Article
Pharmacology & Pharmacy
Natsumi Mizuno, Yoshiki Yanagawa
Summary: In this study, it was found that tofacitinib enhanced IFN-gamma-induced MHC II expression in macrophages by transcriptional regulation through induction of CIITA, while decreasing the expression of CD86.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Adrianna Piatakova, Ingrid Polakova, Jana Smahelova, Shweta Dilip Johari, Jaroslav Nunvar, Michal Smahel
Summary: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment and their response to immunotherapy can vary depending on the expression of MHC-I molecules in the tumor. This study found that TAMs in tumors with distinct MHC-I expression levels show different immune reactions and cytotoxic capabilities. Consideration of these differences in TAMs is important for the development of effective cancer immunotherapies.
Article
Medicine, Research & Experimental
Shivai Gupta, Danmeng Li, David A. Ostrov, Cuong Q. Nguyen
Summary: This study proposes a novel therapeutic approach for SjS by blocking MHC class II I-Ag-7 antigen presentation in NOD mice. The results demonstrate that treating NOD mice with TATD or 8-Azaguanine can alleviate SjS symptoms and reduce the severity of the disease.
Article
Biology
Orsolya Vincze, Claire Loiseau, Mathieu Giraudeau
Summary: High MHC class I diversity is associated with significantly lower richness of haemosporidian parasites in birds, indicating more efficient protection against intracellular pathogens. However, these associations were only detected when MHC diversity was assessed using cloning, suggesting the need for further clarification on the use of different genotyping methods for MHC loci quantification.
Article
Biochemistry & Molecular Biology
Ankur Saikia, Andries Hadeler, Pranathi Prasad, Martin Zacharias, Sebastian Springer
Summary: This study investigates the importance of peptide exchange in immunodominance and uncovers the mechanism of peptide exchange under low pH conditions. The results demonstrate that low pH triggers peptide exchange and provide insights into the individual steps of the exchange reaction.
Article
Cell Biology
Yi-Hsin Liang, Kuo-Hsing Chen, Jia-Huei Tsai, Yung-Ming Cheng, Chang-Cheng Lee, Chiu-Hwa Kao, Kuang-Yu Chan, Yeh-Ting Chen, Wen-Ling Hsu, Kun-Huei Yeh
Summary: The study suggests a novel rationale for incorporating the proteasome inhibitor bortezomib into new immunotherapy combinations, which can enhance the expression of immune surface markers and improve tumor cell immunogenicity by activating the STAT1/pSTAT1 pathway.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Katherine R. Martin, Katherine L. Mansfield, Anna E. Savage
Summary: Characterizing MHC genes' polymorphism is crucial for understanding vertebrates' immune response to disease. This study explores the immunogenetic variation in sea turtles afflicted by fibropapillomatosis, a global infectious tumour disease. Extensive variation and trans-species polymorphism were recovered in MHC class I genes among green and loggerhead sea turtles. Supertyping analysis identified three functional MHC supertypes corresponding to well-supported clades in the phylogeny. Positive selection at seven amino acid sites in the class I exon was observed. One allele weakly associated with a specific tumour texture was found, suggesting a potential link between MHC diversity and disease outcome. This study highlights the importance of evaluating genetic predictors of disease, including MHC and other functional markers, in sea turtles.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Multidisciplinary Sciences
Di Zhang, Kefang Liu, Dan Lu, Pengyan Wang, Qingxu Zhang, Peipei Liu, Yingze Zhao, Yan Chai, Jianxin Lyu, Jianxun Qi, William J. Liu
Summary: The study focuses on the use of heterologous beta(2)-microglobulin (beta(2)m) substitution to stabilize MHC I in mammals, providing methods for expression construct preparation, inclusion body purification, MHC complex refolding, protein thermostability determination, crystal screening, and structure determination.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Psychiatry
Adam Pavlinek, Rugile Matuleviciute, Laura Sichlinger, Lucia Dutan Polit, Nikolaos Armeniakos, Anthony Christopher Vernon, Deepak Prakash Srivastava
Summary: Maternal immune activation during gestation is linked to increased risk for psychiatric disorders with neurodevelopmental origin. Animal and human cellular models suggest that inflammatory cytokines play a critical role in the impact of maternal infection on offspring brain and behavior development. However, the specific cytokines necessary for these effects and their impact on specific cell types are still unclear.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Pediatrics
Ramesh Radhika, Milind S. Tullu, Sunil Karande, Umair Ahmed Bargir
Summary: Major Histocompatibility Complex (MHC) Class II deficiency is a rare autosomal recessive primary immunodeficiency caused by mutations in regulatory genes of MHC Class II proteins. This case report describes a 9-month-old girl presenting with repeated pneumonia, lymphocytopenia, and absence of HLA-DR expression on B cells, which led to the diagnosis of MHC Class II deficiency. Genetic analysis identified a homozygous mutation in the RFX-5 gene. Despite the patient's unfortunate outcome, the importance of prenatal diagnosis was emphasized to the parents.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Ping Xia, Yu-Quan Shao, Cong-Cong Yu, Yu Xie, Zhi-Jie Zhou
Summary: This study found that the NLRP3 inflammasome plays an important role in the pathogenesis of polymyositis (PM). Inhibiting NLRP3 activation may hold promise for the treatment of PM.
Review
Biochemistry & Molecular Biology
Elena Shklovskaya, Helen Rizos
Summary: It is well acknowledged that the immune system plays a role in controlling tumor growth, but tumors can escape immune surveillance through mechanisms like downregulation or loss of MHC-I molecules. This review examines the dysregulation of MHC-I expression in cancer, the nature of MHC-I-bound antigenic peptides, and discusses therapeutic strategies to address MHC-I deficiency in solid tumors with a focus on NK cells and CD4 T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Denise S. M. Boulanger, Leon R. Douglas, Patrick J. Duriez, Yoyel Kang, Neil Dalchau, Edd James, Tim Elliott
Summary: Tapasin, a component of MHC I peptide loading complex, plays a key role in shaping the hierarchy of CD8+ T-cell responses to tumors and pathogens by editing the repertoire of peptides presented at the cell surface. The level of tapasin expression affects peptide off-rate and abundance, and each peptide has a unique tapasin bonus fingerprint. Optimal tapasin expression level varies for each peptide in the immunopeptidome, depending on its off-rate and abundance. This finding is important in understanding immune responses and immune escape.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Zoology
Diana D. Moreno-Santillan, Carlos Machain-Williams, Georgina Hernandez-Montes, Jorge Ortega
Summary: This study focused on the major histocompatibility complex (MHC) of bats and discovered functional variants of MHC class I transcripts that may have adaptive functions through the analysis of five species from different families of New World bats.
JOURNAL OF MAMMALOGY
(2022)
Article
Virology
Bryan D. Griffin, Juan Carlos Corredor, Yanlong Pei, Eva Nagy
Summary: The study reveals that representative virus isolates of Fowl aviadenovirus C, Fowl aviadenovirus D, and Fowl aviadenovirus E downregulate the cell surface expression of MHC-I in chicken hepatoma cells. The findings also show that FAdV-9 downregulates cell surface MHC-I through two separate mechanisms, one of which involves the FE1 transcription unit. These results provide new insights into the immune evasion strategies of FAdVs and have implications for understanding inclusion body hepatitis pathogenesis and advancing the development of next-generation FAdV-based vectors.
Article
Biochemistry & Molecular Biology
Zhixia Zhou, Chengyu Yang, Fuyan Lv, Wenmiao Liu, Shengli Yan, Hongwei Zang, Miaomiao Li, Fang Wang, Yucui Zang, Shiguo Liu
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Xin Pang, Zhixia Zhou, Zhuang Yu, Lichun Han, Zhijuan Lin, Xiang Ao, Chang Liu, Yuqi He, Murugavel Ponnusamy, Peifeng Li, Jianxun Wang
Review
Oncology
Zhixia Zhou, Qi Gong, Zhijuan Lin, Yin Wang, Mengkun Li, Lu Wang, Hongfei Ding, Peifeng Li
FRONTIERS IN ONCOLOGY
(2020)
Review
Oncology
Zhixia Zhou, Qi Gong, Yin Wang, Mengkun Li, Lu Wang, Hongfei Ding, Peifeng Li
BIOMARKER RESEARCH
(2020)
Article
Oncology
Peipei Shan, Feifei Yang, Hongzhao Qi, Yunjie Hu, Sujie Zhu, Zhenqing Sun, Zhe Zhang, Chuanxiao Wang, Caixia Hou, Jie Yu, Lirong Wang, Zhixia Zhou, Peifeng Li, Hua Zhang, Kun Wang
Summary: The study reveals the essential role of MDM2 in TNBC progression, suggesting that targeting the HDAC1-MDM2-MDMX axis with a hydroxamate-based HDAC1 could be a promising therapeutic strategy for TNBC.
Review
Oncology
Zhixia Zhou, Yinfeng Zhang, Jinning Gao, Xiaodan Hao, Chan Shan, Jing Li, Cuiyun Liu, Yin Wang, Peifeng Li
Summary: Circular RNAs (circRNAs) and autophagy are closely linked in the occurrence and development of cancer, with circRNAs influencing cancer progression by activating or inhibiting autophagy. Research has shown that the regulatory role of circRNAs in cancer is crucial for understanding the mechanisms of carcinogenesis.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Medicine, General & Internal
Xiao-Dan Hao, Hua Gao, Wen-Hua Xu, Chan Shan, Ying Liu, Zhi-Xia Zhou, Kun Wang, Pei-Feng Li
Summary: Keratoconus is an etiologically heterogeneous corneal ectatic disorder. This study reviewed and analyzed genes, gene ontology (GO), and pathways involved in keratoconus, and found potential relationships and mechanisms related to the pathogenesis of keratoconus. The study provides insights into the gene-based etiology and pathogenesis of keratoconus.
FRONTIERS IN MEDICINE
(2022)
Review
Oncology
Zhixia Zhou, Zhan Wang, Jie Gao, Zhijuan Lin, Yin Wang, Peipei Shan, Mengkun Li, Tingting Zhou, Peifeng Li
Summary: This review focuses on the regulation of noncoding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, in the crosstalk between macrophages and tumor cells in hepatocellular carcinoma (HCC). These ncRNAs act as oncogenes or tumor suppressors, contributing to tumor progression by regulating the physiological and pathological processes of tumor cells as well as controlling macrophage infiltration, activation, polarization, and function. The review also explores the potential therapeutic strategies targeting crosstalk-related ncRNAs for HCC treatment.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Cell & Tissue Engineering
Yalan Xu, Jie Mu, Zhixia Zhou, Yu Leng, Yali Yu, Xiuyue Song, Aihua Liu, Hai Zhu, Jing Li, Dong Wang
Summary: The study isolated and cultured a novel type of castration-resistant intermediate prostate stem cells that can rapidly proliferate in 2D culture dishes and be maintained for over six months. These stem cells express markers of both basal and luminal cells, and can differentiate into prostate organoids and tissues.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Fisheries
Zhixia Zhou, Yanxin He, Shoushi Wang, Yin Wang, Peipei Shan, Peifeng Li
Summary: Autophagy is a conserved cellular process essential for maintaining metabolism and energy balance, with implications in various physiological functions and clinical diseases. However, little is known about autophagy in teleost fish. This review provides an overview of the current knowledge of autophagy in teleosts, focusing on its physiological and pathological regulation in different processes. The potential options for targeting autophagy in teleosts for domestication, farming, or therapeutic strategies are also explored.
Review
Pharmacology & Pharmacy
Zhixia Zhou, Qianqian Cao, Yujing Diao, Yin Wang, Linhai Long, Shoushi Wang, Peifeng Li
Summary: In recent years, natural active substances from the marine environment have attracted great attention in the development of new antitumor drugs. Although a series of marine-derived compounds with potential antitumor effects have been discovered, their mechanisms of action are still not well understood. Emerging studies have found that noncoding RNAs (ncRNAs) play important roles in the antitumor mechanisms of marine-derived agents. This review summarizes the latest research progress on the regulation of ncRNAs associated with marine-derived agents in tumor cell proliferation, apoptosis, cell cycle, invasion, migration, drug sensitivity, and resistance. The review also discusses recent advances in marine food-derived ncRNAs as antitumor agents that modulate cross-species gene expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Zhixia Zhou, Cuibo Leng, Zhan Wang, Linhai Long, Yiju Lv, Ziru Gao, Yin Wang, Shoushi Wang, Peifeng Li
Summary: Research in the past two decades has confirmed that noncoding RNAs (ncRNAs), present in cells from yeast to vertebrates, are functional regulators involved in cellular and physiological processes. Dysregulation of ncRNAs is linked to imbalances in cellular homeostasis and the development of diseases. In mammals, ncRNAs like long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) serve as biomarkers and intervention targets in growth, development, immunity, and disease progression. The lncRNA-miRNA-mRNA axis, in which lncRNAs act as competing endogenous RNAs (ceRNAs), is the predominant mode of lncRNA-miRNA crosstalk. However, the role and mechanism of the lncRNA-miRNA-mRNA axis in teleost species have received little attention. This review provides an overview of the physiological and pathological regulation of the teleost lncRNA-miRNA-mRNA axis in growth and development, reproduction, skeletal muscle, immunity to bacterial and viral infections, and stress-related immune responses. It also explores the potential application of the lncRNA-miRNA-mRNA axis in the aquaculture industry.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Xiao-Ru Liang, Yan-Fei Liu, Feng Chen, Zhi-Xia Zhou, Li-Jie Zhang, Zhi-Juan Lin
Summary: Long non-coding RNAs (lncRNAs) are involved in various biological processes and regulate key proteins in the cell cycle of cancer cells. Understanding their role in cell cycle regulation can lead to new therapeutic strategies for cancer treatment. This review article summarizes recent studies on lncRNA control of cell cycle-related proteins and discusses their emerging role in cancer diagnosis and therapy.
CANCER MANAGEMENT AND RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Shuyuan Yi, Xinyi Tao, Yin Wang, Qianqian Cao, Zhixia Zhou, Shoushi Wang
Summary: Macrophages, along with monocytes and dendritic cells, make up the monocyte immune system, which plays a crucial role in immune response. Propofol, a commonly used anesthetic, has various effects including anti-inflammatory and anti-oxidation properties. This article summarizes the effects of propofol on macrophage functions in inflammation, infection, tumors, and organ reperfusion injury, and discusses its impact on pathology and prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chan Shan, Xinzhe Chen, Hongjing Cai, Xiaodan Hao, Jing Li, Yinfeng Zhang, Jinning Gao, Zhixia Zhou, Xinmin Li, Cuiyun Liu, Peifeng Li, Kun Wang
Summary: Autophagy is a crucial process in maintaining cell homeostasis and abnormal autophagy is associated with various diseases, including cancer. MicroRNAs (miRNAs) regulate gene expression and play important roles in fundamental biological processes like autophagy. Studying autophagy-related miRNAs in cancer can offer insights into cancer biology and support the development of novel anti-cancer strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)