Letter
Immunology
Leon Caly, Ashleigh F. Porter, Joanna Chua, James P. Collet, Julian D. Druce, Michael G. Catton, Sebastian Duchene
Summary: During a mouse plague in early 2021, a farmer from New South Wales, Australia, was diagnosed with locally acquired lymphocytic choriomeningitis virus infection. Whole-genome sequencing revealed a divergent and geographically distinct strain of lymphocytic choriomeningitis virus compared to other published sequences.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Mark J. G. Bakkers, Alex Moon-Walker, Rasmus Herlo, Vesna Brusic, Sarah Hulsey Stubbs, Kathryn M. Hastie, Erica Ollmann Saphire, Tomas L. Kirchhausen, Sean P. J. Whelan
Summary: LCMV is a virus that enters cells by binding to different receptors and causes severe health problems. This study found that LCMV first binds to CD164 before entering cells, providing new targets for therapeutic interventions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Virology
Daniel Grupel, Yaniv Lustig, Tal Brosh-Nissimov
Summary: Lymphocytic choriomeningitis virus (LCMV) is an often-overlooked virus that can have severe consequences. We present the first documented infection by LCMV in Israel, and the epidemiology of LCMV is evolving with the potential for a worldwide endemicity, highlighting the need for increased awareness and testing.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pediatrics
Nicole S. Glaser, Kimberly S. Quayle, Julie K. McManemy, Lise E. Nigrovic, Leah Tzimenatos, Michael J. Stoner, Jonathan E. Bennett, Jennifer L. Trainor, Arleta Rewers, Jeff E. Schunk, Sage R. Myers, Maria Y. Kwok, Kathleen M. Brown, Simona Ghetti, T. Charles Casper, Cody S. Olsen, Nathan Kuppermann
Summary: This study found that lower pH and higher BUN levels at presentation are associated with cerebral injury.
JOURNAL OF PEDIATRICS
(2022)
Article
Microbiology
Jamin Liu, Kristeene A. Knopp, Elze Rackaityte, Chung Yu Wang, Matthew T. Laurie, Sara Sunshine, Andreas S. Puschnik, Joseph L. DeRisi
Summary: This study identifies novel host factors associated with Lymphocytic choriomeningitis virus (LCMV) infection of human tissues, highlighting the importance of CD164 in viral entry and suggesting it as a potential therapeutic target for congenital infection.
Article
Immunology
Jonathan Dyal, Shiv Gandhi, Caitlin M. Cossaboom, Austin Leach, Ketan Patel, Marjorie Golden, Joseph Canterino, Marie-Louise Landry, Debi Cannon, Mary Choi, Inna Krapiunaya, John D. Klena, Trevor Shoemaker
Summary: Lymphocytic choriomeningitis virus is an underreported cause of miscarriage and neurologic disease. Surveillance remains challenging due to nonspecific symptomatology, inconsistent case reporting, and difficulties with diagnostic testing.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Yuri Ushijima, Haruka Abe, Takehiro Ozeki, Georgelin N. Ondo, Marien J. V. M. Mbadinga, Rodrigue Bikangui, Chimene Nze-Nkogue, Etienne F. Akomo-Okoue, Ghislain W. E. Ella, Lilian B. M. Koumba, Branly C. B. B. Nso, Rodrigue Mintsa-Nguema, Patrice Makouloutou-Nzassi, Boris K. Makanga, Fred L. M. Nguelet, Vahid R. Zadeh, Shuzo Urata, Armel V. N. Mbouna, Marguerite Massinga-Loembe, Selidji T. Agnandji, Bertrand Lell, Jiro Yasuda
Summary: The study revealed a seroprevalence of 21.5% for LCMV in Gabon, with higher rates in males and adults. Local rodents, shrews, and porcupines around semi-urban areas posed an infection risk.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Peter Pankovics, Arnold Nagy, Zoltan Nyul, Annamaria Juhasz, Karoly Takats, Akos Boros, Gabor Reuter
Summary: This retrospective study aimed to detect lymphocytic choriomeningitis virus (LCMV) RNA in cerebrospinal fluid samples from patients with unknown central nervous system infections in Hungary. Two LCMV cases were identified, belonging to different genetic lineages. This is the first publication of confirmed human LCMV infections in Hungary using molecular methods.
ARCHIVES OF VIROLOGY
(2023)
Review
Medicine, General & Internal
Thomas Ferenc, Mateja Vujica, Anna Mrzljak, Tatjana Vilibic-Cavlek
Summary: This study summarizes the epidemiological, clinical, and diagnostic features of reported patients with congenital LCMV infection. A total of 27 studies with 86 patients were included, and the results showed that 52.73% of the patients were males. Common clinical manifestations included chorioretinitis, hydrocephalus, and psychomotor retardation or developmental delay. The diagnosis was most often confirmed serologically, and computed tomography and/or magnetic resonance imaging revealed ventriculomegaly, periventricular calcifications, and microcephaly. Mothers of congenitally infected infants were often exposed to mice during pregnancy, with flu-like symptoms occurring primarily in the first two trimesters.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Endocrinology & Metabolism
Arleta Rewers, Nathan Kuppermann, Michael J. Stoner, Aris Garro, Jonathan E. Bennett, Kimberly S. Quayle, Jeffrey E. Schunk, Sage R. Myers, Julie K. McManemy, Lise E. Nigrovic, Jennifer L. Trainor, Leah Tzimenatos, Maria Y. Kwok, Kathleen M. Brown, Cody S. Olsen, T. Charles Casper, Simona Ghetti, Nicole S. Glaser
Summary: In children treated for DKA, faster fluid administration rates led to a more rapid normalization of anion gap and Pco(2) than slower fluid infusion rates but were associated with an increased frequency of hyperchloremic acidosis.
Article
Clinical Neurology
Il-doo Kim, John W. Cave, Sunghee Cho
Summary: Obese mice with acute stroke showed increased mortality, infarct volume, swelling, and blood-brain barrier disruption, along with elevated VEGF-A and VEGFR2 expression. Aflibercept could reduce brain edema and vascular permeability, improving stroke outcomes in obese subjects.
Article
Chemistry, Multidisciplinary
Lianyong Han, Verena Haefner, Youjia Yu, Bing Han, Hongyu Ren, Martin Irmler, Johannes Beckers, Qiongliang Liu, Annette Feuchtinger, Ali Oender Yildirim, Heiko Adler, Tobias Stoeger
Summary: In this study, the effects of nanoparticle exposure on lung disease development and herpesvirus reactivation were investigated. The results showed that exposure to nanoparticles can induce lung inflammation and emphysema-like injury, as well as reactivate herpesvirus in lung macrophages. In vitro experiments demonstrated that nanoparticle exposure rapidly activates specific signaling pathways and increases viral gene expression without causing an inflammatory response. Pharmacological inhibition of p38 can effectively prevent nanoparticle-induced virus reactivation. These findings highlight the crucial role of nanoparticle-triggered herpesvirus reactivation in the development of lung diseases.
Article
Clinical Neurology
Daniel W. Griepp, Aaron Miller, Sahar Sorek, Stephanie Moawad, Ralph Rahme
Summary: Background: Bilaterally fixed and dilated pupils have traditionally been considered a sign of poor prognosis. This study aimed to determine the survival and functional outcome in patients who underwent aggressive medical and surgical management.
WORLD NEUROSURGERY
(2022)
Review
Clinical Neurology
Daniel W. Griepp, Aaron Miller, Sahar Sorek, Ralph Rahme
Summary: The study found that approximately 17% of patients with transtentorial herniation and BFDP had a favorable recovery following emergency decompressive surgery. In cases of stroke or trauma, BFDP should not be considered a sole indicator of futility.
WORLD NEUROSURGERY
(2022)
Article
Oncology
Maria J. Contreras-Zarate, Karen L. F. Alvarez-Eraso, Jenny A. Jaramillo-Gomez, Zachary Littrell, Nikki Tsuji, D. Ryan Ormond, Sana D. Karam, Peter Kabos, Diana M. Cittelly
Summary: This study aimed to determine whether radiation-associated treatment of breast-cancer brain metastases (BCBM) induces cytotoxic edema and the consequences of blocking the edema. The results showed that astrocytic swelling and upregulation of AQP4 occurred within 24 hours following radiation. Using anti-epileptic drugs that block AQP4 function can prevent radiation-induced cytotoxic edema.
Article
Biochemistry & Molecular Biology
Lauren A. O'Donnell, Kristen M. Henkins, Apurva Kulkarni, Christine M. Matullo, Siddharth Balachandran, Anil K. Pattisapu, Glenn F. Rall
JOURNAL OF NEUROCHEMISTRY
(2015)
Article
Multidisciplinary Sciences
Hila Naaman, Glenn Rall, Christine Matullo, Isana Veksler-Lublinsky, Yonat Shemer-Avni, Jacob Gopas
Article
Microbiology
Christine M. Matullo, Kevin J. O'Regan, Mark Curtis, Glenn F. Rall
Article
Virology
Katelyn D. Miller, Christine M. Matullo, Katelynn A. Milora, Riley M. Williams, Kevin J. O'Regan, Glenn F. Rall
JOURNAL OF VIROLOGY
(2019)
Article
Virology
Katelyn D. Miller, Christine Matullo, Riley Williams, Carli B. Jones, Glenn F. Rall
Summary: BST2/tetherin is a transmembrane protein synthesized following exposure to interferons, with antiviral activity. This protein was found to promote MV infection in brains of permissive mice and in primary neuron cultures, in contrast to its antiviral role in non-neuronal cells. The cell-type dependent role of BST2 in enhancing neuronal infection is highlighted in these studies.
Article
Genetics & Heredity
F Parviz, C Matullo, WD Garrison, L Savatski, JW Adamson, G Ning, KH Kaestner, JM Rossi, KS Zaret, SA Duncan