Mitochondria “fuel” breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells

TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome

(2012) Mohammed A. Aleskandarany et al.   BREAST CANCER RESEARCH AND TREATMENT

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

(2012) Barbara Chiavarina et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival

(2012) Karen N. Wu et al.   CELL CYCLE

Energy transfer in "parasitic" cancer metabolism

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Mitochondrial metabolism in cancer metastasis

(2012) Federica Sotgia et al.   CELL CYCLE

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

(2012) Adam Ertel et al.   CELL CYCLE

Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production

(2012) Ahmed F. Salem et al.   CELL CYCLE

Metabolic reprogramming and two-compartment tumor metabolism

(2012) Barbara Chiavarina et al.   CELL CYCLE

Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth

(2012) Valentina Carito et al.   CELL CYCLE

Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

(2012) Ahmed F. Salem et al.   CELL CYCLE

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

(2012) Claudia Capparelli et al.   CELL CYCLE

Ketone body utilization drives tumor growth and metastasis

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

(2012) Ahmed F. Salem et al.   CELL CYCLE

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production

(2012) Claudia Capparelli et al.   CELL CYCLE

Using the “reverse Warburg effect” to identify high-risk breast cancer patients

(2012) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

Power Surge: Supporting Cells “Fuel” Cancer Cell Mitochondria

(2012) Ubaldo E. Martinez-Outschoorn et al.   Cell Metabolism

Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer

(2012) Xing Hua et al.   Diagnostic Pathology

Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis

(2012) Jinxu Zhou et al.   JOURNAL OF NEURO-ONCOLOGY

Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts

(2012) Samantha A Simpkins et al.   JOURNAL OF PATHOLOGY

GOLPH3 overexpression correlates with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer

(2012) Huan Li et al.   Journal of Translational Medicine

High Expression of GOLPH3 in Esophageal Squamous Cell Carcinoma Correlates with Poor Prognosis

(2012) Jian-Hua Wang et al.   PLoS One

Therapeutic potential of mitochondrial translation inhibition for treatment of acute myeloid leukemia

(2012) Aaron D Schimmer et al.   Expert Review of Hematology

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

(2011) Federica Sotgia et al.   Annual Review of Pathology-Mechanisms of Disease

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

(2011) Stephanos Pavlides et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

(2011) Federica Sotgia et al.   BMC Medicine

Power Cut: Inhibiting Mitochondrial Translation to Target Leukemia

(2011) Marcus Järås et al.   CANCER CELL

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

Prognostic significance of tumor/stromal caveolin-1 expression in breast cancer patients

(2011) Niansong Qian et al.   CANCER SCIENCE

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

(2011) Dolores Di Vizio et al.   CELL CYCLE

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth

(2011) Renee M. Balliet et al.   CELL CYCLE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Stromal Caveolin-1 Expression in Breast Carcinoma. Correlation with Early Tumor Recurrence and Clinical Outcome

(2011) Saba Mohamed El-Gendi et al.   PATHOLOGY & ONCOLOGY RESEARCH

The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

(2011) Ja Seung Koo et al.   TUMOR BIOLOGY

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling

(2010) Gemma Migneco et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

Quantitative proteomics study of breast cancer cell lines isolated from a single patient: Discovery of TIMM17A as a marker for breast cancer

(2010) Xiaoen Xu et al.   PROTEOMICS

High TIMM17A expression is associated with adverse pathological and clinical outcomes in human breast cancer

(2010) Mohamed Salhab et al.   Breast Cancer

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

(2009) Erica K. Sloan et al.   AMERICAN JOURNAL OF PATHOLOGY

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer

(2008) Theresa Casey et al.   BREAST CANCER RESEARCH AND TREATMENT