Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics
出版年份 2012 全文链接
标题
Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics
作者
关键词
-
出版物
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 69, Issue 12, Pages 1967-1995
出版商
Springer Nature
发表日期
2012-01-28
DOI
10.1007/s00018-011-0906-0
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Anti-malarial drug formulations and novel delivery systems: A review
- (2011) P. Murambiwa et al. ACTA TROPICA
- In VivoandIn VitroAntimalarial Properties of Azithromycin-Chloroquine Combinations That Include the Resistance Reversal Agent Amlodipine
- (2011) Marcus R. Pereira et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- 4-Aminoquinolines Active against Chloroquine-Resistant Plasmodium falciparum: Basis of Antiparasite Activity and Quantitative Structure-Activity Relationship Analyses
- (2011) Simon J. Hocart et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-PressuredPlasmodium falciparumParasites
- (2011) Richard T. Eastman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Phenotypic and Genotypic Analysis ofIn Vitro-Selected Artemisinin-Resistant Progeny of Plasmodium falciparum
- (2011) Matthew S. Tucker et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Pharmacokinetics, Pharmacodynamics, and Allometric Scaling of Chloroquine in a Murine Malaria Model
- (2011) Brioni R. Moore et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The State of the Art in Anti-Malarial Drug Discovery and Development
- (2011) Jeremy N. Burrows et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT
- (2011) Vincent K. Zishiri et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy
- (2011) R Matthew Chico et al. Expert Opinion on Drug Metabolism & Toxicology
- Drug-resistant malaria: Molecular mechanisms and implications for public health
- (2011) Ines Petersen et al. FEBS LETTERS
- Quinoline Antimalarials Containing a Dibemethin Group Are Active against Chloroquinone-ResistantPlasmodium falciparumand Inhibit Chloroquine Transport via theP. falciparumChloroquine-Resistance Transporter (PfCRT)
- (2011) Vincent K. Zishiri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type
- (2011) Juliana M Sa et al. MALARIA JOURNAL
- Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan
- (2011) Natasha Howard et al. MALARIA JOURNAL
- Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
- (2011) Jane Achan et al. MALARIA JOURNAL
- Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum
- (2011) Wanna Chaijaroenkul et al. MALARIA JOURNAL
- Polymorphism of Plasmodium falciparum Na+/H+ exchanger is indicative of a low in vitro quinine susceptibility in isolates from Viet Nam
- (2011) Véronique Sinou et al. MALARIA JOURNAL
- Phase I randomized dose-ascending placebo-controlled trials of ferroquine - a candidate anti-malarial drug - in adults with asymptomatic Plasmodium falciparum infection
- (2011) Ghyslain Mombo-Ngoma et al. MALARIA JOURNAL
- Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria
- (2011) Carrie A Morris et al. MALARIA JOURNAL
- In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo
- (2011) Sébastien Briolant et al. MALARIA JOURNAL
- Novel Polymorphisms in Plasmodium falciparum ABC Transporter Genes Are Associated with Major ACT Antimalarial Drug Resistance
- (2011) Maria Isabel Veiga et al. PLoS One
- Artesunate Dose Escalation for the Treatment of Uncomplicated Malaria in a Region of Reported Artemisinin Resistance: A Randomized Clinical Trial
- (2011) Delia Bethell et al. PLoS One
- Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets
- (2011) J. Yuan et al. SCIENCE
- The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance
- (2010) Faustine Dubar et al. ACS Chemical Biology
- Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso
- (2010) Ina Danquah et al. ACTA TROPICA
- Association of Microsatellite Variations of Plasmodium falciparum Na+/H+ Exchanger (Pfnhe-1) Gene with Reduced In Vitro Susceptibility to Quinine: Lack of Confirmation in Clinical Isolates from Africa
- (2010) Valérie Andriantsoanirina et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- In Vitro Sensitivity of Plasmodium falciparum Clinical Isolates from the China-Myanmar Border Area to Quinine and Association with Polymorphism in the Na+/H+ Exchanger
- (2010) H. Meng et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Role of pfmdr1 Amplification and Expression in Induction of Resistance to Artemisinin Derivatives in Plasmodium falciparum
- (2010) M. Chavchich et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Absence of Association between Piperaquine In Vitro Responses and Polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe Genes in Plasmodium falciparum
- (2010) S. Briolant et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria Parasites
- (2010) Dorothee Beez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Activity of Pyronaridine against Multidrug-Resistant Plasmodium falciparum and Plasmodium vivax
- (2010) R. N. Price et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya
- (2010) J. Okombo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Limited Ability ofPlasmodium falciparum pfcrt,pfmdr1, andpfnhe1Polymorphisms To Predict QuinineIn VitroSensitivity or Clinical Effectiveness in Uganda
- (2010) Frederick N. Baliraine et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Sensitivities of Plasmodium falciparum to Different Antimalarial Drugs in Uganda
- (2010) S. L. Nsobya et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Synthesis of new 4-aminoquinolines and quinoline–acridine hybrids as antimalarial agents
- (2010) Ashok Kumar et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Artemisinin Resistance in Cambodia: A Clinical Trial Designed to Address an Emerging Problem in Southeast Asia
- (2010) Harald Noedl et al. CLINICAL INFECTIOUS DISEASES
- Dose‐Dependent Risk of Neutropenia after 7‐Day Courses of Artesunate Monotherapy in Cambodian Patients with AcutePlasmodium falciparumMalaria
- (2010) Delia Bethell et al. CLINICAL INFECTIOUS DISEASES
- Transporters as mediators of drug resistance in Plasmodium falciparum
- (2010) Cecilia P. Sanchez et al. INTERNATIONAL JOURNAL FOR PARASITOLOGY
- Is Chloroquine Making a Comeback?
- (2010) Carla Cerami Hand et al. JOURNAL OF INFECTIOUS DISEASES
- Similar Efficacy and Tolerability of Double-Dose Chloroquine and Artemether-Lumefantrine for Treatment of Plasmodium falciparum Infection in Guinea-Bissau: A Randomized Trial
- (2010) Johan Ursing et al. JOURNAL OF INFECTIOUS DISEASES
- Development of a New Generation of 4-Aminoquinoline Antimalarial Compounds Using Predictive Pharmacokinetic and Toxicology Models
- (2010) Sunetra Ray et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, Structure−Activity Relationship, and Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds
- (2010) Steven J. Burgess et al. JOURNAL OF MEDICINAL CHEMISTRY
- Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria
- (2010) Bryan K. S. Yeung et al. JOURNAL OF MEDICINAL CHEMISTRY
- Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene
- (2010) Bianca E Gama et al. MALARIA JOURNAL
- Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai-Myanmar border
- (2010) Kesara Na-Bangchang et al. MALARIA JOURNAL
- Absence of association between pyronaridine in vitro responses and polymorphisms in genes involved in quinoline resistance in Plasmodium falciparum
- (2010) Bruno Pradines et al. MALARIA JOURNAL
- Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols
- (2010) Erin Milner et al. MALARIA JOURNAL
- Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross
- (2010) Jigar J. Patel et al. MOLECULAR MICROBIOLOGY
- Thousands of chemical starting points for antimalarial lead identification
- (2010) Francisco-Javier Gamo et al. NATURE
- Chemical genetics of Plasmodium falciparum
- (2010) W. Armand Guiguemde et al. NATURE
- Priming the antimalarial pipeline
- (2010) David A. Fidock NATURE
- Is the Tide Turning for New Malaria Medicines?
- (2010) T. N. C. Wells SCIENCE
- Malaria's Drug Miracle in Danger
- (2010) M. Enserink SCIENCE
- Spiroindolones, a Potent Compound Class for the Treatment of Malaria
- (2010) M. Rottmann et al. SCIENCE
- Functional characteristics of the malaria parasite's "chloroquine resistance transporter": Implications for chemotherapy
- (2010) Robert L. Summers et al. Virulence
- Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum
- (2010) Stephanie G. Valderramos et al. PLoS Pathogens
- Chloroquine Resistance: Proposed Mechanisms and Countermeasures
- (2010) Eric Guantai et al. Current Drug Delivery
- Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate
- (2009) Wanna Chaijaroenkul et al. ACTA TROPICA
- Plasmodium falciparum Na+/H+ Exchanger 1 Transporter Is Involved in Reduced Susceptibility to Quinine
- (2009) M. Henry et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Role of Known Molecular Markers of Resistance in the Antimalarial Potency of Piperaquine and Dihydroartemisinin In Vitro
- (2009) S. Muangnoicharoen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Disruption of aPlasmodium falciparumMultidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione
- (2009) Dipak Kumar Raj et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Candidate Selection and Preclinical Evaluation ofN-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century
- (2009) Paul M. O’Neill et al. JOURNAL OF MEDICINAL CHEMISTRY
- A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria
- (2009) Stéphane Picot et al. MALARIA JOURNAL
- Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia
- (2009) William O Rogers et al. MALARIA JOURNAL
- Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE
- (2009) Louis J. Nkrumah et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Discovery of dual function acridones as a new antimalarial chemotype
- (2009) Jane X. Kelly et al. NATURE
- New medicines to improve control and contribute to the eradication of malaria
- (2009) Timothy N. C. Wells et al. NATURE REVIEWS DRUG DISCOVERY
- Artemisinin Resistance inPlasmodium falciparumMalaria
- (2009) Arjen M. Dondorp et al. NEW ENGLAND JOURNAL OF MEDICINE
- Association of molecular markers in Plasmodium falciparum crt and mdr1 with in vitro chloroquine resistance: A Philippine study
- (2009) Toshimitsu Hatabu et al. PARASITOLOGY INTERNATIONAL
- Changes in the Treatment Responses to Artesunate-Mefloquine on the Northwestern Border of Thailand during 13 Years of Continuous Deployment
- (2009) Verena Ilona Carrara et al. PLoS One
- Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine
- (2009) Juliana Martha Sá et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter
- (2009) R. E. Martin et al. SCIENCE
- Trafficking of the Phosphoprotein PfCRT to the Digestive Vacuolar Membrane inPlasmodium falciparum
- (2009) Yvonne Kuhn et al. TRAFFIC
- Chloroquine Resistance-Conferring Mutations in pfcrt Give Rise to a Chloroquine-Associated H+ Leak from the Malaria Parasite's Digestive Vacuole
- (2008) A. M. Lehane et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Chloroquine Is Grossly Overdosed and Overused but Well Tolerated in Guinea-Bissau
- (2008) J. Ursing et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Discordant Patterns of Genetic Variation at Two Chloroquine Resistance Loci in Worldwide Populations of the Malaria Parasite Plasmodium falciparum
- (2008) R. K. Mehlotra et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Reversed Chloroquines Based on the 3,4-Dihydropyrimidin-2(1H)-one Scaffold: Synthesis and Evaluation for Antimalarial, β-Haematin Inhibition, and Cytotoxic Activity
- (2008) Natasha October et al. ChemMedChem
- A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites
- (2008) A. M. Lehane et al. JOURNAL OF CELL SCIENCE
- The crystal structure of halofantrine–ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials
- (2008) Katherine A. de Villiers et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment
- (2008) TO Ogungbamigbe et al. MEMORIAS DO INSTITUTO OSWALDO CRUZ
- Malaria Combination Therapies: Advantages and Shortcomings
- (2008) A. Martinelli et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Acid extrusion from the intraerythrocytic malaria parasite is not via a Na+/H+ exchanger
- (2008) Natalie J. Spillman et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Dissecting the components of quinine accumulation in Plasmodium falciparum
- (2008) Cecilia P. Sanchez et al. MOLECULAR MICROBIOLOGY
- A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes
- (2008) Iñigo Angulo-Barturen et al. PLoS One
- Selection of a trioxaquine as an antimalarial drug candidate
- (2008) F. Cosledan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
- (2008) David Plouffe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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