A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control

Human TCR That Incorporate CD3  Induce Highly Preferred Pairing between TCR  and   Chains following Gene Transfer

(2014) Z. Sebestyen et al.   JOURNAL OF IMMUNOLOGY

Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions

(2014) Paul F. Robbins et al.   JOURNAL OF IMMUNOLOGY

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

(2013) J. N. Kochenderfer et al.   BLOOD

Relapse or Eradication of Cancer Is Predicted by Peptide-Major Histocompatibility Complex Affinity

(2013) Boris Engels et al.   CANCER CELL

A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells

(2013) Jun Huang et al.   IMMUNITY

Exploiting the curative potential of adoptive T-cell therapy for cancer

(2013) Christian S. Hinrichs et al.   IMMUNOLOGICAL REVIEWS

Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy

(2013) Richard A. Morgan et al.   JOURNAL OF IMMUNOTHERAPY

Plasticity in the Contribution of T Cell Receptor Variable Region Residues to Binding of Peptide–HLA-A2 Complexes

(2013) Sheena N. Smith et al.   JOURNAL OF MOLECULAR BIOLOGY

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

(2013) Paul F Robbins et al.   NATURE MEDICINE

The Basic Principles of Chimeric Antigen Receptor Design

(2013) Michel Sadelain et al.   Cancer Discovery

An Updated View of the Intracellular Mechanisms Regulating Cross-Presentation

(2013) Priyanka Nair-Gupta et al.   Frontiers in Immunology

MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

(2012) Carolina M. Soto et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

T-cell-receptor-like antibodies – generation, function and applications

(2012) Rony Dahan et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses

(2012) A S Chervin et al.   GENE THERAPY

Long-term Persistence of CD4+ but Rapid Disappearance of CD8+ T Cells Expressing an MHC Class I-restricted TCR of Nanomolar Affinity

(2012) Boris Engels et al.   MOLECULAR THERAPY

A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)

(2012) Jennifer D. Stone et al.   OncoImmunology

Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains

(2011) D H Aggen et al.   GENE THERAPY

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

(2011) Paul F. Robbins et al.   JOURNAL OF CLINICAL ONCOLOGY

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Targeting stroma to treat cancers

(2011) Boris Engels et al.   SEMINARS IN CANCER BIOLOGY

Coexpression of the T-cell receptor constant   domain triggers tumor reactivity of single-chain TCR-transduced human T cells

(2010) R.-H. Voss et al.   BLOOD

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

Transgenic mice with a diverse human T cell antigen receptor repertoire

(2010) Liang-Ping Li et al.   NATURE MEDICINE

Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors

(2010) D. H. Aggen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Different Strategies Adopted by Kband Ldto Generate T Cell Specificity Directed against Their Respective Bound Peptides

(2009) Natalie A. Bowerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Inhibitory Effects of CD4 and CD8 on T Cell Activation Induced by High-Affinity Noncognate Ligands

(2009) A. S. Chervin et al.   JOURNAL OF IMMUNOLOGY

The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness

(2009) A. S. Chervin et al.   JOURNAL OF IMMUNOLOGY

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

(2009) Michael C. Milone et al.   MOLECULAR THERAPY

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

How a T Cell Receptor-like Antibody Recognizes Major Histocompatibility Complex-bound Peptide

(2008) Tatiana Mareeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain VαVβ fragments

(2008) Sarah A. Richman et al.   MOLECULAR IMMUNOLOGY