Article
Multidisciplinary Sciences
Kiko Kanno, Yasunari Kayashima, Kazuji Tamura, Takako Miyara, Kento Baba, Megumi Koganei, Midori Natsume, Shinjiro Imai
Summary: This study aims to investigate the effects of cacao components on the lifespan of D. melanogaster as a model organism and elucidate its mechanism of action. The researchers found that fatty acid tryptamide in cacao can extend lifespan by activating sirtuins and increasing gene expression of heat shock proteins.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Ghaith Zamzam, Christopher W. J. Lee, Fiona Milne, Jenna Etsell, Dion G. Durnford
Summary: The mass cultivation of algal biomass faces challenges due to the underdeveloped concept of aging, which can affect biomass and bioproduct accumulation. This study examines the effects of acetate content on the longevity of Chlamydomonas reinhardtii and finds that acetate influences biomass accumulation, chlorophyll content, starch accumulation, and cell survival. High acetate levels are correlated with accelerated senescence and death.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Editorial Material
Immunology
Lukai Zhai, Connie M. Krawczyk
Summary: The reduction of SPARC during caloric restriction (CR) is found to offer beneficial effects by reducing SPARC-driven inflammatory phenotypes in macrophages.
Article
Multidisciplinary Sciences
Elite Possik, Laura-Lee Klein, Perla Sanjab, Ruyuan Zhu, Laurence Cote, Ying Bai, Dongwei Zhang, Howard Sun, Anfal Al-Mass, Abel Oppong, Rasheed Ahmad, Alex Parker, S. R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki
Summary: Excess nutrients can accelerate aging, but the newly discovered enzyme G3PP can counter metabolic stress and promote healthy aging in C. elegans. Overexpression of the C. elegans G3PP homolog, PGPH-2, decreases fat levels and mimics the effects of calorie restriction, particularly in glucotoxicity conditions, without reducing food intake. This overexpression depletes glycogen stores and activates AMPK, HLH-30, and autophagy, promoting healthy aging.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Yang Lyu, Kristina J. Weaver, Humza A. Shaukat, Marta L. Plumoff, Maria Tjilos, Daniel E. L. Promislow, Scott D. Pletcher
Summary: Diet choice affects behavior, metabolism, and lifespan in Drosophila, independent of the amount of nutrients consumed. This study reveals a mechanism of aging that applies in natural conditions, including our own, in which organisms continuously perceive and evaluate nutrient availability to promote fitness and well-being.
Review
Biochemistry & Molecular Biology
Tamara Dakic, Tanja Jevdjovic, Predrag Vujovic, Aleksandra Mladenovic
Summary: This review summarizes the current literature on caloric restriction as a potential life-prolonging intervention in humans, and discusses the metabolic pathways underlying this effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Otobong Donald Akan, Dandan Qin, Tianyi Guo, Qinlu Lin, Feijun Luo
Summary: Sirtfood is a type of food that targets SIRTs, which are important for reducing calorie intake and improving obesity and age-related metabolic diseases. Certain food ingredients are potential modulators of SIRTs, and proponents of Sirtfood believe it has significant health effects.
Article
Medicine, Research & Experimental
John Sylvester B. Nas, Paul Mark B. Medina
Summary: Sodium benzoate and sodium metabisulfite, common artificial preservatives in processed food, have unknown long-term effects on consumer health. Studies have shown potential toxic effects and an unexpected side effect of lifespan extension in animals. Animals fed with these preservatives also experienced reduced appetite and improved health, suggesting caloric restriction and possibly prolonged lifespan.
MEDICAL HYPOTHESES
(2023)
Article
Multidisciplinary Sciences
Daniel Promislow, Rozalyn M. Anderson, Marten Scheffer, Bernard Crespi, James DeGregori, Kelley Harris, Barbara Natterson Horowitz, Morgan E. Levine, Maria A. Riolo, David S. Schneider, Sabrina L. Spencer, Dario Riccardo Valenzano, Michael E. Hochberg
Summary: Aging research involves diverse disciplines, but lacks communication between them. Researchers propose that the concept of resilience can act as a bridge to connect these disciplines, thereby advancing research in the biology of aging.
Article
Cell Biology
Mark T. Mc Auley
Summary: Dietary restriction is an effective intervention for extending lifespan, but the mechanism behind it is still unclear. The prevailing belief is that dietary restriction promotes longevity through resource reallocation, but recent findings suggest this belief might be incomplete and there could be other factors influencing the evolutionary trade-offs of dietary restriction.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Review
Oncology
Erwan Eriau, Juliette Paillet, Guido Kroemer, Jonathan G. Pol
Summary: Reduced food intake and caloric restriction mimetics have been shown to increase healthy lifespan, reduce cancer incidence, and enhance responses to certain cancer treatments. These effects are mediated by cellular mechanisms and vary between cancer cells and healthy cells due to differences in metabolic requirements. Additionally, both reduced food intake and caloric restriction mimetics can induce autophagy, improving the efficacy of certain cancer treatments that induce immunogenic cell death and enhance the therapeutic efficacy of chemo-immunotherapies.
Article
Nutrition & Dietetics
Donato Angelino, Francesca Pietrangeli, Mauro Serafini
Summary: This study investigated the meal timing and dietary habits of nonagenarians and centenarians in the Abruzzo region, Italy. The results showed an early dinner and a significant calorie restriction period between dinner and lunch. The participants had a high consumption of plant-based foods and were physically active throughout their lives.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Katherine K. Clifton, Cynthia X. Ma, Luigi Fontana, Lindsay L. Peterson
Summary: Intermittent fasting (IF) has gained popularity as a potential anticarcinogenic strategy, but its effects on cancer patients remain unclear without high-quality randomized clinical trials. More research is needed to determine the risks and benefits of IF for cancer patients before it can be recommended outside of clinical trials.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Medicine, Research & Experimental
Evelyn Lopez Soares, Fabio Andre dos Santos, Tayline Mroczek, Debora Cristina de Lima, Hemily Victoria Bardini Josefino, Bruna Carolina Mehret Scorsin, Dionizia Xavier Scomparin, Gilson Cesar Nobre Franco
Summary: The study suggests that caloric restriction can reduce alveolar bone loss in obese rats with experimental periodontitis, while also benefiting glycemic profile and clinical periodontal measures.
Article
Medicine, Research & Experimental
Evelyn Lopez Soares, Fabio Andre dos Santos, Tayline Mroczek, Debora Cristina de Lima, Hemily Victoria Bardini Josefino, Luise Adrieli Bochenek da Silva, Leomar Emanuel Almeida Mecca, Gilson Cesar Nobre Franco
Summary: The study found that caloric restriction reduced alveolar bone loss, improved the glycemic profile, and alleviated gingival inflammation in rats with experimental periodontitis.