Sirtuin deacetylases in neurodegenerative diseases of aging

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

2012 Alzheimer’s disease facts and figures

(2012)   Alzheimers & Dementia

Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice

(2012) Soyoung Han et al.   BRAIN RESEARCH

Enhancing clinical trials in neurodegenerative disorders

(2012) Matthew Gladman et al.   CURRENT OPINION IN NEUROLOGY

Aberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells

(2012) Vanessa Byles et al.   International Journal of Biological Sciences

Heat Shock and Caloric Restriction Have a Synergistic Effect on the Heat Shock Response in asir2.1-dependent Manner inCaenorhabditis elegans

(2012) Rachel Raynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Sirtuin Biology to Human Diseases: An Update

(2012) Carlos Sebastián et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

trans-(−)-ϵ-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease

(2012) Jinrong Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 2 (SIRT2) Enhances 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Nigrostriatal Damage via Deacetylating Forkhead Box O3a (Foxo3a) and Activating Bim Protein

(2012) Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integration of  -Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity

(2012) J. A. Parker et al.   JOURNAL OF NEUROSCIENCE

SIRT1 Protects against  -Synuclein Aggregation by Activating Molecular Chaperones

(2012) G. Donmez et al.   JOURNAL OF NEUROSCIENCE

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

(2012) Elisa Majounie et al.   LANCET NEUROLOGY

Attacking the flank: targeting new pathways in SBMA

(2012) Diane E Merry   NATURE MEDICINE

Finding a sirtuin truth in Huntington's disease

(2012) Albert R La Spada   NATURE MEDICINE

Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype

(2012) Matthis Synofzik et al.   NEUROBIOLOGY OF AGING

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

(2012) Wenjun Song et al.   NEUROBIOLOGY OF DISEASE

Differential Sirtuin Expression Patterns in Amyotrophic Lateral Sclerosis (ALS) Postmortem Tissue: Neuroprotective or Neurotoxic Properties of Sirtuins in ALS?

(2012) Sonja Körner et al.   Neurodegenerative Diseases

Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis

(2012) Edward Pokrishevsky et al.   PLoS One

SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo

(2012) Anna Bobrowska et al.   PLoS One

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

(2012) Melanie Gertz et al.   PLoS One

The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

(2012) Vanita Chopra et al.   Cell Reports

CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: Protection by resveratrol but not riluzole

(2011) Matilde Yáñez et al.   BRAIN RESEARCH

Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis

(2011) Jae Chul Lee et al.   BRAIN RESEARCH

Old Enzymes, New Tricks: Sirtuins Are NAD+-Dependent De-acylases

(2011) Matthew D. Hirschey   Cell Metabolism

Administration of resveratrol: What formulation solutions to bioavailability limitations?

(2011) A. Amri et al.   JOURNAL OF CONTROLLED RELEASE

SIRT1 Modulates Aggregation and Toxicity through Deacetylation of the Androgen Receptor in Cell Models of SBMA

(2011) H. L. Montie et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial

(2011) Lindsay E Fernández-Rhodes et al.   LANCET NEUROLOGY

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development

(2011) Dagmar E. Ehrnhoefer et al.   NATURE REVIEWS DRUG DISCOVERY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis

(2011) Jing Wang et al.   NEUROSCIENCE LETTERS

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

(2011) F Wang et al.   ONCOGENE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Emerging roles for cholesterol in Huntington's disease

(2011) Marta Valenza et al.   TRENDS IN NEUROSCIENCES

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

(2010) Daniel J. Ho et al.   EXPERIMENTAL NEUROLOGY

Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells

(2010) Toshiya Sugino et al.   FEBS LETTERS

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Single-Dose Resveratrol Treatment in a Mouse Model of Amyotrophic Lateral Sclerosis

(2010) Chad D. Markert et al.   JOURNAL OF MEDICINAL FOOD

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial

(2010) Masahisa Katsuno et al.   LANCET NEUROLOGY

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design

The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide

(2009) Diego Albani et al.   JOURNAL OF NEUROCHEMISTRY

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein

(2008) Tomoaki Kahyo et al.   FEBS LETTERS

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

(2008) Judit Pallos et al.   HUMAN MOLECULAR GENETICS

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

(2008) S. Hisahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice

(2008) Julie Blanchet et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics