mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels

Caloric restriction: is mammalian life extension linked to p53?

(2016) Paola Tucci   Aging-US

The RP-Mdm2-p53 Pathway and Tumorigenesis

(2015) Paula L. Miliani de Marval et al.   Oncotarget

AKT mediates actinomycin D-induced p53 expression

(2015) Chih-Shou Chen et al.   Oncotarget

Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D

(2014) Małgorzata Krześniak et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors

(2014) Rui Liu et al.   NUCLEIC ACIDS RESEARCH

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast

(2013) Charalampos Rallis et al.   AGING CELL

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

(2013) Giulio Donati et al.   Cell Reports

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Ribosome Biogenesis and Control of Cell Proliferation: p53 Is Not Alone

(2012) G. Donati et al.   CANCER RESEARCH

mTORC1 and p53

(2012) Paul Hasty et al.   CELL CYCLE

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

(2012) S. Fumagalli et al.   GENES & DEVELOPMENT

Dexamethasone Reduces Sensitivity to Cisplatin by Blunting p53-Dependent Cellular Senescence in Non-Small Cell Lung Cancer

(2012) Haiyan Ge et al.   PLoS One

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

(2012) S. Bursac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

(2011) Glenn S. Van Aller et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

The nucleolus directly regulates p53 export and degradation

(2011) Mark T. Boyd et al.   JOURNAL OF CELL BIOLOGY

The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases

(2011) Artur Zajkowicz et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner

(2011) B Mahata et al.   ONCOGENE

The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells

(2011) G Donati et al.   ONCOGENE

Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin

(2011) D. Avitabile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53, Oxidative Stress, and Aging

(2010) Dongping Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy

(2010) Meng Ling Choong et al.   CELL CYCLE

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

(2010) Keng Po Lai et al.   EMBO JOURNAL

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

(2010) Andrea Alimonti et al.   JOURNAL OF CLINICAL INVESTIGATION

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Curcumin Dually Inhibits Both Mammalian Target of Rapamycin and Nuclear Factor- B Pathways through a Crossed Phosphatidylinositol 3-Kinase/Akt/I B Kinase Complex Signaling Axis in Adenoid Cystic Carcinoma

(2010) Z.-J. Sun et al.   MOLECULAR PHARMACOLOGY

The translational response of the human mdm2 gene in HEK293T cells exposed to rapamycin: a role for the 5′-UTRs

(2010) Raphael Genolet et al.   NUCLEIC ACIDS RESEARCH

Essential role of PI3-kinase pathway in p53-mediated transcription: Implications in cancer chemotherapy

(2010) R Suvasini et al.   ONCOGENE

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway

(2010) C Deisenroth et al.   ONCOGENE

Silencing of Ribosomal Protein S9 Elicits a Multitude of Cellular Responses Inhibiting the Growth of Cancer Cells Subsequent to p53 Activation

(2010) Mikael S. Lindström et al.   PLoS One

Resveratrol induces p53 and suppresses myocardin-mediated vascular smooth muscle cell differentiation

(2010) Jian-Pu Zheng et al.   TOXICOLOGY LETTERS

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

(2009) C. S. Beevers et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Regulation of nucleolar signalling to p53 through NEDDylation of L11

(2009) Anders Sundqvist et al.   EMBO REPORTS

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal Compartment

(2009) Z. Feng   Cold Spring Harbor Perspectives in Biology

Mycophenolic Acid Activation of p53 Requires Ribosomal Proteins L5 and L11

(2008) Xiao-Xin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML

(2008) K Kojima et al.   LEUKEMIA

Caffeine extends yeast lifespan by targeting TORC1

(2008) Valeria Wanke et al.   MOLECULAR MICROBIOLOGY