY

A Gβγ Effector, ElmoE, Transduces GPCR Signaling to the Actin Network during Chemotaxis

(2012) Jianshe Yan et al.   DEVELOPMENTAL CELL

GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

(2012) Sabine Suire et al.   EMBO JOURNAL

Fellow travellers: emergent properties of collective cell migration

(2012) Pernille Rørth   EMBO REPORTS

Phosphorylation of Actin-related Protein 2 (Arp2) Is Required for Normal Development and cAMP Chemotaxis inDictyostelium

(2012) Chang-Hoon Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Binding and Regulation of RhoA Protein by Cyclic GMP-dependent Protein Kinase Iα

(2012) Mikio Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCAR knockouts inDictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods

(2012) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses

(2012) Kamalakkannan Srinivasan et al.   JOURNAL OF CELL SCIENCE

The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish

(2012) P.-y. Lam et al.   JOURNAL OF CELL SCIENCE

A dual role for Rac1 GTPases in the regulation of cell motility

(2012) V. Filic et al.   JOURNAL OF CELL SCIENCE

Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion

(2012) Subhanjan Mondal et al.   MOLECULAR BIOLOGY OF THE CELL

Radil controls neutrophil adhesion and motility through β2-integrin activation

(2012) Lunhua Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility

(2012) Verena Kölsch et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of actin cytoskeleton by Rap1 binding to RacGEF1

(2012) Hyemin Mun et al.   MOLECULES AND CELLS

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases

(2012) Xiaowen Liu et al.   NATURE IMMUNOLOGY

Innate Non-Specific Cell Substratum Adhesion

(2012) William F. Loomis et al.   PLoS One

Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion

(2012) Y. Artemenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin I Links PIP3 Signaling to Remodeling of the Actin Cytoskeleton in Chemotaxis

(2012) C.-L. Chen et al.   Science Signaling

Abl Family Kinases Modulate T Cell-Mediated Inflammation and Chemokine-Induced Migration Through the Adaptor HEF1 and the GTPase Rap1

(2012) J. J. Gu et al.   Science Signaling

Incoherent Feedforward Control Governs Adaptation of Activated Ras in a Eukaryotic Chemotaxis Pathway

(2012) K. Takeda et al.   Science Signaling

CXCR7 impact on CXCL12 biology and disease

(2012) Lorena Sánchez-Martín et al.   TRENDS IN MOLECULAR MEDICINE

CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules

(2011) S. Kliche et al.   BLOOD

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions

(2011) C. Costa et al.   BLOOD

The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils

(2011) L. Gambardella et al.   BLOOD

Directed cell invasion and migration during metastasis

(2011) Jose Javier Bravo-Cordero et al.   CURRENT OPINION IN CELL BIOLOGY

A PLCβ/PI3Kγ-GSK3 Signaling Pathway Regulates Cofilin Phosphatase Slingshot2 and Neutrophil Polarization and Chemotaxis

(2011) Wenwen Tang et al.   DEVELOPMENTAL CELL

Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

(2011) Arjan Kortholt et al.   EMBO REPORTS

Nhe1 Is Essential for Potassium but Not Calcium Facilitation of Cell Motility and the Monovalent Cation Requirement for Chemotactic Orientation in Dictyostelium discoideum

(2011) Daniel F. Lusche et al.   EUKARYOTIC CELL

Interstitial locomotion of leukocytes

(2011) Michael Sixt   IMMUNOLOGY LETTERS

CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration

(2011) Fabien M. Décaillot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine CXCL12 Uses CXCR4 and a Signaling Core Formed by Bifunctional Akt, Extracellular Signal-regulated Kinase (ERK)1/2, and Mammalian Target of Rapamycin Complex 1 (mTORC1) Proteins to Control Chemotaxis and Survival Simultaneously in Mature Dendritic Cells

(2011) Cristina Delgado-Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge

(2011) Y. He et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion

(2011) N. G. Sampaio et al.   JOURNAL OF CELL SCIENCE

Evidence That the Lipid Phosphatase SHIP-1 Regulates T Lymphocyte Morphology and Motility

(2011) S. J. Harris et al.   JOURNAL OF IMMUNOLOGY

Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation

(2011) Christian D. Sadik et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation

(2011) Yu Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Actin cross-linking proteins cortexillin I and II are required for cAMP signaling during Dictyostelium chemotaxis and development

(2011) Shi Shu et al.   MOLECULAR BIOLOGY OF THE CELL

Migfilin and Filamin as Regulators of Integrin Activation in Endothelial Cells and Neutrophils

(2011) Mitali Das et al.   PLoS One

Adhesive F-actin Waves: A Novel Integrin-Mediated Adhesion Complex Coupled to Ventral Actin Polymerization

(2011) Lindsay B. Case et al.   PLoS One

Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour

(2011) Matthew P. Neilson et al.   PLOS BIOLOGY

Activated Membrane Patches Guide Chemotactic Cell Motility

(2011) Inbal Hecht et al.   PLoS Computational Biology

Akt isoforms differentially regulate neutrophil functions

(2010) J. Chen et al.   BLOOD

The actin gene family: Function follows isoform

(2010) Benjamin J. Perrin et al.   Cytoskeleton

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

(2010) Lunhua Liu et al.   DEVELOPMENTAL CELL

A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration

(2010) Pascale G. Charest et al.   DEVELOPMENTAL CELL

Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

(2010) Sa Kan Yoo et al.   DEVELOPMENTAL CELL

An MEK-cofilin signalling module controls migration of human T cells in 3D but not 2D environments

(2010) Martin Klemke et al.   EMBO JOURNAL

MEK signalling tunes actin treadmilling for interstitial lymphocyte migration

(2010) Michele Weber et al.   EMBO JOURNAL

Determinants of RasC Specificity duringDictyosteliumAggregation

(2010) Parvin Bolourani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide-dependent Protein Kinase (PDK) Activity Regulates Phosphatidylinositol 3,4,5-Trisphosphate-dependent and -independent Protein Kinase B Activation and Chemotaxis

(2010) Yoichiro Kamimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

(2010) Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Y53A-Actin inDictyosteliumDisrupts the Cytoskeleton and Inhibits Intracellular and Intercellular Chemotactic Signaling

(2010) Shi Shu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

(2010) Huaqing Cai et al.   JOURNAL OF CELL BIOLOGY

Chemotaxis: insights from the extending pseudopod

(2010) P. J. M. Van Haastert   JOURNAL OF CELL SCIENCE

Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2

(2010) Xin-Hua Liao et al.   JOURNAL OF CELL SCIENCE

P-Rex1 and Vav1 Cooperate in the Regulation of Formyl-Methionyl-Leucyl-Phenylalanine-Dependent Neutrophil Responses

(2010) C. D. Lawson et al.   JOURNAL OF IMMUNOLOGY

Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro

(2010) Angelo Y Meliton et al.   Journal of Inflammation-London

Glycogen Synthase Kinase-3 Is Required for Efficient Dictyostelium Chemotaxis

(2010) Regina Teo et al.   MOLECULAR BIOLOGY OF THE CELL

A Rap/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation

(2010) Arjan Kortholt et al.   MOLECULAR BIOLOGY OF THE CELL

Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN

(2010) Ming Tang et al.   MOLECULAR BIOLOGY OF THE CELL

Chemoattractant-mediated Rap1 activation requires GPCR/G proteins

(2010) Injun Cha et al.   MOLECULES AND CELLS

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phenomenological approach to eukaryotic chemotactic efficiency

(2010) Bo Hu et al.   PHYSICAL REVIEW E

Transient Localized Patterns in Noise-Driven Reaction-Diffusion Systems

(2010) Inbal Hecht et al.   PHYSICAL REVIEW LETTERS

Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells

(2010) Aya Takesono et al.   PLoS One

Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum

(2010) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cells navigate with a local-excitation, global-inhibition-biased excitable network

(2010) Y. Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-organization of the phosphatidylinositol lipids signaling system for random cell migration

(2010) Y. Arai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ancient origin of the integrin-mediated adhesion and signaling machinery

(2010) A. Sebe-Pedros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translating environmental gradients into discontinuous reaction norms via hormone signalling in a polyphenic butterfly

(2010) V. Oostra et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Coupling Mechanism of a GPCR and a Heterotrimeric G Protein During Chemoattractant Gradient Sensing in Dictyostelium

(2010) X. Xu et al.   Science Signaling

Actin-cytoskeleton dynamics in non-monotonic cell spreading

(2010) Doris Heinrich et al.   Cell Adhesion & Migration

Self-organizing actin waves as planar phagocytic cup structures

(2010) Guenther Gerisch et al.   Cell Adhesion & Migration

The Three-Dimensional Dynamics of Actin Waves, a Model of Cytoskeletal Self-Organization

(2009) Till Bretschneider et al.   BIOPHYSICAL JOURNAL

Adhesion Between Human Neutrophils and Immobilized Endothelial Ligand Vascular Cell Adhesion Molecule 1: Divalent Ion Effects

(2009) Elena B. Lomakina et al.   BIOPHYSICAL JOURNAL

The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration

(2009) A. Gerard et al.   BLOOD

Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein

(2009) Alice Y Pollitt et al.   BMC CELL BIOLOGY

Desensitization of vascular endothelin receptors by G protein-coupled receptor kinase 2

(2009) Y.-J. Gao   CARDIOVASCULAR RESEARCH

Chemokines in the vascular inflammatory response of atherosclerosis

(2009) A. Zernecke et al.   CARDIOVASCULAR RESEARCH

Neutrophils Establish Rapid and Robust WAVE Complex Polarity in an Actin-Dependent Fashion

(2009) Arthur Millius et al.   CURRENT BIOLOGY

Mechanical modes of ‘amoeboid’ cell migration

(2009) Tim Lämmermann et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of Dictyostelium morphogenesis by RapGAP3

(2009) Taeck J. Jeon et al.   DEVELOPMENTAL BIOLOGY

Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium

(2009) K. Parkinson et al.   JOURNAL OF CELL SCIENCE

The cofilin activity cycle in lamellipodia and invadopodia

(2009) Matthew Oser et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PDK1 Regulates Chemotaxis in Human Neutrophils

(2009) M. Yagi et al.   JOURNAL OF DENTAL RESEARCH

The mDial Formin Is Required for Neutrophil Polarization, Migration, and Activation of the LARG/RhoA/ROCK Signaling Axis during Chemotaxis

(2009) Y. Shi et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation

(2009) B. Sarraj et al.   JOURNAL OF IMMUNOLOGY

A Cell-Intrinsic Role for Mst1 in Regulating Thymocyte Egress

(2009) Y. Dong et al.   JOURNAL OF IMMUNOLOGY

Non-muscle myosin II takes centre stage in cell adhesion and migration

(2009) Miguel Vicente-Manzanares et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dictyostelium discoideum Paxillin Regulates Actin-Based Processes

(2009) M. Berenice Duran et al.   PROTIST

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

(2009) A. Nishikimi et al.   SCIENCE

TOR complex 2: a signaling pathway of its own

(2009) Nadine Cybulski et al.   TRENDS IN BIOCHEMICAL SCIENCES

The effects of extracellular calcium on motility, pseudopod and uropod formation, chemotaxis, and the cortical localization of myosin II inDictyostelium discoideum

(2009) Daniel F. Lusche et al.   CELL MOTILITY AND THE CYTOSKELETON

Spatiotemporal Regulation of Ras Activity Provides Directional Sensing

(2008) Sheng Zhang et al.   CURRENT BIOLOGY

PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis

(2008) Yoichiro Kamimura et al.   CURRENT BIOLOGY

Chemotaxis, chemokine receptors and human disease

(2008) Tian Jin et al.   CYTOKINE

Involvement of Sib Proteins in the Regulation of Cellular Adhesion inDictyostelium discoideum

(2008) Sophie Cornillon et al.   EUKARYOTIC CELL

Overlapping Functions of the Two Talin Homologues inDictyostelium

(2008) Masatsune Tsujioka et al.   EUKARYOTIC CELL

tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis

(2008) L. Tang et al.   GENES & DEVELOPMENT

Rap1 Activation in Response to cAMP Occurs Downstream of Ras Activation duringDictyosteliumAggregation

(2008) Parvin Bolourani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking Ras to myosin function: RasGEF Q, aDictyosteliumexchange factor for RasB, affects myosin II functions

(2008) Subhanjan Mondal et al.   JOURNAL OF CELL BIOLOGY

PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients

(2008) L. Bosgraaf et al.   JOURNAL OF CELL SCIENCE

The multi-FERM-domain-containing protein FrmA is required for turnover of paxillin-adhesion sites during cell migration of Dictyostelium

(2008) H. Patel et al.   JOURNAL OF CELL SCIENCE

Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration

(2008) Nicole A. Morin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

iPLA2β: front and center in human monocyte chemotaxis to MCP-1

(2008) Ravi S. Mishra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RACK1 Regulates Directional Cell Migration by Acting on Gβγ at the Interface with Its Effectors PLCβ and PI3Kγ

(2008) Songhai Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Dictyostelium Dock180-related RacGEFs Regulate the Actin Cytoskeleton during Cell Motility

(2008) Alessia Para et al.   MOLECULAR BIOLOGY OF THE CELL

How chemokines invite leukocytes to dance

(2008) Marcus Thelen et al.   NATURE IMMUNOLOGY

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS

Persistent Cell Motion in the Absence of External Signals: A Search Strategy for Eukaryotic Cells

(2008) Liang Li et al.   PLoS One

The Actinome of Dictyostelium discoideum in Comparison to Actins and Actin-Related Proteins from Other Organisms

(2008) Jayabalan M. Joseph et al.   PLoS One

Functional Analysis of Spontaneous Cell Movement under Different Physiological Conditions

(2008) Hiroaki Takagi et al.   PLoS One

Correlated waves of actin filaments and PIP3inDictyosteliumcells

(2008) Yukako Asano et al.   CELL MOTILITY AND THE CYTOSKELETON

Chemokines and Their Receptors: Drug Targets in Immunity and Inflammation

(2007) Antonella Viola et al.   Annual Review of Pharmacology and Toxicology