Article
Biology
Hina Qayoom, Mustfa Alkhanani, Abdullah Almilaibary, Suliman A. Alsagaby, Manzoor Ahmad Mir
Summary: Breast cancer is the leading cause of death among women worldwide, and there is an urgent need for more effective treatment options. A natural compound called Juglanthraquinone C has shown promising potential in treating breast cancer. Through the use of network pharmacology techniques, this study investigated the molecular mechanism of Juglanthraquinone C in breast cancer and identified common targets and pathways. The findings highlight the significance of Juglanthraquinone C as a potential treatment for breast cancer and provide insights into its molecular mechanism.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Medicine, Research & Experimental
Harshini Mallipeddi, Anita Thyagarajan, Ravi P. Sahu
Summary: The natural compound Withaferin-A has shown promising anti-tumoral activities against TNBC in both in-vitro and in-vivo experimental models, with studies indicating its potential to enhance chemotherapy efficacy. Derived from the ayurvedic medicinal plant Withania somnifera, Withaferin-A demonstrates anti-inflammatory and anti-cancer properties, highlighting its significance in the treatment of TNBC.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Eun-Ryeong Hahm, Su-Hyeong Kim, Krishna B. Singh, Shivendra Singh
Summary: The study revealed that Withaferin A (WA) may prevent breast cancer by downregulating genes associated with cellular senescence, upregulating p21, affecting cellular response to stress, and decreasing glycolysis-related proteins. Additionally, NRF2 knockout cells were found to be more resistant to WA-induced apoptosis, suggesting a potential mechanism for WA's chemopreventive efficacy in breast cancer.
MOLECULAR CARCINOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Eun-Ryeong Hahm, Su-Hyeong Kim, Shivendra V. Singh
Summary: Bone is a common site for breast cancer metastasis, leading to complications such as pain and fractures. Current treatments have limitations, thus a safe and effective agent for preventing bone metastasis is urgently needed. Withaferin A (WA), derived from Withania somnifera, has been shown to downregulate genes involved in bone remodeling and breast cancer metastasis. In this study, WA was found to inhibit osteoclast differentiation induced by different breast cancer subtypes, accompanied by suppression of key osteoclastogenic cytokines. Additionally, WA decreased the expression of transcription factors associated with osteoclastogenesis. These findings suggest that WA could be a promising agent for preventing breast cancer-induced bone metastasis.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Kumari Sunita Prajapati, Mohd. Shuaib, Sanjay Gupta, Shashank Kumar
Summary: Breast cancer is a heterogeneous disease, and WA inhibits the proliferation and stemness of breast cancer cells by modulating miRNA expression, thereby inhibiting mammosphere formation.
MOLECULAR CARCINOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Yunshan Zhang, Zhuomin Zhang, Hui Liu, De Wang, Jiahui Wang, Meng Liu, Yanjing Yang, Shian Zhong
Summary: This study characterized the chain structure of selenium polysaccharide (Se-POP-3) and investigated its anti-gastric cancer and anti-colon cancer effects. Results showed that Se-POP-3 had inhibitory effects on cancer cells and no significant effect on normal cells. This study provides a theoretical basis for the potential application of Se-POP-3 as an anti-gastrointestinal cancer drug or functional food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Tobias Fischer, Jonas Leitner, Aaron Gerwien, Peter Mayer, Andreas Dreuw, Henry Dube, Josef Wachtveitl
Summary: The Hula-Twist (HT) photoreaction, which involves the motion of a double bond and an adjacent single bond, is a fundamental pathway for bond isomerizations. However, the fleeting nature of HT photoproducts has hindered direct experimental observation of this coupled motion. In this study, the Dube group designed a molecular framework using sterically crowded atropisomeric hemithioindigo (HTI) to stabilize the HT photoproducts and enable their direct observation. Furthermore, the researchers investigated the ultrafast excited state processes of the HT photoreaction, providing important insights into the mechanism of complex multibond rotations in the excited state.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Maushma Atteeq
Summary: Withaferin A, derived from the plant Withania somnifera, has gained great attention for its anticancer properties. It interacts with key proteins involved in cancer cell activity, leading to apoptosis. Additionally, Withaferin A generates reactive oxidative species, activates Par-4, induces endoplasmic reticulum stress, and activates p53, contributing to its pro-apoptotic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tahira Sultana, Mohammad K. Okla, Madiha Ahmed, Nosheen Akhtar, Abdulrahman Al-Hashimi, Hamada Abdelgawad, Ihsan-ul- Haq
Summary: Withaferin A is a pivotal withanolide with multifaceted mechanisms and a broad spectrum of pharmacological profiles, including anticancer and anti-inflammatory properties. It holds potential for integrative cancer chemoprevention and cure, highlighting the importance of advancing it to clinical trials for commercial drug use.
Article
Chemistry, Physical
Lukas A. Wolzak, Joen J. Hermans, Folkert de Vries, Keimpe J. van den Berg, Joost N. H. Reek, Moniek Tromp, Ties J. Korstanje
Summary: Studies found that under catalytically relevant conditions only monomeric n-butyltin(IV) carboxylates and dimeric species are present, while Density Functional Theory calculations support a mononuclear mechanism with carbon-oxygen bond breaking as the rate-determining step.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Aisling L. Ryan, Joshua Northcote-Smith, Aoife McKeon, Andrew Roe, Paul O'Dowd, Brendan Twamley, Triona Ni Chonghaile, Kogularamanan Suntharalingam, Darren M. Griffith
Summary: The first example of a Pt complex of GANT61, a hedgehog (Hh) pathway inhibitor, is reported. The complex showed potent inhibition activity against breast CSC cells and triple negative breast cancer cells, as well as significant inhibition effect on the CSC-enriched mammosphere model.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Long Xiao, Yu Huang, Yuhe Yang, Zhiwei Miao, Jie Zhu, Mengdan Zhong, Chencheng Feng, Wenkai Tang, Jinhua Zhou, Lihong Wang, Xin Zhao, Zhirong Wang
Summary: The researchers have developed a biomimetic cytomembrane cancer nanovaccine named CCMP@R837, which enhanced the immune response against breast cancer cells and established immune memory in BALB/c mice. This vaccine platform shows potential as a candidate for preventive cancer vaccines in clinical settings.
Review
Chemistry, Applied
Theebaa Anasamy, Chin Fei Chee, Yuen Fei Wong, Choon Han Heh, Lik Voon Kiew, Hong Boon Lee, Lip Yong Chung
Summary: This review discusses recent in vitro and in vivo mechanistic studies of triorganotin complexes from 2007 to 2019, and elaborates on potential mechanisms that could aid in identifying molecular targets of triorganotin complexes.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Review
Oncology
Cosmos Ifeanyi Onyiba, Christopher J. Scarlett, Judith Weidenhofer
Summary: This review discusses the role of SIRT1-7 genes and proteins in breast and prostate cancers, highlighting their involvement in various processes such as proliferation, apoptosis, and metastasis. The review also presents evidence of the regulation of SIRT1-7 by miRNAs and emphasizes the potential value of SIRT1-7 as biomarkers and targets for improved treatment of breast and prostate cancers.
Review
Medicine, Research & Experimental
YingZheng Wang, Tong Wang, HuaXin Wang, WeiDong Liu, Xiao Li, XiaoYan Wang, YaNan Zhang
Summary: The antitumor effects of traditional drugs have received attention and active antitumor components extracted from traditional drugs have shown good efficacy. Cepharanthine (CEP) is an active component derived from Stephania plants that can inhibit tumor progression through multiple signaling pathways. By summarizing recent studies on CEP's antitumor effects and mechanism, this review aims to provide new insights and a theoretical basis for further development and application of CEP.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Dimiter B. Avtanski, Arumugam Nagalingam, Panjamurthy Kuppusamy, Michael Y. Bonner, Jack L. Arbiser, Neeraj K. Saxena, Dipali Sharma
Article
Biochemistry & Molecular Biology
Anan H. Said, Shien Hu, Ameer Abutaleb, Tonya Watkins, Kunrong Cheng, Ahmed Chahdi, Panjamurthy Kuppusamy, Neeraj Saxena, Guofeng Xie, Jean-Pierre Raufman
BIOCHEMICAL JOURNAL
(2017)
Article
Biochemistry & Molecular Biology
S. Sengupta, A. Nagalingam, N. Muniraj, M. Y. Bonner, P. Mistriotis, A. Afthinos, P. Kuppusamy, D. Lanoue, S. Cho, P. Korangath, M. Shriver, A. Begum, V. F. Merino, C-Y Huang, J. L. Arbiser, W. Matsui, B. Gyorffy, K. Konstantopoulos, S. Sukumar, P. A. Marignani, N. K. Saxena, D. Sharma
Article
Multidisciplinary Sciences
Panjamurthy Kuppusamy, Arumugam Nagalingam, Nethaji Muniraj, Neeraj K. Saxena, Dipali Sharma
SCIENTIFIC REPORTS
(2017)
Article
Biochemical Research Methods
Vedagopuram Sreekanth, Sandhya Bansal, Rajender K. Motiani, Somanath Kundu, Sravan Kumar Muppu, Tapodhara Datta Majumdar, Kuppusamy Panjamurthy, Sagar Sengupta, Avinash Bajaj
BIOCONJUGATE CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Subhas S. Karki, Kuppusamy Panjamurthy, Sujeet Kumar, Mridula Nambiar, Sureshbabu A. Ramareddy, Kishore K. Chiruvella, Sathees C. Raghavan
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2011)
Article
Oncology
Kuppusamy Panjamurthy, Shanmugam Manoharan, Madhavan Ramados Nirmal, Lakshmanan Vellaichamy
INVESTIGATIONAL NEW DRUGS
(2009)
Article
Biochemistry & Molecular Biology
Sheetal Sharma, Kuppusamy Panjamurthy, Bibha Choudhary, Mrinal Srivastava, M. S. Shahabuddin, Ranjit Giri, Gopal M. Advirao, Sathees C. Raghavan
MOLECULAR CARCINOGENESIS
(2013)
Article
Biochemistry & Molecular Biology
Madhusudan N. Purohit, Kuppusamy Panjamurthy, Santhini Elango, Karteek Hebbar, Yergeri C. Mayur, Sathees C. Raghavan
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2011)
Article
Multidisciplinary Sciences
Mahesh Hegde, Subhas S. Karki, Elizabeth Thomas, Sujeet Kumar, Kuppusamy Panjamurthy, Somasagara R. Ranganatha, Kanchugarakoppal S. Rangappa, Bibha Choudhary, Sathees C. Raghavan
Article
Multidisciplinary Sciences
Bei Xie, Arumugam Nagalingam, Panjamurthy Kuppusamy, Nethaji Muniraj, Peter Langford, Balazs Gyorffy, Neeraj K. Saxena, Dipali Sharma
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Arumugam Nagalingam, Sumit Siddharth, Sheetal Parida, Nethaji Muniraj, Dimiter Avtanski, Panjamurthy Kuppusamy, Justin Elsey, Jack L. Arbiser, Balazs Gyorffy, Dipali Sharma
Summary: The study reveals the molecular mechanisms by which obesity/hyperleptinemia reduces the efficacy of hormonal therapy, involving leptin-induced Med1 expression, miR205 regulation, and activation of Her2 and EGFR. In a hyperleptinemic state, honokiol and adiponectin can effectively inhibit leptin's negative effects on tamoxifen.
Article
Cell Biology
Seung J. Chung, Ganji Purnachandra Nagaraju, Arumugam Nagalingam, Nethaji Muniraj, Panjamurthy Kuppusamy, Alyssa Walker, Juhyung Woo, Balazs Gyorffy, Ed Gabrielson, Neeraj K. Saxena, Dipali Sharma
Article
Biology
S. Manoharan, K. Panjamurthy, Venugopal P. Menon, S. Balakrishnan, Linsa Mary Alias
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2009)