Transient dynamics of Aβ contribute to toxicity in Alzheimer’s disease

Simulations of monomeric amyloid β-peptide (1–40) with varying solution conditions and oxidation state of Met35: Implications for aggregation

(2014) Anne M. Brown et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

(2014) Samuel A. Kotler et al.   CHEMICAL SOCIETY REVIEWS

The triple power of D³: Protein intrinsic disorder in degenerative diseases

(2014) Vladimir Uversky   Frontiers in Bioscience-Landmark

Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX Trial): Rationale and Design

(2014) Kristine Hoffmann et al.   NEUROEPIDEMIOLOGY

Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy

(2013) Robert Tycko et al.   ACCOUNTS OF CHEMICAL RESEARCH

Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits

(2013) Sofie Nyström et al.   ACS Chemical Biology

Intrinsic Structural Heterogeneity and Long-Term Maturation of Amyloid β Peptide Fibrils

(2013) Jianqiang Ma et al.   ACS Chemical Neuroscience

The BRICHOS Domain, Amyloid Fibril Formation, and Their Relationship

(2013) Stefan D. Knight et al.   BIOCHEMISTRY

Resolution of Oligomeric Species during the Aggregation of Aβ1–40 Using 19F NMR

(2013) Yuta Suzuki et al.   BIOCHEMISTRY

Single-Molecule Imaging Reveals Aβ42:Aβ40 Ratio-Dependent Oligomer Growth on Neuronal Processes

(2013) Robin D. Johnson et al.   BIOPHYSICAL JOURNAL

Structural Characterization and Inhibition of Toxic Amyloid-β Oligomeric Intermediates

(2013) Ayyalusamy Ramamoorthy et al.   BIOPHYSICAL JOURNAL

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

The effect of exercise interventions on cognitive outcome in Alzheimer's disease: a systematic review

(2013) Nicolas Farina et al.   INTERNATIONAL PSYCHOGERIATRICS

Signature Amyloid β Profiles Are Produced by Different γ-Secretase Complexes

(2013) Hermien Acx et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into Aβ42 Oligomers Using Site-directed Spin Labeling

(2013) Lei Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ Monomers Transiently Sample Oligomer and Fibril-Like Configurations: Ensemble Characterization Using a Combined MD/NMR Approach

(2013) David J. Rosenman et al.   JOURNAL OF MOLECULAR BIOLOGY

Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

(2013) Lei Gu et al.   JOURNAL OF NEUROCHEMISTRY

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polymorph-Specific Kinetics and Thermodynamics of β-Amyloid Fibril Growth

(2013) Wei Qiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The missing link in the amyloid cascade of Alzheimer’s disease – Metal ions

(2013) Ann Tiiman et al.   NEUROCHEMISTRY INTERNATIONAL

Environmental Novelty Activates β2-Adrenergic Signaling to Prevent the Impairment of Hippocampal LTP by Aβ Oligomers

(2013) Shaomin Li et al.   NEURON

Pulsed hydrogen–deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation

(2013) Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

(2013) Angélique Deleersnijder et al.   TRENDS IN MOLECULAR MEDICINE

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

On the subject of rigor in the study of amyloid β-protein assembly

(2013) David B Teplow   Alzheimers Research & Therapy

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Biophysical Insights into How Surfaces, Including Lipid Membranes, Modulate Protein Aggregation Related to Neurodegeneration

(2013) Kathleen A. Burke et al.   Frontiers in Neurology

Alzheimer’s Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways

(2012) Tiago Silva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

(2012) María Soledad Celej et al.   BIOCHEMICAL JOURNAL

Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

(2012) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Metal-associated amyloid-β species in Alzheimer's disease

(2012) Amit S Pithadia et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A comparative analysis of the aggregation behavior of amyloid-β peptide variants

(2012) Annelies Vandersteen et al.   FEBS LETTERS

Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity

(2012) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Plasticity Regulates Oligomerization and Cytotoxicity of the Multipeptide-length Amyloid-β Peptide Pool

(2012) Annelies Vandersteen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Side-Chain Dynamics Reveals Transient Association of Aβ1–40 Monomers with Amyloid Fibers

(2012) Janarthanan Krishnamoorthy et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Antiparallel  -sheet architecture in Iowa-mutant  -amyloid fibrils

(2012) W. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical

(2012) Scott D. Smid et al.   Food & Function

Solid-State NMR Spectroscopic Investigation of Aβ Protofibrils: Implication of a β-Sheet Remodeling upon Maturation into Terminal Amyloid Fibrils

(2011) Holger A. Scheidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A partially folded structure of amyloid-beta(1–40) in an aqueous environment

(2011) Subramanian Vivekanandan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes

(2011) Thomas L. Williams et al.   BIOCHEMICAL JOURNAL

Effect of Zinc Binding on β-Amyloid Structure and Dynamics: Implications for Aβ Aggregation

(2011) Nasrollah Rezaei-Ghaleh et al.   BIOPHYSICAL JOURNAL

Misfolded proteins in Alzheimer's disease and type II diabetes

(2011) Alaina S. DeToma et al.   CHEMICAL SOCIETY REVIEWS

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

(2011) Sathish Kumar et al.   EMBO JOURNAL

Membrane and surface interactions of Alzheimer’s Aβ peptide - insights into the mechanism of cytotoxicity

(2011) Thomas L. Williams et al.   FEBS Journal

Dynamics of Amyloid β Fibrils Revealed by Solid-state NMR

(2011) Holger A. Scheidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40Ratios in Alzheimer Disease

(2011) Kris Pauwels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

(2011) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Structural Model of Aβ40Fibrils

(2011) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

(2011) Rakez Kayed et al.   Molecular Neurodegeneration

Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR

(2011) Nicolas L. Fawzi et al.   NATURE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: A multi-electrode array study

(2011) Seon-Ah Chong et al.   NEUROBIOLOGY OF DISEASE

Aβ Peptide Fibrillar Architectures Controlled by Conformational Constraints of the Monomer

(2011) Kristoffer Brännström et al.   PLoS One

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Intermolecular Dynamics of Aggregates Populated during Amyloid Fibril Formation Studied by Hydrogen/Deuterium Exchange

(2010) Natàlia Carulla et al.   ACCOUNTS OF CHEMICAL RESEARCH

ANS Binding Reveals Common Features of Cytotoxic Amyloid Species

(2010) Benedetta Bolognesi et al.   ACS Chemical Biology

Size-dependent neurotoxicity of β-amyloid oligomers

(2010) Paulius Cizas et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Alzheimer's disease and amyloid β-peptide deposition in the brain: a matter of ‘aging’?

(2010) Maria Luisa Moro et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Transformation of amyloid β(1–40) oligomers into fibrils is characterized by a major change in secondary structure

(2010) Rabia Sarroukh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

(2010) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ(1–40) Forms Five Distinct Amyloid Structures whose β-Sheet Contents and Fibril Stabilities Are Correlated

(2010) Ravindra Kodali et al.   JOURNAL OF MOLECULAR BIOLOGY

Atomic-Level Characterization of the Ensemble of the Aβ(1–42) Monomer in Water Using Unbiased Molecular Dynamics Simulations and Spectral Algorithms

(2010) Nikolaos G. Sgourakis et al.   JOURNAL OF MOLECULAR BIOLOGY

The Thermodynamic Stability of Amyloid Fibrils Studied by Differential Scanning Calorimetry

(2010) Bertrand Morel et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Kinetics of Amyloid β Monomer-to-Oligomer Exchange by NMR Relaxation

(2010) Nicolas L. Fawzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

A causative link between the structure of aberrant protein oligomers and their toxicity

(2010) Silvia Campioni et al.   Nature Chemical Biology

Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research

(2010) Asad Jan et al.   Nature Protocols

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural polymorphism of Alzheimer Aβ and other amyloid fibrils

(2010) Marcus Fändrich et al.   Prion

Fibril fragmentation in amyloid assembly and cytotoxicity

(2010) Wei-Feng Xue et al.   Prion

The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

(2010) Kerensa Broersen et al.   Alzheimers Research & Therapy

Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

(2009) Emilie Cerf et al.   BIOCHEMICAL JOURNAL

The interaction of beta-amyloid protein with cellular membranes stimulates its own production

(2009) Imke Peters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural disorder in amyloid fibrils: its implication in dynamic interactions of proteins

(2009) P. Tompa   FEBS Journal

The Recombinant Amyloid-β Peptide Aβ1–42 Aggregates Faster and Is More Neurotoxic than Synthetic Aβ1–42

(2009) Verena H. Finder et al.   JOURNAL OF MOLECULAR BIOLOGY

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Interprotofilament interactions between Alzheimer's A 1-42 peptides in amyloid fibrils revealed by cryoEM

(2009) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Alzheimer A (1-40) and A (1-42) amyloid fibrils reveals similar protofilament structures

(2009) M. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

(2009) Y. Nekooki-Machida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Protein aggregation kinetics, mechanism, and curve-fitting: A review of the literature

(2008) Aimee M. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

(2008) Rakez Kayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity

(2008) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone signalling complexes in Alzheimer's disease

(2008) John Koren et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amyloid β-Protein Monomer Folding: Free-Energy Surfaces Reveal Alloform-Specific Differences

(2008) Mingfeng Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Aβ(1-40) Fibril Polymorphism Implies Diverse Interaction Patterns in Amyloid Fibrils

(2008) Jessica Meinhardt et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Amyloid fibril composition is related to the phenotype of hereditary transthyretin V30M amyloidosis

(2008) E Ihse et al.   JOURNAL OF PATHOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

(2008) Tara L. Spires-Jones et al.   NEUROBIOLOGY OF DISEASE

Paired  -sheet structure of an A (1-40) amyloid fibril revealed by electron microscopy

(2008) C. Sachse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the nucleation of amyloid β-protein monomer folding

(2005) Noel D. Lazo et al.   PROTEIN SCIENCE