The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability
出版年份 2014 全文链接
标题
The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability
作者
关键词
Common fragile site, FRA16D, Genomic instability, Tumor suppressor, WWOX, ATM, HIF1
出版物
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 71, Issue 23, Pages 4589-4599
出版商
Springer Nature
发表日期
2014-09-22
DOI
10.1007/s00018-014-1724-y
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation
- (2014) M Abu-Remaileh et al. CELL DEATH AND DIFFERENTIATION
- WW domain-containing oxidoreductase’s role in myriad cancers: Clinical significance and future implications
- (2014) Aliza Gardenswartz et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas
- (2014) Ge Gao et al. GENES CHROMOSOMES & CANCER
- Characterizing WW Domain Interactions of Tumor Suppressor WWOX Reveals Its Association with Multiprotein Networks
- (2014) Mohammad Abu-Odeh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response
- (2014) M. Abu-Odeh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding
- (2013) Brent W Ferguson et al. BMC CANCER
- Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer
- (2013) Lena M. Brueckner et al. CANCER LETTERS
- Common chromosomal fragile siteFRA16Dtumor suppressorWWOXgene expression and metabolic reprograming in cells
- (2013) Sonia Dayan et al. GENES CHROMOSOMES & CANCER
- Common chromosome fragile sites in human and murine epithelial cells andFHIT/FRA3Bloss-induced global genome instability
- (2013) Seyed Ali Hosseini et al. GENES CHROMOSOMES & CANCER
- ATM kinase activity modulates ITCH E3-ubiquitin ligase activity
- (2013) S Santini et al. ONCOGENE
- Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion
- (2013) Satoshi Miuma et al. PLoS One
- Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair
- (2013) L. Wan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy
- (2013) Z Salah et al. Cell Death & Disease
- Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes
- (2013) Benoît Le Tallec et al. Cell Reports
- Regulation of EMT by TGFβ in cancer
- (2012) Carl-Henrik Heldin et al. FEBS LETTERS
- Conditional inactivation of the mouseWwoxtumor suppressor gene recapitulates the null phenotype
- (2012) Suhaib K. Abdeen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Characterization of WWOX inactivation in murine mammary gland development
- (2012) Suhaib K. Abdeen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Biophysical Basis of the Binding of WWOX Tumor Suppressor to WBP1 and WBP2 Adaptors
- (2012) Caleb B. McDonald et al. JOURNAL OF MOLECULAR BIOLOGY
- Conditional Wwox Deletion in Mouse Mammary Gland by Means of Two Cre Recombinase Approaches
- (2012) Brent W. Ferguson et al. PLoS One
- Induction of epithelial–mesenchymal transition by transforming growth factor β
- (2012) Aristidis Moustakas et al. SEMINARS IN CANCER BIOLOGY
- The complex basis underlying common fragile site instability in cancer
- (2012) Efrat Ozeri-Galai et al. TRENDS IN GENETICS
- Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression
- (2012) Joshua C. Saldivar et al. PLoS Genetics
- Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
- (2011) Sophia Y. Lunt et al. Annual Review of Cell and Developmental Biology
- Splicing Factor hnRNP A2/B1 Regulates Tumor Suppressor Gene Splicing and Is an Oncogenic Driver in Glioblastoma
- (2011) R. Golan-Gerstl et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3β
- (2011) H-Y Wang et al. CELL DEATH AND DIFFERENTIATION
- WW domain-containing proteins: Retrospectives and the future
- (2011) Zaidoun Salah Frontiers in Bioscience-Landmark
- Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress
- (2011) Aygül Dereli-Öz et al. Molecular Oncology
- Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site
- (2011) Anne Letessier et al. NATURE
- Molecular profiling of common fragile sites in human fibroblasts
- (2011) Benoî Le Tallec et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Wwox inactivation enhances mammary tumorigenesis
- (2011) S K Abdeen et al. ONCOGENE
- Common fragile sites: mechanisms of instability revisited
- (2011) Michelle Debatisse et al. TRENDS IN GENETICS
- The tumor suppressor gene WWOX links the canonical and noncanonical NF- B pathways in HTLV-I Tax-mediated tumorigenesis
- (2010) J. Fu et al. BLOOD
- Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression
- (2010) K. C. Kurek et al. CANCER RESEARCH
- WWOXgene and gene product: tumor suppression through specific protein interactions
- (2010) Zaidoun Salah et al. Future Oncology
- Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species
- (2010) L. V. O'Keefe et al. HUMAN MOLECULAR GENETICS
- Haplo-insufficiency: a driving force in cancer
- (2010) Alice H Berger et al. JOURNAL OF PATHOLOGY
- Signatures of mutation and selection in the cancer genome
- (2010) Graham R. Bignell et al. NATURE
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Genomic instability — an evolving hallmark of cancer
- (2010) Simona Negrini et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma
- (2009) Jilong Yang et al. CANCER LETTERS
- WWOX Gene Expression Abolishes Ovarian Cancer Tumorigenicity In vivo and Decreases Attachment to Fibronectin via Integrin 3
- (2009) C. Gourley et al. CANCER RESEARCH
- WWOX: Its genomics, partners, and functions
- (2009) Sara Del Mare et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Inhibition of the Wnt/β-catenin pathway by the WWOX tumor suppressor protein
- (2009) N Bouteille et al. ONCOGENE
- Generation and Characterization of Mice Carrying a Conditional Allele of the Wwox Tumor Suppressor Gene
- (2009) John H. Ludes-Meyers et al. PLoS One
- Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells
- (2008) Shunji Nakayama et al. CANCER SCIENCE
- Targeted Ablation of the WW Domain-Containing Oxidoreductase Tumor Suppressor Leads to Impaired Steroidogenesis
- (2008) Rami I. Aqeilan et al. ENDOCRINOLOGY
- The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism
- (2008) Rami I. Aqeilan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Oncogene-Induced DNA Damage Model for Cancer Development
- (2008) T. D. Halazonetis et al. SCIENCE
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