期刊
AGING-US
卷 1, 期 2, 页码 182-190出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100023
关键词
chromatin; histone; senescence; heterochromatin; methylation; nuclear organization
资金
- NIH [CA009161]
- American Federation for Aging Research (AFAR)
- The American Cancer Society (ACS)
An emerging field of investigation in the search for treatment of human disease is the modulation of chromatin modifications. Chromatin modifications impart virtually all processes occurring in the mammalian nucleus, from regulation of transcription to genomic stability and nuclear high order organization. It has been well recognized that, as the mammalian cell ages, its chromatin structure evolves, both at a global level and at specific loci. While these observations are mostly correlative, recent technical developments allowing loss-of-function experiments and genome-wide approaches have permitted the identification of a causal relationship between specific changes in chromatin structure and the aging phenotype. Here we review the evidence pointing to the modulation of chromatin structure as a potential driving force of cellular aging in mammals.
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