Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses

Long-term Persistence of CD4+ but Rapid Disappearance of CD8+ T Cells Expressing an MHC Class I-restricted TCR of Nanomolar Affinity

(2012) Boris Engels et al.   MOLECULAR THERAPY

Visualizing the dynamic of adoptively transferred T cells during the rejection of large established tumors

(2011) Jehad Charo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

One naive T cell, multiple fates in CD8+T cell differentiation

(2010) Carmen Gerlach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Of Mice, Not Men: No Evidence for Graft-versus-Host Disease in Humans Receiving T-Cell Receptor–Transduced Autologous T Cells

(2010) Steven A Rosenberg   MOLECULAR THERAPY

Transgenic mice with a diverse human T cell antigen receptor repertoire

(2010) Liang-Ping Li et al.   NATURE MEDICINE

Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses

(2010) R. C. Koya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors

(2010) D. H. Aggen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Attenuated T Cell Responses to a High-Potency Ligand In Vivo

(2010) Emily Corse et al.   PLOS BIOLOGY

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Preclinical development of T cell receptor gene therapy

(2009) Gavin M Bendle et al.   CURRENT OPINION IN IMMUNOLOGY

Adoptive T cell therapy of cancer

(2009) Ton NM Schumacher et al.   CURRENT OPINION IN IMMUNOLOGY

T Cell Receptor Gene Therapy for Cancer

(2009) Thomas M. Schmitt et al.   HUMAN GENE THERAPY

T cells as pioneers: antigen-specific T cells condition inflamed sites for high-rate antigen-non-specific effector cell recruitment

(2009) Saeed Ghani et al.   IMMUNOLOGY

Recurrence of Intracranial Tumors following Adoptive T Cell Therapy Can Be Prevented by Direct and Indirect Killing Aided by High Levels of Tumor Antigen Cross-Presented on Stromal Cells

(2009) D. L. Thomas et al.   JOURNAL OF IMMUNOLOGY

The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness

(2009) A. S. Chervin et al.   JOURNAL OF IMMUNOLOGY

Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity

(2009) Natalie A. Bowerman et al.   MOLECULAR IMMUNOLOGY

Germline-encoded amino acids in the αβ T-cell receptor control thymic selection

(2009) James P. Scott-Browne et al.   NATURE

The molecular basis of TCR germline bias for MHC is surprisingly simple

(2009) K Christopher Garcia et al.   NATURE IMMUNOLOGY

Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

(2008) Philippa Marrack et al.   Annual Review of Immunology

Regulated Expression of a Tumor-Associated Antigen Reveals Multiple Levels of T-Cell Tolerance in a Mouse Model of Lung Cancer

(2008) A. F. Cheung et al.   CANCER RESEARCH

T-cell receptor bias and immunity

(2008) Stephanie Gras et al.   CURRENT OPINION IN IMMUNOLOGY

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Dissecting T cell lineage relationships by cellular barcoding

(2008) Koen Schepers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Engineering higher affinity T cell receptors using a T cell display system

(2008) Adam S. Chervin et al.   JOURNAL OF IMMUNOLOGICAL METHODS