KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype

A viable mouse model for Netherton syndrome based on mosaic inactivation of the Spink5 gene

(2016) Petr Kasparek et al.   BIOLOGICAL CHEMISTRY

KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome

(2015) Laetitia Furio et al.   PLoS Genetics

Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer

(2014) Francine Walker et al.   BIOLOGICAL CHEMISTRY

Netherton syndrome: defective kallikrein inhibition in the skin leads to skin inflammation and allergy

(2014) Laetitia Furio et al.   BIOLOGICAL CHEMISTRY

Efficient gene targeting of theRosa26locus in mouse zygotes using TALE nucleases

(2014) Petr Kasparek et al.   FEBS LETTERS

Keratinocyte-Specific Mesotrypsin Contributes to the Desquamation Process via Kallikrein Activation and LEKTI Degradation

(2014) Masashi Miyai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes

(2013) Matyas Flemr et al.   CELL

Kallikrein-related Peptidase 5 Functions in Proteolytic Processing of Profilaggrin in Cultured Human Keratinocytes

(2013) Jun-ichi Sakabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease activity, localization and inhibition in the human hair follicle

(2013) R. K. Bhogal et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction

(2012) Erin L. Doyle et al.   NUCLEIC ACIDS RESEARCH

Proteolytic Activation Cascade of the Netherton Syndrome–Defective Protein, LEKTI, in the Epidermis: Implications for Skin Homeostasis

(2011) Paola Fortugno et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

Transgenic mouse model expressing tdTomato under involucrin promoter as a tool for analysis of epidermal differentiation and wound healing

(2011) Petr Kasparek et al.   TRANSGENIC RESEARCH

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

(2010) Chrystelle Bonnart et al.   JOURNAL OF CLINICAL INVESTIGATION

Par2 Inactivation Inhibits Early Production of TSLP, but Not Cutaneous Inflammation, in Netherton Syndrome Adult Mouse Model

(2010) Anaïs Briot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

New Role for LEKTI in Skin Barrier Formation: Label-Free Quantitative Proteomic Identification of Caspase 14 as a Novel Target for the Protease Inhibitor LEKTI

(2010) Kate Bennett et al.   JOURNAL OF PROTEOME RESEARCH

Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

(2010) Katiuchia Uzzun Sales et al.   NATURE GENETICS

Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction

(2009) E. A. Leclerc et al.   JOURNAL OF CELL SCIENCE

Filaggrin in the frontline: role in skin barrier function and disease

(2009) A. Sandilands et al.   JOURNAL OF CELL SCIENCE

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of Proteinase-Activated Receptor-2 by Human Kallikrein-Related Peptidases

(2007) Kristina Stefansson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY