Article
Pharmacology & Pharmacy
Yuxi Zhang, Yi Wang, Yanping Li, Cong Huang, Xiaoqian Xiao, Zhanqiong Zhong, Jingyi Tang, Haolan Lu, Yibei Tang, Jiahui Yang
Summary: In this study, it is shown that dihydroartemisinin (DHA) and artemisinin (AS) inhibit aerobic glycolysis in non-small cell lung cancer (NSCLC) cells through the ERK/c-Myc pathway, leading to the inhibition of tumor growth. This study expands our knowledge of artemisinin derivatives in regulating tumor glucose metabolism and provides a potential strategy for lung cancer therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Emma Hughes, Erika Wallender, Richard Kajubi, Prasanna Jagannathan, Teddy Ochieng, Abel Kakuru, Moses R. Kamya, Tamara D. Clark, Philip J. Rosenthal, Grant Dorsey, Francesca Aweeka, Radojka M. Savic
Summary: This study found that repeated use of DHA-PQ does not increase the risk of QTc prolongation, and the QTc intervals decrease progressively after drug administration.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Eliford Kitabi, Timothy J. Bensman, Justin C. Earp, Dakshina M. Chilukuri, Heidi Smith, Leslie Ball, Elizabeth O'Shaughnessy, Yuliya Yasinskaya, Philip M. Colangelo, Kellie S. Reynolds
Summary: The World Health Organization recommends 3 mg/kg intravenous artesunate for pediatric patients weighing less than 20 kg for severe malaria treatment. The Food and Drug Administration, however, chose 2.4 mg/kg based on literature review and independent analyses for the same patient population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Clifford G. Banda, Dumisile Nkosi, Elizabeth Allen, Lesley Workman, Mwayiwawo Madanitsa, Marumbo Chirwa, Mayamiko Kapulula, Sharon Muyaya, Steven Munharo, Joel Tarning, Kamija S. Phiri, Victor Mwapasa, Feiko O. ter Kuile, Gary Maartens, Karen I. Barnes
Summary: In pregnant women living with HIV, the use of efavirenz-based antiretroviral therapy significantly reduces the plasma exposure of piperaquine. However, coadministration of dihydroartemisinin-piperaquine and dolutegravir-based ART can increase the overall piperaquine exposure without affecting its maximum concentration. This finding suggests that the efficacy of dihydroartemisinin-piperaquine will be retained in pregnant women on dolutegravir.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Woo-Yul Lee, Dong-Woo Chae, Choon-Ok Kim, Sang-Eun Lee, Yee-Gyung Kwak, Joon-Sup Yeom, Kyung-Soo Park
Summary: The study aimed to develop a population pharmacokinetic model of primaquine and its metabolite, and found that body weight and CYP2D6 activity significantly impact primaquine pharmacokinetics. The results showed that weight and enzyme activity play crucial roles in drug metabolism and can influence drug exposure levels.
Article
Medicine, General & Internal
Humera Qureshi, Muhammad Imran Khan, Akhlaq Ahmad, Usman Ayub Awan, Aamer Ali Khattak, Ayesha Ali Khan, Yaqiong Sun
Summary: This study found high prevalence of malaria in non-pregnant women, with Plasmodium vivax infection being more common. Chloroquine and primaquine were the most commonly used medications to treat malaria. Strengthening malaria surveillance and eradication programs is essential in this endemic region with limited healthcare facilities.
FRONTIERS IN MEDICINE
(2021)
Article
Parasitology
Wenju Guo, Ning Li, Guolian Ren, RongRong Wang, Liqing Chai, Yujie Li, Xi Wang, Qingshan Yang, Ruili Wang, Guoshun Zhang, Liuqing Yang, Bofang Yi, Shuqiu Zhang
Summary: The newly synthesized drug DHA(3)NPs exhibited promising pharmacokinetic characteristics and antimalarial pharmacodynamics in vivo, demonstrating good therapeutic potential in the treatment of malaria.
PARASITOLOGY RESEARCH
(2021)
Article
Microbiology
Ahizechukwu C. Eke, Kensuke Shoji, Brookie M. Best, Jeremiah D. Momper, Alice M. Stek, Tim R. Cressey, Mark Mirochnick, Edmund Capparelli
Summary: The pharmacokinetics of tenofovir in pregnant and postpartum women were affected by changes in apparent oral clearance and volume of distribution at steady state. These changes were primarily associated with increased body weight and enhanced renal function during pregnancy, leading to higher clearance rates compared to postpartum values. Dose adjustment of tenofovir disoproxil fumarate during pregnancy is generally not necessary, but any modifications should be made based on considerations of weight and renal function.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Mateusz M. Plucinski, Joel L. N. Barratt
Summary: This study introduces a novel method for nonparametric statistical testing of relatedness for P. falciparum parasites. The approach showed high sensitivity and reliability in identifying related genotypes.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Microbiology
Ali Mohamed Ali, Kamunkhwala Gausi, Said A. Jongo, Kamaka R. Kassim, Catherine Mkindi, Beatus Simon, Ali T. Mtoro, Omar A. Juma, Omar N. Lweno, Conrad H. Gwandu, Bakari M. Bakari, Thabiti A. Mbaga, Florence A. Milando, Ali Hamad, Seif A. Shekalaghe, Salim Abdulla, Paolo Denti, Melissa A. Penny
Summary: This study characterized the pharmacokinetics of ART-NQ in adults and children, providing valuable information for determining drug concentrations in patients during treatment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Wei Wei, Weijia Cheng, Wenhao Dai, Feng Lu, Yaru Cheng, Tingting Jiang, Zhenyu Ren, Yiting Xie, Jiahui Xu, Qun Zhao, Xianjun Yu, Yi Yin, Jian Li, Haifeng Dong
Summary: This study introduces a nanoparticle formulation of an antimalarial drug coated in a biomimetic membrane derived from brain microvascular endothelial cells and demonstrates its therapeutic efficacy in a mouse model of cerebral malaria, offering new insight into nanoparticle-based therapeutics for malaria and parasitic infections.
Review
Pharmacology & Pharmacy
Qi Jin, Tongtong Liu, Danqian Chen, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Ping Li, Yongli Zhan
Summary: Artemisinin and its derivatives have been found to be effective in treating diseases such as malaria, cancer, immune disorders, and inflammatory diseases, with fewer side effects. They also possess antioxidant and anti-inflammatory properties, regulate immune system and autophagy, and modulate glycolipid metabolism, suggesting their potential in managing kidney diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Alfred Kwizera, Diomede Ntasumumuyange, Maria Small, Stephen Rulisa, Alexandra N. Moscovitz, Urania Magriples
Summary: Malaria in pregnancy is associated with adverse perinatal outcomes. A prospective cohort study in Rwanda found that the occurrence of severe malaria increased as pregnancy progressed, resulting in poorer perinatal outcomes. Significant differences in perinatal outcomes were observed based on the trimester of pregnancy and severity of malaria infection.
Article
Infectious Diseases
Anna Munsey, Alen Kinyina, Melkior Assenga, Annette Almeida, Chonge Kitojo, Erik Reaves, Japhet Simeo, Sijenunu Aron, Frank Chacky, Samwel L. Nhiga, Mary Drake, Ruth Lemwayi, Ryan Lash, Patrick G. T. Walker, Julie R. Gutman
Summary: Data collected during antenatal care (ANC) can effectively track trends in malaria burden. However, further research is needed to elucidate the value of administering questionnaires to ANC attendees.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
J. W. Bezuidenhout, M. Aucamp, N. Stieger, W. Liebenberg, R. K. Haynes
Summary: To establish the best processing parameters and storage conditions for nanolipid formulations of artesunate, the thermal stability and solubility profiles of artesunate in aqueous solutions were evaluated at different temperatures and pH levels. The study found that artesunate remained relatively stable at temperatures up to 40°C and 75% relative humidity for 3 months, with approximately 9% decomposition. However, higher temperatures led to significantly greater decomposition and the formation of dihydroartemisinin (DHA) and other products. The solubility of artesunate varied with pH, with the highest solubility observed at pH 6.8 (phosphate buffer). Overall, maintaining relatively low temperatures is crucial for the preparation and storage of artesunate formulations.
Article
Immunology
Diana Huis in 't Veld, Eric Balestre, Jozefien Buyze, Joris Menten, Antoine Jaquet, David A. Cooper, Francois Dabis, Constantin T. Yiannoutsos, Lameck Diero, Portia Mutevedzi, Matthew P. Fox, Eugene Messou, Christopher J. Hoffmann, Hans W. Prozesky, Matthias Egger, Jennifer J. Hemingway-Foday, Robert Colebunders
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2015)
Article
Medicine, General & Internal
Fernando Althabe, Jose M. Belizan, Elizabeth M. McClure, Jennifer Hemingway-Foday, Mabel Berrueta, Agustina Mazzoni, Alvaro Ciganda, Shivaprasad S. Goudar, Bhalachandra S. Kodkany, Niranjana S. Mahantshetti, Sangappa M. Dhaded, Geetanjali M. Katageri, Mrityunjay C. Metgud, Anjali M. Joshi, Mrutyunjaya B. Bellad, Narayan V. Honnungar, Richard J. Derman, Sarah Saleem, Omrana Pasha, Sumera Ali, Farid Hasnain, Robert L. Goldenberg, Fabian Esamai, Paul Nyongesa, Silas Ayunga, Edward A. Liechty, Ana L. Garces, Lester Figueroa, K. Michael Hambidge, Nancy F. Krebs, Archana Patel, Anjali Bhandarkar, Manjushri Waikar, Patricia L. Hibberd, Elwyn Chomba, Waldemar A. Carlo, Angel Mwiche, Melody Chiwila, Albert Manasyan, Sayury Pineda, Sreelatha Meleth, Vanessa Thorsten, Kristen Stolka, Dennis D. Wallace, Marion Koso-Thomas, Alan H. Jobe, Pierre M. Buekens
Article
Public, Environmental & Occupational Health
Mabel Berrueta, Jennifer Hemingway-Foday, Vanessa R. Thorsten, Robert L. Goldenberg, Waldemar A. Carlo, Ana Garces, Archana Patel, Sarah Saleem, Omrana Pasha, Elwyn Chomba, Patricia L. Hibberd, Nancy F. Krebs, Shivaprasad Goudar, Richard J. Derman, Fabian Esamai, Edward A. Liechty, Janet L. Moore, Elizabeth M. McClure, Marion Koso-Thomas, Pierre M. Buekens, Jose M. Belizan, Fernando Althabe
REPRODUCTIVE HEALTH
(2016)
Article
Obstetrics & Gynecology
Matthew K. Hoffman, Shivaprasad S. Goudar, Bhalachandra S. Kodkany, Norman Goco, Marion Koso-Thomas, Menachem Miodovnik, Elizabeth M. McClure, Dennis D. Wallace, Jennifer J. Hemingway-Foday, Antoinette Tshefu, Adrien Lokangaka, Carl L. Bose, Elwyn Chomba, Musaku Mwenechanya, Waldemar A. Carlo, Ana Garces, Nancy F. Krebs, K. Michael Hambidge, Sarah Saleem, Robert L. Goldenberg, Archana Patel, Patricia L. Hibberd, Fabian Esamai, Edward A. Liechty, Robert Silver, Richard J. Derman
BMC PREGNANCY AND CHILDBIRTH
(2017)
Article
Genetics & Heredity
Elena M. Cornejo Castro, Brian J. Morrison, Vickie A. Marshall, Nazzarena Labo, Wendell J. Miley, Nathan Clements, George Nelson, Paul Ndom, Kristen Stolka, Jennifer J. Hemingway-Foday, Mahamat Abassora, Xiaojiang Gao, Jennifer S. Smith, Mary Carrington, Denise Whitby
GENES AND IMMUNITY
(2019)
Article
Oncology
Nazzarena Labo, Vickie Marshall, Wendell Miley, Eliza Davis, Brendan McCann, Kristen B. Stolka, Paul Ndom, Jennifer J. Hemingway-Foday, Mahamat Abassora, Robert Newton, Jennifer S. Smith, Denise Whitby
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Public, Environmental & Occupational Health
Kathryn E. L. Grimes, Bonaventure Fuamba Ngoyi, Kristen B. Stolka, Jennifer J. Hemingway-Foday, Leopold Lubula, Mathias Mossoko, Antoine Okitandjate, Pia D. M. MacDonald, Amy Nelson, Sarah Rhea, Benoit Kebela Ilunga
FRONTIERS IN PUBLIC HEALTH
(2020)
Article
Public, Environmental & Occupational Health
Jennifer J. Hemingway-Foday, Bonaventure Fuamba Ngoyi, Christian Tunda, Kristen B. Stolka, Kathryn E. L. Grimes, Leopold Lubula, Mathias Mossoko, Benoit Ilunga Kebela, Linda M. Brown, Pia D. M. MacDonald
Article
Public, Environmental & Occupational Health
Claire J. Standley, Pia D. M. MacDonald, Aurelia Attal-Juncqua, Alpha Mahmoud Barry, Ebi Celestin Bile, Doreen L. Collins, Salomon Corvil, Diallo Boubabar Ibrahima, Jennifer J. Hemingway-Foday, Rebecca Katz, Kathy J. Middleton, Eileen M. Reynolds, Erin M. Sorrell, Soumah Mohamed Lamine, Abdoulaye Wone, Lise D. Martel
Article
Medicine, General & Internal
Matthew K. Hoffman, Shivaprasad S. Goudar, Bhalachandra S. Kodkany, Mrityunjay Metgud, Manjunath Somannavar, Jean Okitawutshu, Adrien Lokangaka, Antoinette Tshefu, Carl L. Bose, Abigail Mwapule, Musaku Mwenechanya, Elwyn Chomba, Waldemar A. Carlo, Javier Chicuy, Lester Figueroa, Ana Garces, Nancy F. Krebs, Saleem Jessani, Farnaz Zehra, Sarah Saleem, Robert L. Goldenberg, Kunal Kurhe, Prabir Das, Archana Patel, Patricia L. Hibberd, Emmah Achieng, Paul Nyongesa, Fabian Esamai, Edward A. Liechty, Norman Goco, Jennifer Hemingway-Foday, Janet Moore, Tracy L. Nolen, Elizabeth M. McClure, Marion Koso-Thomas, Menachem Miodovnik, R. Silver, Richard J. Derman
Article
Health Policy & Services
Tiffany L. Breger, Jamie E. Newman, Brigitte Mfangam Molu, Wilfred Akam, Ashu Balimba, Joseph Atibu, Modeste Kiumbu, Innocent Azinyue, Jennifer Hemingway-Foday, Brian W. Pence
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2017)
Article
Health Policy & Services
Sue Napierala Mavedzenge, Jamie E. Newman, Martin Nduwimana, Helene Bukuru, Pierre Kariyo, Theodore Niyongabo, Marcel Mbaya, Henri Mukumbi, Nelly Kamgaing, Marie-Therese Obama, Wilfred Akam, Joseph Atibu, Modeste Kiumbu, J. Hemingway-Foday
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2017)
Article
Social Work
Jamie Newman, Nelly Kamgaing, Martin Nduwimana, Marie-Therese Obama, Helene Bukuru, Pierre Kariyo, Theodore Niyongabo, Marc Mbaya, Henri Mukumbi, Wilfred Akam, Jeniffer Iriondo-Perez, Joseph Atibu, Modeste Kiumbu, Innocent Azinyue, Jennifer Hemingway-Foday
JOURNAL OF HIV-AIDS & SOCIAL SERVICES
(2016)
Article
Public, Environmental & Occupational Health
Kristen B. Stolka, Bonaventure Fuamba Ngoyi, Kathyrn E. L. Grimes, Jennifer J. Hemingway-Foday, Leopold Lubula, Alain Nzanzu Magazani, Joseph Bikuku, Mathias Mossoko, Leonie Manya Kitoto, Sylvie Mpangi Bashilebo, Dieudonne Lufwa Maya, Benoit Kebela Ilunga, Sarah Rhea, Pia D. M. MacDonald
Article
Health Policy & Services
Kristen Stolka, Jeniffer Iriondo-Perez, Modeste Kiumbu, Joseph Atibu, Innocent Azinyue, Wilfred Akam, Ashue Balimba, Brigitte Mfangam Molu, Henri Mukumbi, Theodore Niyongabo, Christelle Twizere, Jamie Newman, Jennifer Hemingway-Foday
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2016)