标题
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 13, Pages 6741
出版商
MDPI AG
发表日期
2021-06-23
DOI
10.3390/ijms22136741
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy
- (2021) Akhil Shukla et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- CD4 T cell dependent rejection of beta 2 microglobulin null mismatch repair deficient tumors
- (2021) Giovanni Germano et al. Cancer Discovery
- Most non-canonical proteins uniquely populate the proteome or immunopeptidome
- (2021) Maria Virginia Ruiz Cuevas et al. Cell Reports
- Neoantigen-reactive T cells exhibit effective anti-tumor activity against colorectal cancer
- (2021) Yaojun Yu et al. Human Vaccines & Immunotherapeutics
- Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals
- (2021) Arne Claeys et al. PLoS Genetics
- Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation
- (2021) Karthik Dhatchinamoorthy et al. Frontiers in Immunology
- LincRNA-immunity landscape analysis identifies EPIC1 as a regulator of tumor immune evasion and immunotherapy resistance
- (2021) Weiwei Guo et al. Science Advances
- Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma
- (2021) Rana Falahat et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tissue Determinants of Human NK Cell Development, Function, and Residence
- (2020) Pranay Dogra et al. CELL
- NLRC5: new cancer buster?
- (2020) Feng Tang et al. MOLECULAR BIOLOGY REPORTS
- B cells are associated with survival and immunotherapy response in sarcoma
- (2020) Florent Petitprez et al. NATURE
- Tertiary lymphoid structures improve immunotherapy and survival in melanoma
- (2020) Rita Cabrita et al. NATURE
- B cells and tertiary lymphoid structures promote immunotherapy response
- (2020) Beth A. Helmink et al. NATURE
- Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells
- (2020) Jason B. Williams et al. Nature Communications
- PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade
- (2020) Marcel P. Trefny et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
- (2020) Jenny H. Lee et al. Nature Communications
- Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity
- (2020) Lauren K. Zebertavage et al. Scientific Reports
- MHC-I genotype and tumor mutational burden predict response to immunotherapy
- (2020) Aaron M. Goodman et al. Genome Medicine
- Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues
- (2020) Jean-David Larouche et al. Genome Medicine
- Inhibition of MICA and MICB Shedding Elicits NK-Cell–Mediated Immunity against Tumors Resistant to Cytotoxic T Cells
- (2020) Lucas Ferrari de Andrade et al. Cancer Immunology Research
- Neoantigen prediction and computational perspectives towards clinical benefit: recommendations from the ESMO Precision Medicine Working Group
- (2020) L. De Mattos-Arruda et al. ANNALS OF ONCOLOGY
- Cetuximab-induced natural killer cell cytotoxicity in head and neck squamous cell carcinoma cell lines: investigation of the role of cetuximab sensitivity and HPV status
- (2020) Hasan Baysal et al. BRITISH JOURNAL OF CANCER
- IL-6-induced CD39 expression on tumor-infiltrating NK cells predicts poor prognosis in esophageal squamous cell carcinoma
- (2020) Yujia Zheng et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer
- (2020) David Y. Oh et al. CELL
- IL15 Stimulation with TIGIT Blockade Reverses CD155-mediated NK-Cell Dysfunction in Melanoma
- (2020) Joe-Marc Chauvin et al. CLINICAL CANCER RESEARCH
- Phase I Trial of Expanded, Activated Autologous NK-cell Infusions with Trastuzumab in Patients with HER2-positive Cancers
- (2020) Soo-Chin Lee et al. CLINICAL CANCER RESEARCH
- To TAP or not to TAP: alternative peptides for immunotherapy of cancer
- (2020) Koen A. Marijt et al. CURRENT OPINION IN IMMUNOLOGY
- MHC class I transactivator NLRC5 in host immunity, cancer and beyond
- (2020) Steven X. Cho et al. IMMUNOLOGY
- Cancer Associated Endogenous Retroviruses: Ideal Immune Targets for Adenovirus-Based Immunotherapy
- (2020) Amaia Vergara Bermejo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Natural killer cell impairment in ovarian clear cell carcinoma
- (2020) Ornella Patrizi et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Co-Regulation of Immune Checkpoint PD-L1 with Interferon-Gamma Signaling is Associated with a Survival Benefit in Renal Cell Cancer
- (2020) Jörg Hänze et al. Targeted Oncology
- Uncovering the Tumor Antigen Landscape: What to Know about the Discovery Process
- (2020) Sara Feola et al. Cancers
- Effects of B cell–activating factor on tumor immunity
- (2020) Mark Yarchoan et al. JCI Insight
- Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma
- (2020) Catherine S. Grasso et al. CANCER CELL
- Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors
- (2020) Vid Leko et al. CANCER CELL
- PD‐1‐expressing CD56‐negative NK cell expansion is a hallmark of chronic NK cell activation during dasatinib treatment
- (2020) Ken‐ichi Ishiyama et al. CANCER SCIENCE
- Genome and transcriptome biomarkers of response to immune checkpoint inhibitors in advanced solid tumours
- (2020) Alexandra Pender et al. CLINICAL CANCER RESEARCH
- Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy
- (2020) Elena Shklovskaya et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Role of Human Leukocyte Antigen System as A Predictive Biomarker for Checkpoint-Based Immunotherapy in Cancer Patients
- (2020) Francesco Sabbatino et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies
- (2020) Shogo Kumagai et al. NATURE IMMUNOLOGY
- Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors
- (2020) Iván Márquez-Rodas et al. Science Translational Medicine
- Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma
- (2020) Anusha Kalbasi et al. Science Translational Medicine
- The Origin and Immune Recognition of Tumor-Specific Antigens
- (2020) Anca Apavaloaei et al. Cancers
- MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation
- (2020) Yuanzhang Fang et al. JOURNAL OF CLINICAL INVESTIGATION
- Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of Herpes Simplex Oncolytic Virus
- (2020) Guendalina Froechlich et al. Cancers
- The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker
- (2020) Denis L. Jardim et al. CANCER CELL
- Tumor mutational load predicts survival after immunotherapy across multiple cancer types
- (2019) Robert M. Samstein et al. NATURE GENETICS
- Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition
- (2019) Daisuke Ennishi et al. Cancer Discovery
- Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance
- (2019) Jiajie Wei et al. MOLECULAR CELL
- First-Line Nivolumab Plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer (CheckMate 568): Outcomes by Programmed Death Ligand 1 and Tumor Mutational Burden as Biomarkers
- (2019) Neal Ready et al. JOURNAL OF CLINICAL ONCOLOGY
- Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy
- (2019) Tuba N. Gide et al. CANCER CELL
- TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer
- (2019) Yujia Zheng et al. Journal of Translational Medicine
- A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients
- (2019) Joseph Cursons et al. Cancer Immunology Research
- The mechanism of anti-PD-L1 antibody efficacy against PD-L1 negative tumors identifies NK cells expressing PD-L1 as a cytolytic effector
- (2019) Wenjuan Dong et al. Cancer Discovery
- Systemic Interferon-γ Increases MHC Class I Expression and T-cell Infiltration in Cold Tumors: Results of a Phase 0 Clinical Trial
- (2019) Shihong Zhang et al. Cancer Immunology Research
- Determinants for Neoantigen Identification
- (2019) Andrea Garcia-Garijo et al. Frontiers in Immunology
- An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
- (2019) Marian L. Burr et al. CANCER CELL
- CD4+ T cells indirectly kill tumor cells via induction of cytotoxic macrophages in mouse models
- (2019) Bjarne Bogen et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade
- (2019) Joseph L. Benci et al. CELL
- Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence
- (2019) Michal Harel et al. CELL
- Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction
- (2019) Jennifer G. Abelin et al. IMMUNITY
- Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
- (2019) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion
- (2019) Andrew J. Freeman et al. Cell Reports
- STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity
- (2019) Rana Falahat et al. Cancer Immunology Research
- Cancer immune escape: MHC expression in primary tumours versus metastases
- (2019) Federico Garrido et al. IMMUNOLOGY
- MHC-II neoantigens shape tumour immunity and response to immunotherapy
- (2019) Elise Alspach et al. NATURE
- Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
- (2019) Diego Chowell et al. NATURE MEDICINE
- IPD-IMGT/HLA Database
- (2019) James Robinson et al. NUCLEIC ACIDS RESEARCH
- MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway
- (2019) Wei Yang et al. ONCOGENE
- A subset of patients with MSS/MSI‑low‑colorectal cancer showed increased CD8(+) TILs together with up‑regulated IFN‑γ
- (2019) Tomohiro Kikuchi et al. Oncology Letters
- Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
- (2019) Greta Garrido et al. Nature Communications
- TCRpMHCmodels: Structural modelling of TCR-pMHC class I complexes
- (2019) Kamilla Kjærgaard Jensen et al. Scientific Reports
- A Review of Viral-Related Malignancies and the Associated Imaging Findings
- (2019) Nikita Consul et al. AMERICAN JOURNAL OF ROENTGENOLOGY
- Comprehensive characterization of tumor infiltrating natural killer cells and clinical significance in hepatocellular carcinoma based on gene expression profiles
- (2019) Mei Wu et al. BIOMEDICINE & PHARMACOTHERAPY
- CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment
- (2019) Shi Yong Neo et al. JOURNAL OF CLINICAL INVESTIGATION
- Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with high accuracy
- (2019) Jeffrey C. Thompson et al. LUNG CANCER
- Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
- (2019) David Liu et al. NATURE MEDICINE
- Genome-Wide CRISPR Screen Reveals Cancer Cell Resistance to NK Cells Induced by NK-Derived IFN-γ
- (2019) Xiaoxuan Zhuang et al. Frontiers in Immunology
- A Phase 1 Trial of CNDO-109–Activated Natural Killer Cells in Patients with High-Risk Acute Myeloid Leukemia
- (2018) Todd A. Fehniger et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
- (2018) Jennifer Tsoi et al. CANCER CELL
- The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression
- (2018) Lu Huang et al. CLINICAL CANCER RESEARCH
- Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non–Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab
- (2018) Brandon W. Higgs et al. CLINICAL CANCER RESEARCH
- The Immune Landscape of Cancer
- (2018) Vésteinn Thorsson et al. IMMUNITY
- Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer
- (2018) Takeshi Ishikawa et al. INTERNATIONAL JOURNAL OF CANCER
- Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma
- (2018) Joshua R. Veatch et al. JOURNAL OF CLINICAL INVESTIGATION
- TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class I low cancers
- (2018) Koen A. Marijt et al. MOLECULAR IMMUNOLOGY
- Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses
- (2018) Israel Cañadas et al. NATURE MEDICINE
- Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
- (2018) Michael A. Postow et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Role of Mass Spectrometry and Proteogenomics in the Advancement of HLA Epitope Prediction
- (2018) Amanda L. Creech et al. PROTEOMICS
- Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity
- (2018) Lucas Ferrari de Andrade et al. SCIENCE
- A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing
- (2018) Deng Pan et al. SCIENCE
- The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients
- (2018) Vyara Matson et al. SCIENCE
- MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma
- (2018) Scott J. Rodig et al. Science Translational Medicine
- DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer
- (2018) Na Luo et al. Nature Communications
- Genetic Mechanisms of Immune Evasion in Colorectal Cancer
- (2018) Catherine S. Grasso et al. Cancer Discovery
- IL21 Therapy Combined with PD-1 and Tim-3 Blockade Provides Enhanced NK Cell Antitumor Activity against MHC Class I–Deficient Tumors
- (2018) Hyungseok Seo et al. Cancer Immunology Research
- NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives
- (2018) Remy Thomas et al. Frontiers in Immunology
- Interferon Signaling Is Frequently Downregulated in Melanoma
- (2018) Sara Alavi et al. Frontiers in Immunology
- Complex pattern of immune evasion in MSI colorectal cancer
- (2018) Mine Ozcan et al. OncoImmunology
- MAL2 promotes proliferation, migration, and invasion through regulating epithelial-mesenchymal transition in breast cancer cell lines
- (2018) Adheesh Bhandari et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
- (2018) K. G. Paulson et al. Nature Communications
- Combined analysis of antigen presentation and T cell recognition reveals restricted immune responses in melanoma
- (2018) Shelly Kalaora et al. Cancer Discovery
- Prostaglandin E2 Secreted by Thyroid Cancer Cells Contributes to Immune Escape Through the Suppression of Natural Killer (NK) Cell Cytotoxicity and NK Cell Differentiation
- (2018) Arum Park et al. Frontiers in Immunology
- Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity
- (2018) Marte Fauskanger et al. Frontiers in Immunology
- Cancer Neoantigens
- (2018) Ton N. Schumacher et al. Annual Review of Immunology
- Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells
- (2018) Pascale André et al. CELL
- Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma
- (2018) Christof C. Smith et al. JOURNAL OF CLINICAL INVESTIGATION
- T-Cell–Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028
- (2018) Patrick A. Ott et al. JOURNAL OF CLINICAL ONCOLOGY
- Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial
- (2018) Frank Stephen Hodi et al. LANCET ONCOLOGY
- Accounting for proximal variants improves neoantigen prediction
- (2018) Jasreet Hundal et al. NATURE GENETICS
- Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides
- (2018) Rodrigo Prado Martins et al. NUCLEIC ACIDS RESEARCH
- Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy
- (2018) Razvan Cristescu et al. SCIENCE
- Noncoding regions are the main source of targetable tumor-specific antigens
- (2018) Céline M. Laumont et al. Science Translational Medicine
- Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours
- (2018) Aurélie Durgeau et al. Nature Communications
- CD16+NKG2Ahigh Natural Killer Cells Infiltrate Breast Cancer–Draining Lymph Nodes
- (2018) Alexandra Frazao et al. Cancer Immunology Research
- Mapping the MHC Class I–Spliced Immunopeptidome of Cancer Cells
- (2018) Juliane Liepe et al. Cancer Immunology Research
- High-Throughput Stability Screening of Neoantigen/HLA Complexes Improves Immunogenicity Predictions
- (2018) Dylan T. Blaha et al. Cancer Immunology Research
- Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients
- (2018) Hansol Lee et al. OncoImmunology
- IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade
- (2017) Mark Ayers et al. JOURNAL OF CLINICAL INVESTIGATION
- NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data
- (2017) Vanessa Jurtz et al. JOURNAL OF IMMUNOLOGY
- Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)
- (2017) Jacob Schachter et al. LANCET
- Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis
- (2017) Samra Turajlic et al. LANCET ONCOLOGY
- Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers
- (2017) Aaron M. Goodman et al. MOLECULAR CANCER THERAPEUTICS
- Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
- (2017) Ugur Sahin et al. NATURE
- Identification of essential genes for cancer immunotherapy
- (2017) Shashank J. Patel et al. NATURE
- In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
- (2017) Robert T. Manguso et al. NATURE
- An immunogenic personal neoantigen vaccine for patients with melanoma
- (2017) Patrick A. Ott et al. NATURE
- Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
- (2017) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- First-Line Nivolumab in Stage IV or Recurrent Non–Small-Cell Lung Cancer
- (2017) David P. Carbone et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tumor Mutational Burden and Response Rate to PD-1 Inhibition
- (2017) Mark Yarchoan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
- (2017) Sanja Stevanović et al. SCIENCE
- Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
- (2017) Diego Chowell et al. SCIENCE
- Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
- (2017) V. Gopalakrishnan et al. SCIENCE
- Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
- (2017) Bertrand Routy et al. SCIENCE
- Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
- (2017) Whijae Roh et al. Science Translational Medicine
- Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
- (2017) Antje Sucker et al. Nature Communications
- Resistance to checkpoint blockade therapy through inactivation of antigen presentation
- (2017) Moshe Sade-Feldman et al. Nature Communications
- Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
- (2017) Scott Gettinger et al. Cancer Discovery
- The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy
- (2017) Daniel Zingg et al. Cell Reports
- Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
- (2017) Angel Garcia-Diaz et al. Cell Reports
- Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
- (2017) Zachary R. Chalmers et al. Genome Medicine
- Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
- (2017) Alexandre Reuben et al. npj Genomic Medicine
- Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma
- (2017) Cathrin Ritter et al. Scientific Reports
- Pro- and anti-tumour effects of B cells and antibodies in cancer: a comparison of clinical studies and preclinical models
- (2016) Thomas V. Guy et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt/β-catenin signaling pathway
- (2016) Yun-yun Peng et al. CANCER LETTERS
- Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy
- (2016) Xiaohong Wang et al. CANCER RESEARCH
- Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
- (2016) Jianjun Gao et al. CELL
- Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade
- (2016) Joseph L. Benci et al. CELL
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
- (2016) Willy Hugo et al. CELL
- Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response
- (2016) M. I. E. van Poelgeest et al. CLINICAL CANCER RESEARCH
- Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen
- (2016) Elena Shklovskaya et al. IMMUNOLOGY AND CELL BIOLOGY
- TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors
- (2016) Elien M. Doorduijn et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor immune profiling predicts response to anti–PD-1 therapy in human melanoma
- (2016) Adil I. Daud et al. JOURNAL OF CLINICAL INVESTIGATION
- NK Cells Restrain Spontaneous Antitumor CD8+T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells
- (2016) Ximena L. Raffo Iraolagoitia et al. JOURNAL OF IMMUNOLOGY
- Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
- (2016) Jonathan E Rosenberg et al. LANCET
- Neoantigen landscape dynamics during human melanoma–T cell interactions
- (2016) Els M. E. Verdegaal et al. NATURE
- T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
- (2016) Eric Tran et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
- (2016) Martin Reck et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
- (2016) Jesse M. Zaretsky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia Molecules
- (2016) Claudia Prevosto et al. PLoS One
- NLRC5/MHC class I transactivator is a target for immune evasion in cancer
- (2016) Sayuri Yoshihama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Classification and characterization of human endogenous retroviruses; mosaic forms are common
- (2016) Laura Vargiu et al. Retrovirology
- Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
- (2016) N. McGranahan et al. SCIENCE
- Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia
- (2016) Rizwan Romee et al. Science Translational Medicine
- NLRC5 promotes cell proliferation via regulating the AKT/VEGF-A signaling pathway in hepatocellular carcinoma
- (2016) Ying-hua He et al. TOXICOLOGY
- Reprogramming the immunological microenvironment through radiation and targeting Axl
- (2016) Todd A. Aguilera et al. Nature Communications
- Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy
- (2016) Douglas B. Johnson et al. Nature Communications
- Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
- (2016) Michal Bassani-Sternberg et al. Nature Communications
- Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade
- (2016) P.-L. Chen et al. Cancer Discovery
- Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations
- (2016) Daniel Sanghoon Shin et al. Cancer Discovery
- Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity
- (2016) Thomas V. Guy et al. Oncotarget
- Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display
- (2016) Anders Tveita et al. Oncotarget
- pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens
- (2016) Jasreet Hundal et al. Genome Medicine
- Licensed and Unlicensed NK Cells: Differential Roles in Cancer and Viral Control
- (2016) Megan M. Tu et al. Frontiers in Immunology
- Serum Immunoregulatory Proteins as Predictors of Overall Survival of Metastatic Melanoma Patients Treated with Ipilimumab
- (2015) Y. Koguchi et al. CANCER RESEARCH
- Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
- (2015) Michael S. Rooney et al. CELL
- The Clinical Significance of Abnormal Tim-3 Expression on NK Cells from Patients with Gastric Cancer
- (2015) Zhenxin Wang et al. IMMUNOLOGICAL INVESTIGATIONS
- Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells
- (2015) Alessandra Zingoni et al. JOURNAL OF IMMUNOLOGY
- Idiotype-specific CD4+ T cells eradicate disseminated myeloma
- (2015) O A Haabeth et al. LEUKEMIA
- TGF-β and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells
- (2015) Xiao-Hui Chen et al. MOLECULAR IMMUNOLOGY
- Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation
- (2015) K.V. Woan et al. Molecular Oncology
- Mutant MHC class II epitopes drive therapeutic immune responses to cancer
- (2015) Sebastian Kreiter et al. NATURE
- Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
- (2015) Christina Twyman-Saint Victor et al. NATURE
- Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes
- (2015) Sachet A Shukla et al. NATURE BIOTECHNOLOGY
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- (2015) Dung T. Le et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer
- (2015) Julie Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer
- (2015) Hossein Borghaei et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
- (2015) Robert J. Motzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
- (2015) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- LYRA, a webserver for lymphocyte receptor structural modeling
- (2015) Michael Schantz Klausen et al. NUCLEIC ACIDS RESEARCH
- Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
- (2015) E. M. Van Allen et al. SCIENCE
- Neoantigens in cancer immunotherapy
- (2015) T. N. Schumacher et al. SCIENCE
- Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
- (2015) N. A. Rizvi et al. SCIENCE
- The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors
- (2015) Daniel Zingg et al. Nature Communications
- NLRC5 Exclusively Transactivates MHC Class I and Related Genes through a Distinctive SXY Module
- (2015) Kristina Ludigs et al. PLoS Genetics
- BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma
- (2015) S. D. Bradley et al. Cancer Immunology Research
- Matrix metallopeptidase 2 (MMP2) media la eliminación de MHC class I polypeptide-related sequence A (MICA) en el cáncer de células renales
- (2014) F.Q. Yang et al. Actas Urologicas Espanolas
- OptiType: precision HLA typing from next-generation sequencing data
- (2014) András Szolek et al. BIOINFORMATICS
- Cutting Edge: The Metalloproteinase ADAM17/TNF- -Converting Enzyme Regulates Proteolytic Shedding of the MHC Class I-Related Chain B Protein
- (2014) P. Boutet et al. JOURNAL OF IMMUNOLOGY
- Decreased expression of NKG2D, NKp46, DNAM-1 receptors, and intracellular perforin and STAT-1 effector molecules in NK cells and their dim and bright subsets in metastatic melanoma patients
- (2014) Katarina M. Mirjačić Martinović et al. MELANOMA RESEARCH
- MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
- (2014) Thomas Powles et al. NATURE
- PD-1 blockade induces responses by inhibiting adaptive immune resistance
- (2014) Paul C. Tumeh et al. NATURE
- High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
- (2014) Carsten Linnemann et al. NATURE MEDICINE
- Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
- (2014) Alexandra Snyder et al. NEW ENGLAND JOURNAL OF MEDICINE
- TGF- -inducible microRNA-183 silences tumor-associated natural killer cells
- (2014) S. S. Donatelli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer
- (2014) E. Tran et al. SCIENCE
- Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response
- (2014) P. Kvistborg et al. Science Translational Medicine
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- (2014) Viswanath Gunda et al. THYROID
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- (2014) Deepa Kolaseri Krishnadas et al. TUMOR BIOLOGY
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- (2014) I. P. da Silva et al. Cancer Immunology Research
- HLA-E: A Novel Player for Histocompatibility
- (2014) Thomas Kraemer et al. Journal of Immunology Research
- Cancer testis antigens and NY-BR-1 expression in primary breast cancer: prognostic and therapeutic implications
- (2013) Dimitrios Balafoutas et al. BMC CANCER
- Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin
- (2013) R. Remark et al. CLINICAL CANCER RESEARCH
- Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: Heterogeneous involvement of the “a disintegrin and metalloproteases” 10 and 17
- (2013) Guranda Chitadze et al. INTERNATIONAL JOURNAL OF CANCER
- Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma
- (2013) Nienke van Rooij et al. JOURNAL OF CLINICAL ONCOLOGY
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
- (2013) Tyler R. Simpson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- T-helper-1-cell cytokines drive cancer into senescence
- (2013) Heidi Braumüller et al. NATURE
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
- (2013) Paul F Robbins et al. NATURE MEDICINE
- Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
- (2012) L. C. Ndhlovu et al. BLOOD
- Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes
- (2012) Monica Bernal et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens
- (2012) Yikun Yao et al. CELL RESEARCH
- Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice
- (2012) Yanzheng Tong et al. CELL RESEARCH
- CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27- Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian Cancer
- (2012) J. S. Nielsen et al. CLINICAL CANCER RESEARCH
- The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation
- (2012) Florencia Cano et al. EMBO JOURNAL
- Human microRNA-1245 down-regulates the NKG2D receptor in natural killer cells and impairs NKG2D-mediated functions
- (2012) J. L. Espinoza et al. HAEMATOLOGICA
- Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins
- (2012) Gregory R. Robbins et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Induction of tumoricidal function in CD4+T cells is associated with concomitant memory and terminally differentiated phenotype
- (2012) Daniel Hirschhorn-Cymerman et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2012) F. Staehli et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator
- (2012) A. Biswas et al. JOURNAL OF IMMUNOLOGY
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- Landscape of transcription in human cells
- (2012) Sarah Djebali et al. NATURE
- Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status
- (2011) J Šímová et al. BRITISH JOURNAL OF CANCER
- Prognostic impact of B-cell density in cutaneous melanoma
- (2011) Andrea Ladányi et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma
- (2011) S. Platonova et al. CANCER RESEARCH
- White Paper on Adoptive Cell Therapy for Cancer with Tumor-Infiltrating Lymphocytes: A Report of the CTEP Subcommittee on Adoptive Cell Therapy
- (2011) J. Weber et al. CLINICAL CANCER RESEARCH
- Association between natural killer cells and regression in melanocytic lesions
- (2011) Kristopher McKay et al. HUMAN PATHOLOGY
- Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity
- (2011) Emilie Mamessier et al. JOURNAL OF CLINICAL INVESTIGATION
- Cutting Edge: CD8+ T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses
- (2011) K. Soderquest et al. JOURNAL OF IMMUNOLOGY
- CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells To Program Cytotoxic Th1 Differentiation
- (2011) H. Z. Qui et al. JOURNAL OF IMMUNOLOGY
- The escape of cancer from T lymphocytes: immunoselection of MHC class I loss variants harboring structural-irreversible “hard” lesions
- (2010) Federico Garrido et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors
- (2010) Isabel Maleno et al. IMMUNOGENETICS
- Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment
- (2010) Nathalie T. Joncker et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Bystander killing of cancer requires the cooperation of CD4+and CD8+T cells during the effector phase
- (2010) Andrea Schietinger et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Naive tumor-specific CD4+T cells differentiated in vivo eradicate established melanoma
- (2010) Ying Xie et al. JOURNAL OF EXPERIMENTAL MEDICINE
- MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment
- (2010) Julie M. Elliott et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
- (2010) Sergio A. Quezada et al. JOURNAL OF EXPERIMENTAL MEDICINE
- T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis
- (2010) Maria R Parkhurst et al. MOLECULAR THERAPY
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- NLR family member NLRC5 is a transcriptional regulator of MHC class I genes
- (2010) T. B. Meissner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distribution of immune cells in head and neck cancer: CD8+ T-cells and CD20+B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma
- (2009) Dominik Pretscher et al. BMC CANCER
- NK-Dependent Increases in CCL22 Secretion Selectively Recruits Regulatory T Cells to the Tumor Microenvironment
- (2009) A. W. Mailloux et al. JOURNAL OF IMMUNOLOGY
- Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia
- (2009) Gemma G. Kenter et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ocular and Systemic Autoimmunity after Successful Tumor-Infiltrating Lymphocyte Immunotherapy for Recurrent, Metastatic Melanoma
- (2009) Steven Yeh et al. OPHTHALMOLOGY
- Hypermethylation of HLA class I gene is associated with HLA class I down-regulation in human gastric cancer
- (2009) Q. Ye et al. TISSUE ANTIGENS
- Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells
- (2008) M. R. Parkhurst et al. CLINICAL CANCER RESEARCH
- NetMHCpan, a method for MHC class I binding prediction beyond humans
- (2008) Ilka Hoof et al. IMMUNOGENETICS
- The DNA demethylating agent 5-aza-2′-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma
- (2008) Atsushi Natsume et al. INTERNATIONAL JOURNAL OF CANCER
- HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance
- (2008) M Campoli et al. ONCOGENE
- MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma
- (2008) M. Jinushi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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