Article
Mathematics, Applied
Yu Tian, Michael Winkler
Summary: This article investigates the chemotaxis-Stokes system with homogeneous boundary conditions of no-flux type for n and c, and of Dirichlet type for u, in a smoothly bounded domain Omega subset of R-2. It is shown that under the given assumptions, a global very weak solution exists for any suitably regular initial data in the associated initial-boundary value problem.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2023)
Review
Microbiology
Vadim M. Gumerov, Ekaterina P. Andrianova, Igor B. Zhulin
Summary: Chemosensory system is a complex and specialized signal transduction mode in bacteria and archaea, which can respond rapidly to environmental changes. Both experimental and computational studies have revealed substantial diversity in system design, functional regulation, cellular localization, and phyletic distribution of chemosensory pathways.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Caralyn E. Flack, John S. Parkinson
Summary: Our study provides important insights into the molecular signaling mechanisms of transmembrane chemoreceptors in Escherichia coli, offering valuable clues for further research in this area.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Mathematics, Applied
Dan Li, Jie Zhao
Summary: This paper discusses the behavior of a chemotaxis-consumption system with signal-dependent motility in a smoothly bounded domain Omega. The study shows that for the case of positive motility function, the system has a unique global classical solution which is uniformly bounded, and the solution exponentially converges to constant equilibria in the large time. Additionally, the existence of weak solution is obtained when the motility function is zero at some point.
ZEITSCHRIFT FUR ANGEWANDTE MATHEMATIK UND PHYSIK
(2021)
Article
Mathematics, Applied
Shuyan Qiu, Chunlai Mu, Xinyu Tu
Summary: This paper examines a two-species chemotaxis-consumption system involving nonlinear diffusion and chemotaxis in a smooth bounded domain in 2D and 3D space. It is shown that the corresponding initial-boundary value problem has a unique global bounded classical solution for sufficiently large values of mu(1), mu(2). The paper also establishes asymptotic stabilization of solutions to the system, with convergence properties dependent on the parameters a(1), a(2).
NONLINEAR ANALYSIS-REAL WORLD APPLICATIONS
(2021)
Article
Biochemical Research Methods
Hye-ran Moon, Soutick Saha, Andrew Mugler, Bumsoo Han
Summary: This study investigated the cellular signal processing machinery by reverse-engineering directed cell migration under integrated chemical and fluidic cues. A cellular signal processing system based on a selection gate was constructed to understand how cells decode multiple cues and make decisions about migration direction.
Article
Multidisciplinary Sciences
Ryosuke Ishiwata, Masatomo Iwasa
Summary: Experimental studies have shown that chemotactic cells have cellular memory, with a tendency to maintain migration direction despite changes in the chemoattractant gradient. A phenomenological model analyzing cellular inertia and response time in motility was used to replicate cellular memory observed in experiments. The agreement between experimental data and theory indicates the potential presence of response time in motility, which warrants further exploration.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Anne Aalto, Adan Olguin-Olguin, Erez Raz
Summary: This article discusses the migration mechanism of zebrafish primordial germ cells during embryonic development, which involves a bleb-driven amoeboid migration mode controlled by chemical and physical cues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elizabet Monteagudo-Cascales, Alvaro Ortega, Felix Velando, Bertrand Morel, Miguel A. Matilla, Tino Krell
Summary: Bacterial signal transduction systems are typically activated by the binding of signal molecules to receptor ligand binding domains (LBDs), such as the NIT LBD. The NIT domain is found in over 15,000 receptors from 30 bacterial phyla and 19 eukaryotic phyla, and it is a part of seven receptor families involved in transcription control, chemotaxis, or second messenger regulation.
MOLECULAR MICROBIOLOGY
(2023)
Article
Microbiology
Marissa A. Berry, Ekaterina P. Andrianova, Igor B. Zhulin
Summary: Chemosensory systems in bacteria and archaea are complex and multi-protein pathways that allow rapid cellular response to environmental changes. CheA histidine kinase, a central component of these systems, lacks a sensor domain and relies on dedicated chemoreceptors for sensing. This study provides a genomic survey of CheA domain composition from thousands of bacteria and archaea, revealing variations and deviations from the canonical architecture. It lays the foundation for better classification of CheA homologs and identifies targets for experimental investigations.
MICROBIOLOGY SPECTRUM
(2023)
Article
Mathematics
Youshan Tao, Michael Winkler
Summary: This manuscript considers the no-flux initial-boundary problem for the migration-consumption system and provides the existence of a weak-strong solution for arbitrary diffusion singularities with suitable initial data. It also presents the conditions for the flux del(u phi(v)) to belong to a reflexive Lebesgue space and for the system to be satisfied in a weak sense. Finally, it derives a statement on global classical solvability in the one-dimensional case under certain conditions on phi.
JOURNAL OF DIFFERENTIAL EQUATIONS
(2023)
Article
Biochemical Research Methods
Hye-ran Moon, Soutick Saha, Andrew Mugler, Bumsoo Han
Summary: Cells sense environmental cues and process signals to determine migration direction. This study investigates the cellular signal processing machinery by reverse engineering cell migration under integrated chemical and fluidic cues. A cellular signal processing system is built based on a selection gate, providing a systematic view of how cells decode multiple cues and make migration decisions.
Article
Multidisciplinary Sciences
Haichao Feng, Yu Lv, Tino Krell, Ruixin Fu, Yunpeng Liu, Zhihui Xu, Wenbin Du, Qirong Shen, Nan Zhang, Ruifu Zhang
Summary: Bacteria have evolved multiple signal transduction systems to adapt to changing environmental conditions. The chemoreceptor McpA of Bacillus velezensis SQR9 has been found to directly bind to 13 chemoattractants. Structural biology studies and mutagenesis experiments have identified key amino acid residues that play roles in recognizing multiple ligands. This discovery reveals a mechanism in which a single chemoreceptor can integrate diverse signals through two modules.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Sana A. A. Fadil, Chris Janetopoulos
Summary: This article explores the mechanisms regulating cell migration during fruiting body formation in Dictyostelium discoideum, finding that cAMP is released through expulsion during contractile vacuole ejection. The vacuole localizes to the rear of the cell and is regulated by membrane lipids, including PI(4,5)P2. The exocyst complex, mediated in part by PI(4,5)P2-binding, is essential for exocytosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amalia Hadjitheodorou, George R. R. Bell, Felix Ellett, Daniel Irimia, Robert Tibshirani, Sean R. Collins, Julie A. Theriot
Summary: Maintaining persistent migration in complex environments is critical for neutrophils to reach infection sites. Neutrophils avoid getting trapped, even when obstacles split their front into multiple leading edges. How they re-establish polarity to move productively while incorporating receptor inputs under such conditions remains unclear. Our study uses symmetric bifurcating microfluidic channels to challenge chemotaxing HL60 neutrophil-like cells and probes cell-intrinsic processes during the resolution of competing fronts. We find that cells commit to one leading edge late in the process rather than amplifying structural asymmetries or early fluctuations, and receptor inputs only bias the decision late, once mechanical stretching weakens each front. The retracting edge commits to retraction, with ROCK limiting sensitivity to receptor inputs until retraction completes. Our results suggest that cell edges locally adopt highly stable protrusion/retraction programs modulated by mechanical feedback.
Article
Gastroenterology & Hepatology
Yang-Yi Fan, Laurie A. Davidson, Evelyn S. Callaway, Gus A. Wright, Stephen Safe, Robert S. Chapkin
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Ana M. Chamoun-Emanuelli, Gus Wright, Smith Roger, Robert C. Muench, Christian J. Buchholz, Zhilei Chen
BIOTECHNOLOGY AND BIOENGINEERING
(2015)
Article
Veterinary Sciences
Brittany Ciepluch, Heather Wilson-Robles, Gwendolyn Levine, Roger Smith, Gus A. Wright, Tasha Miller, Maureen T. O'Brien, Kelley M. Thieman Mankin
VETERINARY SURGERY
(2018)
Article
Microbiology
Nagarjun Kasaraneni, Ana M. Chamoun-Emanuelli, Gus Wright, Zhilei Chen
Article
Agriculture, Dairy & Animal Science
Joao Gatto Brom-de-Luna, Heloisa Siqueira Canesin, Gus Wright, Katrin Hinrichs
ANIMAL REPRODUCTION SCIENCE
(2018)
Article
Oncology
Eunjoo Kim, Gus A. Wright, Roger S. Zoh, Bhimanagouda S. Patil, Guddadarangavvanahally K. Jayaprakasha, Evelyn S. Callaway, Ivan Ivanov, Nancy D. Turner, Robert S. Chapkin
EUROPEAN JOURNAL OF CANCER PREVENTION
(2019)
Article
Materials Science, Multidisciplinary
Yingjun Yan, Liwei Jiang, Karl J. Aufderheide, Gus A. Wright, Alexander Terekhov, Lino Costa, Kevin Qin, W. Tyler McCleery, John J. Fellenstein, Alessandro Ustione, J. Brian Robertson, Carl Hirschie Johnson, David W. Piston, M. Shane Hutson, John P. Wikswo, William Hofmeister, Chris Janetopoulos
MICROSCOPY AND MICROANALYSIS
(2014)
Article
Multidisciplinary Sciences
Nagarjun Kasaraneni, Ana M. Chamoun-Emanuelli, Gus A. Wright, Zhilei Chen
SCIENTIFIC REPORTS
(2018)
Article
Genetics & Heredity
Mark F. Richardson, Kylie Munyard, Larry J. Croft, Theodore R. Allnutt, Felicity Jackling, Fahad Alshanbari, Matthew Jevit, Gus A. Wright, Rhys Cransberg, Ahmed Tibary, Polina Perelman, Belinda Appleton, Terje Raudsepp
FRONTIERS IN GENETICS
(2019)
Article
Biochemical Research Methods
Pete Heinzelman, Alyssa Low, Rudo Simeon, Gus A. Wright, Zhilei Chen
JOURNAL OF BIOLOGICAL ENGINEERING
(2019)
Article
Oncology
Keshav Karki, Gus A. Wright, Kumaravel Mohankumar, Un-Ho Jin, Xing-Han Zhang, Stephen Safe
Article
Genetics & Heredity
Kushal Suryamohan, Sajesh P. Krishnankutty, Joseph Guillory, Matthew Jevit, Markus S. Schroeder, Meng Wu, Boney Kuriakose, Oommen K. Mathew, Rajadurai C. Perumal, Ivan Koludarov, Leonard D. Goldstein, Kate Senger, Mandumpala Davis Dixon, Dinesh Velayutham, Derek Vargas, Subhra Chaudhuri, Megha Muraleedharan, Ridhi Goel, Ying-Jiun J. Chen, Aakrosh Ratan, Peter Liu, Brendan Faherty, Guillermo de la Rosa, Hiroki Shibata, Miriam Baca, Meredith Sagolla, James Ziai, Gus A. Wright, Domagoj Vucic, Sangeetha Mohan, Aju Antony, Jeremy Stinson, Donald S. Kirkpatrick, Rami N. Hannoush, Steffen Durinck, Zora Modrusan, Eric W. Stawiski, Kristen Wiley, Terje Raudsepp, R. Manjunatha Kini, Arun Zachariah, Somasekar Seshagiri
Article
Entomology
Jiaxin Lei, Ivy W. Chen, Gus Wright, Suresh Pillai, Keyan Zhu-Salzman
JOURNAL OF PEST SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Huajun Han, Laurie A. Davidson, Yang-Yi Fan, Jennifer S. Goldsby, Grace Yoon, Un-Ho Jin, Gus A. Wright, Kerstin K. Landrock, Bradley R. Weeks, Rachel C. Wright, Clinton D. Allred, Arul Jayaraman, Ivan Ivanov, Jatin Roper, Stephen H. Safe, Robert S. Chapkin
Article
Biochemistry & Molecular Biology
Carmen H. Lau, Drew Pendleton, Nicholas L. Drury, Jiayun Zhao, Yixin Li, Renyi Zhang, Gus A. Wright, Aline Rodrigues Hoffmann, Natalie M. Johnson
Summary: Early life exposure to particulate matter air pollution negatively affects neonatal health. This study evaluated the role of Nrf2 in response to prenatal exposure to ultrafine particles (UFP) and found that the lack of Nrf2 leads to growth inhibitory effects and a skewed immune response towards Th2 in neonates.