Review
Nutrition & Dietetics
Chandra K. Singh, Gagan Chhabra, Arth Patel, Hao Chang, Nihal Ahmad
Summary: Studies have shown the importance of zinc in prostate biology and functions, with high concentrations in healthy prostates and decreased levels in prostate cancer. Zinc supplementation may not effectively increase zinc concentrations in PCa, possibly due to dysregulation of zinc transporters. Natural dietary phytochemicals may modulate zinc levels and combined with zinc, could potentially inhibit prostate cancer.
Article
Multidisciplinary Sciences
Morten Beck Rye, Sebastian Krossa, Martina Hall, Casper van Mourik, Tone F. Bathen, Finn Drablos, May-Britt Tessem, Helena Bertilsson
Summary: This study created a gene signature connected to citrate and spermine secretion in the prostate, and validated its accuracy by integrating metabolic measurements with multiple transcriptomics datasets. Several genes not previously studied in the prostate were highlighted by the signature.
Article
Biochemistry & Molecular Biology
Stephanie MacKenzie, Andreas Bergdahl
Summary: Oxidative stress is a major factor in the development of diabetes and its complications, and zinc plays a significant role in protecting against this stress. Zinc dysregulation is associated with diabetes and may contribute to vascular changes caused by the disease. Zinc supplementation has been shown to be beneficial in preventing and mitigating oxidative stress and its consequences.
Article
Agriculture, Multidisciplinary
Nan Li, Ruiyan Wang, Zeyuan Deng, Jianqun Zhou, Wenwen Li, Qian Du, Liufeng Zheng
Summary: Sucrose is shown to be a stable metal-ion chelating agent that can enhance the absorption of metal ions. This study explores the structure of the zinc-sucrose complex and its ability to promote zinc absorption in cells and mice. The complex increases zinc uptake and transport, upregulates genes and proteins involved in zinc absorption, and interacts with zinc transport proteins. These findings offer valuable insights into the mechanisms of zinc absorption and suggest potential applications in treating zinc deficiency.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Nishi Karunasinghe
Summary: This article mainly discusses the value of zinc in prostate health and disease, as well as the potential impact of zinc marker variations associated with prostate cancer on screening, prognosis, and management. The role of zinc in prostate health and disease is multidimensional, therefore more personalized zinc requirements may be beneficial.
Review
Chemistry, Multidisciplinary
Hai-tao Yu, Juan Zhen, Ji-yan Leng, Lu Cai, Hong-lei Ji, Bradley B. Keller
Summary: Cadmium is a significant environmental pollutant linked to various health issues, while zinc has been shown to alleviate cadmium toxicity through mechanisms like direct competition for cellular uptake and induction of protective mechanisms. Future research directions on the role of zinc and metal transporters in reducing cadmium toxicity are discussed in this review.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Biochemistry & Molecular Biology
Zubaidah Al-Khafaji, Sofia Brito, Bum-Ho Bin
Summary: This article discusses the importance of zinc in maintaining healthy skin and the role of zinc transporters in regulating zinc homeostasis. Zinc deficiency can lead to various skin disorders, but the use of zinc-containing compounds can effectively treat and protect the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Hija Athman Katimba, Rongchun Wang, Cuiling Cheng, Yingchun Zhang, Weihong Lu, Ying Ma
Summary: Zinc is crucial for maintaining the overall well-being of the human body due to its various functions. Disturbances in zinc homeostasis are associated with several diseases and disorders. This review provides an overview of zinc absorption and homeostasis, including the factors affecting absorption and the body's mechanisms to maintain zinc homeostasis.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Nutrition & Dietetics
Zheng Qu, Qiang Liu, Xiangyi Kong, Xiangyu Wang, Zhongzhao Wang, Jing Wang, Yi Fang
Summary: Breast cancer is the most common cancer worldwide, and there is a need for new treatment approaches. Zinc is involved in regulating various processes in the human body, and abnormal zinc homeostasis can contribute to breast cancer. This review focuses on the role of zinc transporters in breast cancer pathogenesis, apoptosis, signal transduction, and potential clinical applications. The translation of zinc-related molecules and drug targets in breast cancer treatment is also discussed, providing insights for diagnosis and management.
Review
Cell Biology
Belma Turan, Erkan Tuncay
Summary: Mitochondria play a crucial role in maintaining cellular Zn2+ homeostasis and signaling in cardiomyocytes, affecting ROS production and redistribution of Zn2+ transporters under pathological conditions. Understanding the role of mitochondria in regulating Zn2+ levels may highlight the importance of new mitochondria-targeting agents for preventing and treating cardiovascular dysfunction in humans.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ceylan Bitirim
Summary: Early diagnosis of HCC relies on zinc levels, with zinc deficiency being a key event in tumor formation and malignancy development. Molecular factors involved in zinc homeostasis could provide clues to the transition from cirrhosis to hepatic tumor formation. Zinc transporter proteins may play a role in the progression and malignancy of HCC.
Article
Plant Sciences
Jia-Dong Chang, Sheng Huang, Indi Wiseno, Fu-Qing Sui, Fan Feng, Luqing Zheng, Jian Feng Ma, Fang-Jie Zhao
Summary: The supply of zinc can greatly enhance the translocation of cadmium from roots to shoots in rice. RNA sequencing showed that high zinc conditions up-regulated the expression of genes involved in glutathione biosynthesis and metabolism, as well as the zinc/cadmium transporter gene OsHMA2. Knockout experiments revealed that OsHMA2 is crucial for the promotional effect of zinc on cadmium translocation.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Moumita Chakraborty, Michal Hershfinkel
Summary: Zinc (Zn2+) plays a critical role in cell proliferation, wound healing, gastrointestinal and reproductive systems, as well as in secretory organs, with vital importance in supporting infant growth in the mammary gland and in breast cancer progression.
Article
Biochemistry & Molecular Biology
Daniel W. Valencia, Ady B. Melendez, Isaac A. Melendrez, Erik T. Yukl
Summary: ATP binding cassette (ABC) transporters are the primary means by which bacteria acquire trace elements from the environment. They rely on solute binding proteins (SBPs) to bind the relevant substrate and deliver it to the integral membrane permease for ATP-powered import into the cytoplasm. A newly discovered family of zinc SBPs, represented by ZrgA proteins, has been found in Gram-negative bacteria, including human pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Anuj Kumar Sharma, Lydia Finney, Stefan Vogt, Olena K. Vatamaniuk, Sungjin Kim
Summary: This study investigates the distribution and effect of cadmium (Cd) on the accumulation and distribution of biologically relevant elements using the model system Caenorhabditis elegans. The results show that Cd exposure leads to internal accumulation and altered ionome in C. elegans. The study also demonstrates that supplementing with zinc can alleviate Cd toxicity and that mutations in zinc transporters increase sensitivity to Cd toxicity. Additionally, the spatial distribution of mineral elements is significantly affected by Cd.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Oncology
Eddie Zhang, Karen J. Ruth, Mark K. Buyyounouski, Robert A. Price Jr, Robert G. Uzzo, Mark L. Sobczak, Alan Pollack, J. . Karen Wong, David Y. T. Chen, Mark A. Hallman, Richard E. Greenberg, Deborah Watkins-Bruner, Tahseen Al-Saleem, Eric M. Horwitz
Summary: This study aimed to compare the preservation of erectile function between limiting the doses delivered to the penile bulb and corporal bodies with intensity modulated radiation therapy (IMRT) and standard IMRT in men with prostate cancer. The results showed that there was no significant difference in the preservation of erectile function between the two treatment methods.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Letter
Oncology
Laura Bukavina, Mohit Sindhani, Shreyas S. Joshi, Elizabeth Plimack, Andres Correa, Nicole Uzzo, Alexander Kutikov, Robert Uzzo
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Antoin Douglawi, Alireza Ghoreifi, Umberto Carbonara, Wesley Yip, Robert G. Uzzo, Vitaly Margulis, Matteo Ferro, Ottavio De Cobelli, Zhenjie Wu, Giuseppe Simone, Riccardo Mastroianni, Koon H. Rha, Daniel D. Eun, Adam C. Reese, James R. Porter, Ithaar Derweesh, Reza Mehrazin, Giuseppe Rosiello, Riccardo Tellini, Marcus Jamil, Alexander Kenigsberg, Jason M. Farrow, William P. Schrock, Giovanni Cacciamani, Abhishek Srivastava, Amit S. Bhattu, Alexandre Mottrie, Mark L. Gonzalgo, Chandru P. Sundaram, Firas Abdollah, Andrea Minervini, Riccardo Autorino, Hooman Djaladat
Summary: This study retrospectively analyzed data of UTUC patients who underwent RNU and found that VH was associated with increased risk of metastasis and death.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Oncology
Laura Bukavina, Spencer Bell, Vignesh T. Packiam, Marc Smaldone, Philip Abbosh, Robert Uzzo, Alexander Kutikov, Andres F. Correa, Diana E. Magee
Summary: This study evaluated the cost effectiveness of BCG compared to sequential gemcitabine-docetaxel in high-risk NMIBC patients. The results showed that gemcitabine-docetaxel had similar effectiveness but lower cost than BCG, making it a potential alternative as a first-line intravesical therapy.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Marshall Strother, Robert N. Uzzo, Elizabeth Handorf, Robert G. Uzzo
Summary: The study aimed to validate the overflowing beer sign (OBS) for distinguishing between lipid-poor angiomyolipoma (AML) and renal cell carcinoma, and to determine whether it improves the detection of lipid-poor AML when added to the angular interface sign. The results showed that both OBS and angular interface sign were strongly associated with AML and had high specificity in the lipid-poor population. Using both signs together increased the sensitivity of AML detection without significantly reducing specificity.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Multidisciplinary Sciences
Nityam Rathi, Worapat Attawettayanon, Yosuke Yasuda, Kieran Lewis, Gustavo Roversi, Snehi Shah, Andrew Wood, Carlos Munoz-Lopez, Diego A. Palacios, Jianbo Li, Nour Abdallah, Jared P. Schober, Marshall Strother, Alexander Kutikov, Robert Uzzo, Christopher J. Weight, Mohamed Eltemamy, Venkatesh Krishnamurthi, Robert Abouassaly, Steven C. Campbell
Summary: Accurate prediction of NBGFR after RN is crucial for clinical management and patient counseling. Preoperative global GFR, SRF, and RFC are important factors for this prediction. In this study, the accuracy of three methods (NRS, software-derived PVA, and LWH measurements) for determining SRF and predicting NBGFR were compared. The results showed that software-derived PVA had the highest accuracy and precision in estimating SRF and predicting NBGFR.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Jared P. Schober, Kevin B. Ginsburg, Alexander Kutikov, Eric Y. Cho, Matt Loecher, David Strauss, Alberto Andres Castro Bigalli, Elizabeth Handorf, Mengying Deng, Jordan Anaokar, David Y. T. Chen, Richard E. Greenberg, Marc C. Smaldone, Rosalia Viterbo, Andres F. Correa, Robert G. Uzzo, Marshall Strother
Summary: This study aimed to evaluate whether a simple point-of-care measurement system could be used to replace nuclear medicine renal scintigraphy (NMRS) in predicting estimated glomerular filtration rate (eGFR) after nephrectomy. The results showed that the point-of-care tool (RENAL-MS) performed equally well as NMRS in predicting postoperative eGFR and de novo Stage 3 chronic kidney disease (CKD), suggesting that NMRS may not be necessary in this setting.
Article
Urology & Nephrology
Deepak K. Pruthi, Gregor Miller, Donna P. Ankerst, Matthias Neumair, Umberto Capitanio, Andres F. Correa, Brian R. Lane, Eduard Roussel, Thomas B. Mcgregor, Ithaar H. Derweesh, Mauricio Cordeiro, Phillip M. Pierorazio, Carlos Calvo, Hai Bi, Sabrina L. Noyes, Margaret Meagher, Alexander Kutikov, Robert G. Uzzo, Hendrik Van Poppel, Alessandro Larcher, Francesco Montorsi, Michael W. Kattan, Dharam Kaushik, Michael A. Liss
Summary: This study aimed to investigate whether clinical risk factors and morphometric features on preoperative imaging can predict pathological upstaging in cT1 renal cell carcinoma patients. Through a retrospective study, we found that increasing preoperative tumor size, increasing age, diabetes, higher BMI, and male sex were associated with pathological upstaging. Additionally, hilar tumors were more likely to be upstaged.
JOURNAL OF UROLOGY
(2023)
Article
Medicine, General & Internal
Christopher W. Ryan, Catherine M. Tangen, Elisabeth Heath, Mark N. Stein, Maxwell Meng, Ajjai S. Alva, Sumanta K. Pal, Igor Puzanov, Joseph Clark, Toni K. Choueiri, Neeraj Agarwal, Robert G. Uzzo, Naomi B. Haas, Timothy W. Synold, Melissa Plets, Ulka N. Vaishampayan, Brian M. Shuch, Ian M. Thompson Jr, Primo N. Lara Jr
Summary: Postoperative administration of everolimus did not show improvement in recurrence-free survival compared to placebo for renal cell carcinoma patients at high risk of recurrence after nephrectomy. These results do not provide support for the adjuvant use of everolimus in the treatment of renal cell carcinoma following surgery.
Meeting Abstract
Urology & Nephrology
Laura Bukavina, Mohit Sindhani, Henkel Valentine, Daniel Ranti, Kirtishri Mishra, Alexander Kutikov, Shilpa Gupta, John Sfakianos, Mahmoud Ghannoum, Mauricio Retuerto, Andres Correa, Robert Uzzo, Philip Abbosh
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Clara Cerrato, Margaret F. Meagher, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert Uzzo, Francesco Porpiglia, Umberto Capitanio, James Porter, Alp T. Beksac, Mimi Nguyen, Savio D. Pandolfo, Kevin Hakimi, Luke Wang, Andrea Minervini, Clayton Lau, Monish Aron, Daniel Eun, Alexandre Mottrie, Carmen Mir, Chandru Sundaram, Alessandro Antonelli, Jihad Kaouk, Ithaar H. Derweesh
JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Clara Cerrato, Devin Patel, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert Uzzo, Francesco Porpiglia, Umberto Capitanio, James Porter, Alp Tuna Beksac, Andrea Minervini, Alessandro Antonelli, Maria Angela Cerruto, Clayton Lau, Akbar Ashrafi, Daniel Eun, Alexandre Mottrie, Carmen Mir, Margaret F. Meagher, Dhruv Puri, Mimi Nguyen, Sohail Dhanji, Franklin Liu, Savio D. Pandolfo, Alexander Kutikov, Francesco Montorsi, Inderbir S. Gill, Chandru Sundaram, Jihad Kaouk, Ithaar H. Derweesh
Summary: This study compares the outcomes of robotic-assisted partial nephrectomy (RAPN) and minimally invasive radical nephrectomy (MIS-RN) for complex renal masses (CRM). The results indicate that RAPN is not associated with increased risk of complications or worsened oncological outcomes compared to MIS-RN, and may be preferred when clinically indicated.
WORLD JOURNAL OF UROLOGY
(2023)
