Current understanding of ZIP and ZnT zinc transporters in human health and diseases

Zinc Supplementation in Public Health

(2013) Mary Edith Penny   ANNALS OF NUTRITION AND METABOLISM

A mechanism for epithelial–mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3)

(2013) Christer Hogstrand et al.   BIOCHEMICAL JOURNAL

Allosteric modulation of zinc speciation by fatty acids

(2013) James P. Barnett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Zinc signals and immune function

(2013) Hajo Haase et al.   BIOFACTORS

Granulocyte Macrophage-Colony Stimulating Factor Induced Zn Sequestration Enhances Macrophage Superoxide and Limits Intracellular Pathogen Survival

(2013) Kavitha Subramanian Vignesh et al.   IMMUNITY

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

(2013) Motoyuki Tamaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Synaptic Zn2+ homeostasis and its significance

(2013) Atsushi Takeda et al.   Metallomics

Zinc transporters in prostate cancer

(2013) M.-C. Franz et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC39 family of zinc transporters

(2013) Jeeyon Jeong et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC30 family of zinc transporters – A review of current understanding of their biological and pathophysiological roles

(2013) Liping Huang et al.   MOLECULAR ASPECTS OF MEDICINE

Zinc and zinc transporters in prostate carcinogenesis

(2013) Vladimir Kolenko et al.   Nature Reviews Urology

ZIP4 is a novel molecular marker for glioma

(2013) Y. Lin et al.   NEURO-ONCOLOGY

Negative Correlation of LIV-1 and E-Cadherin Expression in Hepatocellular Carcinoma Cells

(2013) Rongxi Shen et al.   PLoS One

Essential Role of the Zinc Transporter ZIP9/SLC39A9 in Regulating the Activations of Akt and Erk in B-Cell Receptor Signaling Pathway in DT40 Cells

(2013) Masanari Taniguchi et al.   PLoS One

Compound Heterozygous Mutations in SLC30A2/ZnT2 Results in Low Milk Zinc Concentrations: A Novel Mechanism for Zinc Deficiency in a Breast-Fed Infant

(2013) Naoya Itsumura et al.   PLoS One

Altered Expression of ZnT10 in Alzheimer's Disease Brain

(2013) Helen J. Bosomworth et al.   PLoS One

Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway

(2013) Shigeyuki Fujimoto et al.   PLoS One

Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy

(2013) N. Coudray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Neonatal Zinc Deficiency Caused by a Heterozygous G87R Mutation in theZinc Transporter ZnT-2 (SLC30A2)Gene in the Mother Highlighting the Importance of Zn2+for Normal Growth and Development

(2013) Maria Consolata Miletta et al.   International Journal of Endocrinology

ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB

(2013) Ming-Jie Liu et al.   Cell Reports

Zinc homeostasis and neurodegenerative disorders

(2013) Bernadeta Szewczyk   Frontiers in Aging Neuroscience

Zinc Sequestration: Arming Phagocyte Defense against Fungal Attack

(2013) Kavitha Subramanian Vignesh et al.   PLoS Pathogens

Zinc-binding and structural properties of the histidine-rich loop of Arabidopsis thaliana vacuolar membrane zinc transporter MTP1

(2013) Natsuki Tanaka et al.   FEBS Open Bio

Zinc: dietary intake and impact of supplementation on immune function in elderly

(2012) Eugenio Mocchegiani et al.   AGE

Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver Disease

(2012) Marialuisa Quadri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10 , a Manganese Transporter in Man

(2012) Karin Tuschl et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8

(2012) A. B. Hardy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Human ZIP4 Transporter Has Two Distinct Binding Affinities and Mediates Transport of Multiple Transition Metals

(2012) Sagar Antala et al.   BIOCHEMISTRY

Zinc networks: the cell-specific compartmentalization of zinc for specialized functions

(2012) Stephen R. Hennigar et al.   BIOLOGICAL CHEMISTRY

Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study

(2012) A. J. Delli et al.   DIABETES

Polymorphisms of SLC30A2 and selected perinatal factors associated with low milk zinc in Chinese breastfeeding women

(2012) Linxi Qian et al.   EARLY HUMAN DEVELOPMENT

A Dominant Negative Heterozygous G87R Mutation in the Zinc Transporter, ZnT-2 (SLC30A2), Results in Transient Neonatal Zinc Deficiency

(2012) Inbal Lasry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency

(2012) Tatsuyoshi Kawamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis

(2012) Helen J. Bosomworth et al.   Metallomics

Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells

(2012) Hitomi Fujishiro et al.   Metallomics

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Angiotensin II Requires Zinc and Downregulation of the Zinc Transporters ZnT3 and ZnT10 to Induce Senescence of Vascular Smooth Muscle Cells

(2012) Nikolay Patrushev et al.   PLoS One

The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background

(2012) Lynley D. Pound et al.   PLoS One

Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome

(2012) J. Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity

(2012) E. Hoch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mouse Model of Acrodermatitis Enteropathica: Loss of Intestine Zinc Transporter ZIP4 (Slc39a4) Disrupts the Stem Cell Niche and Intestine Integrity

(2012) Jim Geiser et al.   PLoS Genetics

A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission

(2011) Beth Y Besecker et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

An Overview of a Wide Range of Functions of ZnT and Zip Zinc Transporters in the Secretory Pathway

(2011) Taiho KAMBE   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma

(2011) J. Gumulec et al.   CURRENT MEDICINAL CHEMISTRY

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease

(2011) Anne Rovelet-Lecrux et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Multi-ethnic studies in complex traits

(2011) Jingyuan Fu et al.   HUMAN MOLECULAR GENETICS

Metal Binding Ability of Cysteine-Rich Peptide Domain of ZIP13 Zn2+Ions Transporter

(2011) Slawomir Potocki et al.   INORGANIC CHEMISTRY

Metal Selectivity Determinants in a Family of Transition Metal Transporters

(2011) Dorina Podar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue Nonspecific Alkaline Phosphatase Is Activated via a Two-step Mechanism by Zinc Transport Complexes in the Early Secretory Pathway

(2011) Ayako Fukunaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Characterization of Human ZIP13 Protein

(2011) Bum-Ho Bin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of T cell receptor signaling by activation-induced zinc influx

(2011) Mingcan Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Type 1 Diabetes Is Associated with T Cell Autoimmunity to Zinc Transporter 8

(2011) M. Dang et al.   JOURNAL OF IMMUNOLOGY

The Neurophysiology and Pathology of Brain Zinc

(2011) S. L. Sensi et al.   JOURNAL OF NEUROSCIENCE

Patterns of levels of biological metals in CSF differ among neurodegenerative diseases

(2011) Isao Hozumi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Molecular and genetic features of zinc transporters in physiology and pathogenesis

(2011) Toshiyuki Fukada et al.   Metallomics

Minimal Functional Sites Allow a Classification of Zinc Sites in Proteins

(2011) Claudia Andreini et al.   PLoS One

The role of zinc transporter ZIP4 in prostate carcinoma

(2011) Qi-guang Chen et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Infantile zinc deficiency: Association with autism spectrum disorders

(2011) Hiroshi Yasuda et al.   Scientific Reports

One novel homozygous mutation of SLC39A4 gene in a Chinese patient with acrodermatitis enteropathica

(2010) Cheng-Rang Li et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Zinc, zinc transporters and diabetes

(2010) J. Rungby   DIABETOLOGIA

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

Zinc is decreased in prostate cancer: an established relationship of prostate cancer!

(2010) Leslie C. Costello et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

8-Amino-Adenosine Inhibits Multiple Mechanisms of Transcription

(2010) J. A. Frey et al.   MOLECULAR CANCER THERAPEUTICS

Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets

(2010) Stéphane Cauchi et al.   MOLECULAR GENETICS AND METABOLISM

ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brain

(2010) Nancy Beyer et al.   Molecular Neurodegeneration

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Functional analysis of two single nucleotide polymorphisms in SLC30A2 (ZnT2): implications for mammary gland function and breast disease in women

(2010) Young Ah Seo et al.   PHYSIOLOGICAL GENOMICS

Zip4 (Slc39a4) Expression is Activated in Hepatocellular Carcinomas and Functions to Repress Apoptosis, Enhance Cell Cycle and Increase Migration

(2010) Benjamin P. Weaver et al.   PLoS One

Krüppel-like factor 4 regulates adaptive expression of the zinc transporter Zip4 in mouse small intestine

(2009) Juan P. Liuzzi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Functional Significance of Zinc-Related Signaling Pathways in Immune Cells

(2009) Hajo Haase et al.   Annual Review of Nutrition

Mammalian Zinc Transporters: Nutritional and Physiologic Regulation

(2009) Louis A. Lichten et al.   Annual Review of Nutrition

Deletion of the mouseSlc30a8gene encoding zinc transporter-8 results in impaired insulin secretion

(2009) Lynley D. Pound et al.   BIOCHEMICAL JOURNAL

SLC39A9 (ZIP9) Regulates Zinc Homeostasis in the Secretory Pathway: Characterization of the ZIP Subfamily I Protein in Vertebrate Cells

(2009) Wataru MATSUURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Coordination Dynamics of Zinc in Proteins

(2009) Wolfgang Maret et al.   CHEMICAL REVIEWS

Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men

(2009) A. Stancakova et al.   DIABETES

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

Zinc Transporter 8 Antibodies Complement GAD and IA-2 Antibodies in the Identification and Characterization of Adult-Onset Autoimmune Diabetes: Non Insulin Requiring Autoimmune Diabetes (NIRAD) 4

(2009) V. Lampasona et al.   DIABETES CARE

An update on mutations of theSLC39A4gene in acrodermatitis enteropathica

(2009) Sébastien Schmitt et al.   HUMAN MUTATION

Identification of the Zn2+Binding Site and Mode of Operation of a Mammalian Zn2+Transporter

(2009) Ehud Ohana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration and Characterization of the Heterodimerization of ZnT5 and ZnT6 in the Early Secretory Pathway

(2009) Ayako Fukunaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells

(2009) Tolunay B. Aydemir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Diarrhoea: why children are still dying and what can be done

(2009) Tessa Wardlaw et al.   LANCET

The EVER Proteins as a Natural Barrier against Papillomaviruses: a New Insight into the Pathogenesis of Human Papillomavirus Infections

(2009) M. Lazarczyk et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Zinc in the physiology and pathology of the CNS

(2009) Stefano L. Sensi et al.   NATURE REVIEWS NEUROSCIENCE

Structural basis for autoregulation of the zinc transporter YiiP

(2009) Min Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation

(2009) C. Hogstrand et al.   TRENDS IN MOLECULAR MEDICINE

Spondylocheiro Dysplastic Form of the Ehlers-Danlos Syndrome—An Autosomal-Recessive Entity Caused by Mutations in the Zinc Transporter Gene SLC39A13

(2008) Cecilia Giunta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation and function ofZip4, the acrodermatitis enteropathica gene

(2008) Glen K. Andrews   BIOCHEMICAL SOCIETY TRANSACTIONS

Ehlers-Danlos syndrome – a historical review

(2008) Liakat A. Parapia et al.   BRITISH JOURNAL OF HAEMATOLOGY

Intracellular zinc homeostasis and zinc signaling

(2008) Masaaki Murakami et al.   CANCER SCIENCE

A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes

(2008) J. M. Wenzlau et al.   DIABETES

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

(2008) K. Kirchhoff et al.   DIABETOLOGIA

Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes

(2008) E. Kawasaki et al.   DIABETOLOGIA

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study

(2008) T. W. Boesgaard et al.   DIABETOLOGIA

ZIP7-Mediated Intracellular Zinc Transport Contributes to Aberrant Growth Factor Signaling in Antihormone-Resistant Breast Cancer Cells

(2008) Kathryn M. Taylor et al.   ENDOCRINOLOGY

The genetics of essential metal homeostasis during development

(2008) Taiho Kambe et al.   GENESIS

Novel Proteolytic Processing of the Ectodomain of the Zinc Transporter ZIP4 (SLC39A4) during Zinc Deficiency Is Inhibited by Acrodermatitis Enteropathica Mutations

(2008) T. Kambe et al.   MOLECULAR AND CELLULAR BIOLOGY

Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter

(2008) K. Girijashanker et al.   MOLECULAR PHARMACOLOGY

The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways

(2008) Toshiyuki Fukada et al.   PLoS One

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

(2008) Brian D. Corbin et al.   SCIENCE

Zinc in gastrointestinal and liver disease

(2007) Gavino Faa et al.   COORDINATION CHEMISTRY REVIEWS

TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation

(2007) Peter Uciechowski et al.   EXPERIMENTAL GERONTOLOGY