Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation

WW domain-containing oxidoreductase’s role in myriad cancers: Clinical significance and future implications

(2014) Aliza Gardenswartz et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Characterizing WW Domain Interactions of Tumor Suppressor WWOX Reveals Its Association with Multiprotein Networks

(2014) Mohammad Abu-Odeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common chromosomal fragile siteFRA16Dtumor suppressorWWOXgene expression and metabolic reprograming in cells

(2013) Sonia Dayan et al.   GENES CHROMOSOMES & CANCER

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy

(2013) Z Salah et al.   Cell Death & Disease

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Digoxin Inhibits Blood Vessel Density and HIF-1a Expression in Castration-Resistant C4-2 Xenograft Prostate Tumors

(2012) Bishoy A. Gayed et al.   CTS-Clinical and Translational Science

Hypoxia in the Eye: A Two-Sided Coin

(2012) Christian Grimm et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling

(2012) F. K. Pientka et al.   JOURNAL OF CELL SCIENCE

Conditional inactivation of the mouseWwoxtumor suppressor gene recapitulates the null phenotype

(2012) Suhaib K. Abdeen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-  signaling

(2012) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wwox inactivation enhances mammary tumorigenesis

(2011) S K Abdeen et al.   ONCOGENE

MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis

(2010) Shih-Ting Cha et al.   CANCER RESEARCH

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

(2010) M-P Puisségur et al.   CELL DEATH AND DIFFERENTIATION

Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization

(2010) Tsunehiko Yoshida et al.   FASEB JOURNAL

WWOXgene and gene product: tumor suppression through specific protein interactions

(2010) Zaidoun Salah et al.   Future Oncology

Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species

(2010) L. V. O'Keefe et al.   HUMAN MOLECULAR GENETICS

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

WWOX: Its genomics, partners, and functions

(2009) Sara Del Mare et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Generation and Characterization of Mice Carrying a Conditional Allele of the Wwox Tumor Suppressor Gene

(2009) John H. Ludes-Meyers et al.   PLoS One

Identification of Hypoxia-Inducible Factor-1  as a Novel Target for miR-17-92 MicroRNA Cluster

(2008) A. Taguchi et al.   CANCER RESEARCH

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Role and regulation of prolyl hydroxylase domain proteins

(2008) G-H Fong et al.   CELL DEATH AND DIFFERENTIATION

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism

(2008) Rami I. Aqeilan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA