HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

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An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

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Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

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Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

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The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

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Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

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Autophagy in cancer associated fibroblasts promotes tumor cell survival

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Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

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Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy and the degradation of mitochondria

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Caveolin-1−/− Null Mammary Stromal Fibroblasts Share Characteristics with Human Breast Cancer-Associated Fibroblasts

(2009) Federica Sotgia et al.   AMERICAN JOURNAL OF PATHOLOGY

Quis Custodiet Ipsos Custodies

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An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breast cancer by proxy: can the microenvironment be both the cause and consequence?

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