Review
Medicine, General & Internal
Marcelo B. Zani, Aquiles M. Sant'Ana, Rafael C. Tognato, Jair R. Chagas, Luciano Puzer
Summary: Human tissue Kallikrein-related peptidases (hKLKs) play important roles in skin desquamation and skin diseases by cleaving corneodesmosomes and activating the PAR2 pathway. Inhibition of hKLKs shows promise as a therapeutic approach for improving the quality of life in patients with skin diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Genetics & Heredity
Xuan Wang, Jun Liu, Junyi Chen, Xueyan Xu, Yadan Zhong, Yingping Xu, Ping Lu, Jiajian Zhou, Zhimiao Lin, Bin Yang, Chao Yang
Summary: Loss-of-function mutation in CST6 gene causes dry skin, desquamation, and abnormal keratosis.
Review
Oncology
Georgia Sotiropoulou, Eleni Zingkou, Georgios Pampalakis
Summary: This article discusses the regulatory mechanisms of epidermal proteolysis and its importance in skin physiology and disease states. Recent studies have revealed the complexity of epidermal proteolytic and signaling pathways, as well as their association with lipid metabolism.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Bhavneet Bhinder, Alison Ferguson, Michael Sigouros, Manik Uppal, Ahmed G. Elsaeed, Rohan Bareja, Hussein Alnajar, Kenneth Wha Eng, Vincenza Conteduca, Andrea Sboner, Juan Miguel Mosquera, Olivier Elemento, Himisha Beltran
Summary: This study analyzed the RNA-sequencing and whole-exome sequencing data of 170 patients with neuroendocrine prostate cancer (NEPC). It found that NEPC has a unique tumor immune landscape compared to other prostate cancer types and small-cell lung cancer (SCLC). NEPC is characterized by a relatively immune-depleted tumor immune microenvironment and less mutations, but has comparable expression of checkpoint genes PD-L1 and CTLA-4 with SCLC. These findings can inform the development of immunotherapy strategies for NEPC.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Domien Vanneste, Jens Staal, Mira Haegman, Yasmine Driege, Marieke Carels, Elien Van Nuffel, Pieter De Bleser, Yvan Saeys, Rudi Beyaert, Inna S. Afonina
Summary: Prostate cancer is one of the most common cancer types in men, and its increasing prevalence worldwide is attributed to the influence of modern Western lifestyle. Through analysis of cancer databases, it has been found that overexpression of CARD14 is strongly associated with aggressive prostate cancer in human patients. Furthermore, it has been demonstrated that CARD14-induced signaling plays a role in regulating prostate cancer cell survival and gene expression.
Correction
Chemistry, Physical
Giovanna Tomaiuolo, Fiammetta Fellico, Valentina Preziosi, Federica Cariati, Ida Strina, Carmela Votino, Fulvio Zullo, Salvatore Longobardi, Stefano Guido
Summary: The article 'Post-liquefaction normospermic human semen behaves as a weak-gel viscoelastic fluid' by Giovanna Tomaiuolo et al. demonstrates experimentally that post-liquefaction normospermic human semen behaves as a weak-gel viscoelastic fluid. This finding is important for studying sperm motility and reproductive health.
Review
Biochemistry & Molecular Biology
Callum Stewart-McGuinness, Christopher Platt, Matiss Ozols, Brian Goh, Tamara W. Griffiths, Michael J. Sherratt
Summary: This study used proteomics approaches to comprehensively analyze proteases and protease inhibitors in human skin, identifying various types of P/PIs and their distribution in normal and diseased skin. The results showed significant differences in the characteristics of P/PIs in different skin disease groups, suggesting a potential role of P/PIs in disease progression and providing important information for further research on the pathogenesis of skin diseases.
Article
Biochemical Research Methods
Cheng Li, Wei Dan, Pengfei Li, Miaomiao Xin, Rongxia Lan, Bojing Zhu, Zexuan Chen, Wenbo Dong, Liuyi Dang, Xinwen Zhang, Shisheng Sun
Summary: In this study, a glycoproteomic analysis of human semen during the liquefaction process was conducted. The analysis revealed that 25 intact glycopeptides from 10 glycoproteins were significantly changed, with half of them being modified with sialylated glycans. These findings provide valuable insights into the role of glycosylation during semen liquefaction.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Cameron Herberts, Matti Annala, Joonatan Sipola, Sarah W. S. Ng, Xinyi E. Chen, Anssi Nurminen, Olga Korhonen, Kevin Beja, Elena Schonlau, Cecily Q. Bernales, Elie Ritch, Jack V. W. Bacon, Nathan A. Lack, Matti Nykter, Rahul Aggarwal, Eric J. Small, Martin E. Gleave, David A. Quigley, Felix Y. Feng, Kim N. Chi, Alexander W. Wyatt
Summary: This study performed whole-genome sequencing of plasma and synchronous metastases in patients with aggressive prostate cancer, revealing multiple dominant populations in ctDNA and shifts in mutational processes. They found that AR augmentation is the dominant genomic driver of acquired treatment resistance.
Article
Plant Sciences
Zhenzhuo Li, Rui Jiang, Chenxu Jing, Jianzeng Liu, Xiaohao Xu, Liwei Sun, Daqing Zhao
Summary: The study found that the ginseng oligosaccharide extract can effectively repair UVB-induced skin barrier damage, alleviate skin dryness, and desquamation symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Joseph M. Chan, Samir Zaidi, Jillian R. Love, Jimmy L. Zhao, Manu Setty, Kristine M. Wadosky, Anuradha Gopalan, Zi-Ning Choo, Sitara Persad, Jungmin Choi, Justin LaClair, Kayla E. Lawrence, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Irina Linkov, Shangqian Wang, Cindy Lee, Afsar Barlas, Michael J. Morris, Linas Mazutis, Ronan Chaligne, Yu Chen, David W. Goodrich, Wouter R. Karthaus, Dana Pe'er, Charles L. Sawyers
Summary: Drug resistance in cancer is often associated with tumor cell lineage plasticity. The molecular mechanisms driving this plasticity have not been fully understood. This study shows that prostate cancer plasticity is initiated in a population of cells with mixed luminal-basal phenotype and is dependent on increased JAK and FGFR activity. Single-cell analysis in patients with metastatic disease confirms the presence of mixed-lineage cells with increased JAK/STAT and FGFR signaling.
Article
Multidisciplinary Sciences
Joleen P. Z. Goh, Fiorella Ruchti, Si En Poh, Winston L. C. Koh, Kiat Yi Tan, Yan Ting Lim, Steven T. G. Thng, Radoslaw M. Sobota, Shawn S. Hoon, Chenxi Liu, Anthony J. O'Donoghue, Salome LeibundGut-Landmann, Hazel H. Oon, Hao Li, Thomas L. Dawson
Summary: This study reveals differential expression of secretory enzymes in Malassezia globosa between healthy individuals and patients with seborrheic dermatitis or atopic dermatitis. Functional analysis of a homologous protease suggests its important role in altering cell adhesion and inflammation, highlighting the contextual relevance in evaluating the functions of secreted microbial enzymes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Eric Feng, Nicholas R. Rydzewski, Meng Zhang, Arian Lundberg, Matthew Bootsma, Kyle T. Helzer, Joshua M. Lang, Rahul Aggarwal, Eric J. Small, David A. Quigley, Martin Sjostrom, Shuang G. Zhao
Summary: In this study, the researchers identified the intrinsic molecular subtypes of metastatic castration-resistant prostate cancer (mCRPC) and assessed their molecular and clinical correlates using a large cohort with gene expression data. The results showed the heterogeneity of mCRPC beyond currently accepted molecular phenotypes, emphasizing the need for transcriptome-wide profiling in future studies to understand the impact of these differences on treatment responses and outcomes.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Ruo-Zhu Tai, El-Wui Loh, Jo-Ting Tsai, Ka-Wai Tam
Summary: Hyaluronic acid (HA) can alleviate RT-induced mucocutaneous side effects, including skin pain, desquamation, and severe mucosal problems. HA treatment is safe and has the potential for diverse pharmacotherapeutic applications.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Cell Biology
Lu Jin, Jin Zhu, Linya Yao, Gang Shen, Bo-xin Xue, Wei Tao
Summary: This study found that SphK1 and SphK2 are upregulated in human prostate cancer tissues. The use of SKI-178 effectively inhibits the growth and migration of prostate cancer cells, exerting cytotoxic effects through the inhibition of SphK activity and induction of ceramide production.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Simon J. de Veer, Joakim E. Swedberg, Muharrem Akcan, K. Johan Rosengren, Maria Brattsand, David J. Craik, Jonathan M. Harris
BIOCHEMICAL JOURNAL
(2015)
Article
Urology & Nephrology
Olivia Larne, Paivi Ostling, Benedikta S. Haflidadottir, Zandra Hagman, Anna Aakula, Pekka Kohonen, Olli Kallioniemi, Anders Edsjo, Anders Bjartell, Hans Lilja, Ake Lundwall, Yvonne Ceder
Article
Biochemistry & Molecular Biology
Simon J. de Veer, Joakim E. Swedberg, Maria Brattsand, Judith A. Clements, Jonathan M. Harris
BIOLOGICAL CHEMISTRY
(2016)
Article
Dermatology
Simon J. de Veer, Laetitia Furio, Joakim E. Swedberg, Christopher A. Munro, Maria Brattsand, Judith A. Clements, Alain Hovnanian, Jonathan M. Harris
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2017)
Article
Oncology
Tiphaine Delaunay, Lydia Deschamps, Meriem Haddada, Francine Walker, Antoninus Soosaipillai, Feryel Soualmia, Chahrazade El Amri, Eleftherios P. Diamandis, Maria Brattsand, Viktor Magdolen, Dalila Darmoul
MOLECULAR ONCOLOGY
(2017)
Article
Endocrinology & Metabolism
Erik Djusberg, Emma Jernberg, Elin Thysell, Irina Golovleva, Pia Lundberg, Sead Crnalic, Anders Widmark, Anders Bergh, Maria Brattsand, Pernilla Wikstroem
Article
Genetics & Heredity
Petr Kasparek, Zuzana Ileninova, Olga Zbodakova, Ivan Kanchev, Oldrich Benada, Karel Chalupsky, Maria Brattsand, Inken M. Beck, Radislav Sedlacek
Article
Biochemistry & Molecular Biology
Meriem Haddada, Hend Draoui, Lydia Deschamps, Francine Walker, Tiphaine Delaunay, Maria Brattsand, Viktor Magdolen, Dalila Darmoul
BIOLOGICAL CHEMISTRY
(2018)
Article
Hematology
Ake Lundwall
THROMBOSIS AND HAEMOSTASIS
(2013)
Article
Multidisciplinary Sciences
Xingchen Chen, Blake T. Riley, Simon J. de Veer, David E. Hoke, Jessica Van Haeften, Darren Leahy, Joakim E. Swedberg, Maria Brattsand, Perry J. Hartfield, Ashley M. Buckle, Jonathan M. Harris
Article
Chemistry, Medicinal
Xingchen Chen, Darren Leahy, Jessica Van Haeften, Perry Hartfield, Peter J. Prentis, Chloe A. van der Burg, Joachim M. Surm, Ana Pavasovic, Bruno Madio, Brett R. Hamilton, Glenn F. King, Eivind A. B. Undheim, Maria Brattsand, Jonathan M. Harris
Article
Endocrinology & Metabolism
Erik Bovinder Ylitalo, Elin Thysell, Camilla Thellenberg-Karlsson, Marie Lundholm, Anders Widmark, Anders Bergh, Andreas Josefsson, Maria Brattsand, Pernilla Wikstrom
Article
Oncology
Erik Bovinder Ylitalo, Elin Thysell, Mattias Landfors, Maria Brattsand, Emma Jernberg, Sead Crnalic, Anders Widmark, Magnus Hultdin, Anders Bergh, Sofie Degerman, Pernilla Wikstrom
Summary: Integrated epigenome and transcriptome analysis identified pronounced hypermethylation in malignant compared to non-malignant areas of localized prostate tumors. Metastases showed an overall hypomethylation in relation to primary PC, including CpGs in the AR promoter accompanied with induction of AR mRNA levels. We identified a Methylation Classifier for Androgen receptor activity (MCA) signature, which separated metastases into two clusters (MCA positive/negative) related to tumor characteristics and patient prognosis.
CLINICAL EPIGENETICS
(2021)
Article
Biochemistry & Molecular Biology
Ake Lundwall, Erik Bovinder Ylitalo, Pernilla Wikstroem, Maria Brattsand
Summary: KLK4 and its splice variant KLK4T2, as well as the pseudogene KLKP1, show differential expression patterns in prostate tissue, with potential implications for prostate cancer and benign prostatic hyperplasia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Helena Jaeremo, Julius Semenas, Sofia Halin Bergstroem, Marie Lundholm, Elin Thysell, Anders Widmark, Sead Crnalic, Erik Bovinder Ylitalo, Anders Bergh, Maria Brattsand, Pernilla Wikstroem
Summary: In prostate cancer progression to bone metastasis, certain miRNAs, including miRNA-23c and -4328, are downregulated and these changes impact the growth of prostate cancer. The downregulation of these miRNAs may result in a loss of tumor suppressive effects, providing potential biomarkers and treatment possibilities for further exploration.
