Article
Neurosciences
Shigeki Moriguchi, Ryo Inagaki, Takashi Saito, Takaomi C. Saido, Kohji Fukunaga
Summary: Propolis plays a therapeutic role in Alzheimer's disease and other neurodegenerative diseases. In mouse experiments, the combination of propolis and memantine enhances the rescue of cognitive deficits and increases ATP levels through the inhibition of the Kir6.2 channel.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Giulia Torromino, Adriana Maggi, Elvira De Leonibus
Summary: Women are more prone than men to develop age-related dementia, such as Alzheimer's disease, due to sex differences in the neurobiology of memory leading to lower usage of the hippocampus in females. The decreased utilization of the hippocampus makes women more vulnerable to the effects of ageing. It is suggested that exercise, cognitive training, and orienteering could be effective in preventing and counteracting Alzheimer's disease.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Ira Driscoll, Yue Ma, Catherine L. Gallagher, Sterling C. Johnson, Sanjay Asthana, Bruce P. Hermann, Mark A. Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Corinne D. Engelman, Dena B. Dubal, Ozioma C. Okonkwo
Summary: The study investigated whether carrying the advantageous KL-VS variant can attenuate age-related alterations in cerebrospinal fluid biomarkers or cognitive function in middle-aged and older adults, and found that individuals with the variant showed slower age-related changes in biomarkers and cognitive function, suggesting a protective effect against Alzheimer's disease risk.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Pharmacology & Pharmacy
Negin Mohammadi, Masoumeh Asle-Rousta, Mehdi Rahnema, Rahim Amini
Summary: The study showed that morin has potential therapeutic effects in Alzheimer's disease by reducing oxidative/nitrosative stress and neuroinflammation in the hippocampus, as well as improving memory function and neuronal survival.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qian Zhang, Qingxiang Song, Renhe Yu, Antian Wang, Gan Jiang, Yukun Huang, Jun Chen, Jianrong Xu, Dayuan Wang, Hongzhuan Chen, Xiaoling Gao
Summary: Mitochondrial dysfunction is a key factor in neurodegenerative diseases like Alzheimer's disease (AD). The dysregulation of mitochondrial calcium ion homeostasis and mPTP activation contribute to mitochondrial dysfunction in AD. A therapeutic strategy that combines a Ca2+ antagonist and siRNA to regulate mPTP is proposed. The treatment efficiently halts mitochondrial dysfunction and alleviates AD neuropathology.
Article
Chemistry, Multidisciplinary
Huarong Tan, Yuqi Huang, Shuqing Dong, Zetai Bai, Cheng Chen, Xiunan Wu, Minghao Chao, Hanrong Yan, Shaoshen Wang, Deqin Geng, Fenglei Gao
Summary: This article reports the development of a stimulus-responsive chiral nanomaterial, MSP-U, for the treatment of Alzheimer's disease. MSP-U stimulates neural stem cell differentiation, promotes in situ hydrogen production, and clears beta-amyloid plaques, showing promising potential as a treatment for AD using chiral nanomaterials.
Article
Neurosciences
Candice E. Van Skike, Stacy A. Hussong, Stephen F. Hernandez, Andy Q. Banh, Nicholas DeRosa, Veronica Galvan
Summary: The study reveals that in an Alzheimer's disease model, mTOR drives impairments in neurovascular coupling (NVC) through inhibition of neuronal nitric oxide synthase (nNOS) and non-NOS-dependent components. However, attenuation of mTOR activity effectively restores NVC function and can even enhance it above normal responses. This suggests that targeting mTOR may be a potential treatment for Alzheimer's disease and other neurological diseases associated with aging.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Stefanie Grabrucker, Moira Marizzoni, Edina Silajdzic, Nicola Lopizzo, Elisa Mombelli, Sarah Nicolas, Sebastian Dohm-Hansen, Catia Scassellati, Davide Vito Moretti, Melissa Rosa, Karina Hoffmann, John F. Cryan, Olivia F. O'Leary, Jane A. English, Aonghus Lavelle, Cora O'Neill, Sandrine Thuret, Annamaria Cattaneo, Yvonne M. Nolan
Summary: Recent research suggests that alterations in the gut microbiota are associated with Alzheimer's disease. Through transplantation of microbiota from Alzheimer's patients and healthy controls into rats, the study found that the microbiota from Alzheimer's patients affected memory and mood. Changes in hippocampal neurogenesis and metabolome were also observed in the rats.
Article
Pharmacology & Pharmacy
Lin Zhu, Fangjin Lu, Xiaoran Zhang, Siyuan Liu, Ping Mu
Summary: The study found that Pterostilbene (PTE) in blueberries has neuroprotective properties in the treatment of Alzheimer's disease, improving cognitive dysfunction and neuronal plasticity. Its mechanism may be related to inhibiting mitochondria-dependent apoptosis through the antioxidant effect regulated by SIRT1/Nrf2.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Eun-Young Lee
Summary: This study investigated the mechanisms underlying memory deficits in Parkinson's disease (PD) and their relationship with brain structural metrics. The findings showed that PD patients had lower memory capacity scores compared to controls in both memory experiments. Additionally, PD patients exhibited reduced cortical thickness in the left superior temporal gyrus, which was associated with lower memory scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Behavioral Sciences
Camila Andre Cazarin, Ana Paula Dalmagro, Ana Elisa Goncalves, Thaise Boeing, Luisa Mota da Silva, Rogerio Correa, Luiz Carlos Klein-Junior, Bernardo Carlesso Pinto, Thais Savoldi Lorenzett, Thales Uchoa da Costa Sobrinho, Angelo de Fatima, Tiago Coelho de Assis Lage, Sergio Antonio Fernandes, Marcia Maria de Souza
Summary: This study investigated the effects of UA enantiomers on cognitive deficits and neuroinflammation in mice with AD. The results showed that UA improved learning and memory, reduced oxidative stress markers, decreased neuroinflammation, and restored cognitive deficits induced by A beta 1-42 administration in mice.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Juyong Kim, Pilju Choi, Young-Tae Park, Taejung Kim, Jungyeob Ham, Jin-Chul Kim
Summary: Most studies on hemp have focused on CBD and THC, but there are up to 120 types of phytocannabinoids in hemp. CBDA and THCA, acidic variants of CBD and THC respectively, are present in large amounts in hemp leaves. Recent studies have shown that CBDA and THCA have anti-inflammatory and neuroprotective effects, and can penetrate the blood-brain barrier. This study aimed to investigate the effects of CBDA and THCA on Alzheimer's disease-like features in vitro and in vivo. The results suggest that CBDA and THCA have anti-AD effects and can improve cognitive function and reduce pathological markers of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shihong Li, Qiuzhi Zhou, Enjie Liu, Huiyun Du, Nana Yu, Haitao Yu, Weijin Wang, Mengzhu Li, Ying Weng, Yang Gao, Guilin Pi, Xin Wang, Dan Ke, Jian-Zhi Wang
Summary: The pathological accumulation of tau protein in mossy cells may induce spatial memory deficits resembling AD by inhibiting local neural network activity, revealing new pathogenesis and providing a mouse model for drug development.
Article
Biochemistry & Molecular Biology
Aseel El Hajj, Ameziane Herzine, Gaetano Calcagno, Frederic Desor, Fathia Djelti, Vincent Bombail, Isabelle Denis, Thierry Oster, Catherine Malaplate, Maxime Vigier, Sandra Kaminski, Lynn Pauron, Catherine Corbier, Frances T. Yen, Marie-Claire Lanhers, Thomas Claudepierre
Summary: Perturbations in cholesterol metabolism are linked to neurodegenerative diseases. The interaction between glial cells and neurons is essential for regulating brain cholesterol trafficking. The lipolysis-stimulated lipoprotein receptor (LSR) plays a crucial role in maintaining brain cholesterol homeostasis. Deficiency of astroglial LSR may result in cognitive defects and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Surendra Maharjan, Andy P. Tsai, Peter B. Lin, Cynthia Ingraham, Megan R. Jewett, Gary E. Landreth, Adrian L. Oblak, Nian Wang
Summary: This study evaluated the age-dependent microstructure changes in 5xFAD mice using high-resolution diffusion tensor imaging (DTI). The results showed that fractional anisotropy (FA) was more sensitive in monitoring amyloid deposition in the mice.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Alexandre Lacroix, Xavier Toussay, Eitan Anenberg, Clotilde Lecrux, Nerea Ferreiros, Anastassios Karagiannis, Fabrice Plaisier, Patrick Chausson, Frederic Jarlier, Sean A. Burgess, Elizabeth M. C. Hillman, Irmgard Tegeder, Timothy H. Murphy, Edith Hamel, Bruno Cauli
JOURNAL OF NEUROSCIENCE
(2015)
Review
Biology
C. Lecrux, E. Hamel
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2016)
Article
Neurosciences
Clotilde Lecrux, Claire H. Sandoe, Sujaya Neupane, Pascal Kropf, Xavier Toussay, Xin-Kang Tong, Maria Lacalle-Aurioles, Amir Shmuel, Edith Hamel
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Prateep Pakavathkumar, Anastasia Noel, Clotilde Lecrux, Agne Tubeleviciute-Aydin, Edith Hamel, Jan-Eric Ahlfors, Andrea C. LeBlanc
MOLECULAR NEURODEGENERATION
(2017)
Article
Neurosciences
Eduardo R. Zimmer, Maxime J. Parent, Debora G. Souza, Antoine Leuzy, Clotilde Lecrux, Hyoung-Ihl Kim, Serge Gauthier, Luc Pellerin, Edith Hamel, Pedro Rosa-Neto
NATURE NEUROSCIENCE
(2017)
Article
Pharmacology & Pharmacy
Brice Ongali, Nektaria Nicolakakis, Xin-Kang Tong, Clotilde Lecrux, Hans Imboden, Edith Hamel
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2018)
Review
Physiology
C. Lecrux, E. Hamel
Article
Pathology
Brice Ongali, Nektaria Nicolakakis, Clotilde Lecrux, Tahar Aboulkassim, Pedro Rosa Neto, Panayiota Papadopoulos, Xin Kang Tong, Edith Hamel
AMERICAN JOURNAL OF PATHOLOGY
(2010)
Article
Neurosciences
Julien Chuquet, Clotilde Lecrux, David Chatenet, Jerome Leprince, Laurent Chazalviel, Simon Roussel, Eric T. MacKenzie, Hubert Vaudry, Omar Touzani
EXPERIMENTAL NEUROLOGY
(2008)
Article
Endocrinology & Metabolism
Clotilde Lecrux, Ara Kocharyan, Claire H. Sandoe, Xin-Kang Tong, Edith Hamel
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2012)
Article
Neurosciences
Clotilde Lecrux, Xavier Toussay, Ara Kocharyan, Priscilla Fernandes, Sujay Neupane, Maxime Levesque, Fabrice Plaisier, Amir Shmuel, Bruno Cauli, Edith Hamel
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Brice Ongali, Nektaria Nicolakakis, Xin-Kang Tong, Tahar Aboulkassim, Panayiota Papadopoulos, Pedro Rosa-Neto, Clotilde Lecrux, Hans Imboden, Edith Hamel
NEUROBIOLOGY OF DISEASE
(2014)
Article
Clinical Neurology
Clotilde Lecrux, Christopher McCabe, Christopher J. Weir, Lindsay Gallagher, Jim Mullin, Omar Touzani, Keith W. Muir, Kennedy R. Lees, I. Mhairi Macrae
Article
Clinical Neurology
Clotilde Lecrux, Olivier Nicole, Laurent Chazalviel, Christelle Catone, Julien Chuquet, Eric T. MacKenzie, Omar Touzani