Article
Biochemistry & Molecular Biology
Zifeng Liu, Guiling Zhang, Jing Chen, Jingjing Tong, Hongmin Wang, Dong Yang, Jinhua Hu
Summary: This study found that G-CSF can promote liver cell viability and angiogenesis in injured livers by directly affecting the liver cells through the AKT and ERK signaling pathways. These findings improve our understanding of the role of G-CSF in recovery from liver failure.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Review
Immunology
Remo Poto, Adriana Rosa Gambardella, Gianni Marone, John T. T. Schroeder, Fabrizio Mattei, Giovanna Schiavoni, Gilda Varricchi
Summary: Human basophils, accounting for a small percentage of circulating leukocytes, have been the focus of research in recent years due to their roles in allergic diseases, cancer, and wound healing.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Environmental
Haoxiao Yan, Liulan Zhao, Qishuang He, Yifan Hu, Quanxi Li, Kuo He, Dongmei Zhang, Qiao Liu, Jie Luo, Wei Luo, Shiyi Chen, Lisen Li, Song Yang
Summary: In this study, the researchers investigated the effects of 4 weeks of intermittent hypoxic exposure (IHE) on liver angiogenesis and related regulatory mechanisms in largemouth bass. The findings revealed that IHE reduced the O2 tension for loss of equilibrium and increased the concentrations of red blood cells (RBC) and hemoglobin. The study also identified a correlation between increased angiogenesis and the expression of regulators such as Jagged, phosphoinositide-3-kinase (PI3K), and mitogen-activated protein kinase (MAPK). Additionally, the overexpression of factors related to angiogenesis processes mediated by HIF-independent pathways was associated with lactic acid (LA) accumulation in the liver.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Isabela Gobbo Ferreira, Manuela Berto Pucca, Isadora Sousa de Oliveira, Felipe Augusto Cerni, Beatriz de Cassia da Silva Jacob, Eliane Candiani Arantes
Summary: VEGF is a crucial regulator of angiogenesis in both physiological and pathological conditions. It is categorized into seven families, with different types found in mammals, viruses, and snake venoms. This review focuses on the svVEGF family, exploring its distribution, molecular structure, functions, and potential applications within snake venoms.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Fisheries
Liulan Zhao, Xiaohong Tang, Rui Huang, Qiao Liu, Lei Liao, Yifan Hu, Kuo He, Xin Zhang, Jiazhong Guo, Shiyi Chen, Song Yang
Summary: This study investigated the effect of acute hypoxia on liver angiogenesis in largemouth bass. The results showed that hypoxia exposure promoted angiogenesis occurrence and increased the concentration of vasodilation factors. Hypoxia exposure also up-regulated the expression of certain genes and proteins related to angiogenesis. The findings suggest that acute hypoxia can stimulate liver angiogenesis in largemouth bass through the HIF-dependent pathway.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nadia Calabriso, Eleonora Stanca, Alessio Rochira, Fabrizio Damiano, Laura Giannotti, Benedetta Di Chiara Stanca, Marika Massaro, Egeria Scoditti, Christian Demitri, Paola Nitti, Andrea Palermo, Luisa Siculella, Maria Annunziata Carluccio
Summary: The experimental study found that CGFs contain important pro-angiogenic factors that promote endothelial cell migration, tube structure formation, and the expression of multiple angiogenic mediators by endothelial cells. This suggests that CGFs promote endothelial angiogenesis through their soluble and cellular components, making them a potential biomaterial for therapeutic vasculogenesis in the field of tissue regeneration.
Review
Oncology
Jaume Mora, Shakeel Modak, Joyce Kinsey, Carolyn E. Ragsdale, Hillard M. Lazarus
Summary: Colony-stimulating factors, such as GM-CSF, have been studied extensively for their potential to enhance the effectiveness of anti-GD2 monoclonal antibodies in high-risk neuroblastoma. However, access to these therapies is not uniform, and there is limited clinical data supporting the use of G-CSF as an alternative to GM-CSF. More research is needed to ensure equitable access to these treatments globally.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Barbara Vizio, Ornella Bosco, Ezio David, Gian Paolo Caviglia, Maria Lorena Abate, Martina Schiavello, Angela Pucci, Antonina Smedile, Gianluca Paraluppi, Renato Romagnoli, Enrico Lupia, Graziella Bellone, Giuseppe Montrucchio
Summary: The study revealed that THPO and VEGF-A expression levels were significantly elevated in tumor tissues compared to liver cirrhosis tissues in HCC patients. There was a linear correlation between THPO and VEGF-A transcripts in HCC, indicating a potential interdependent regulation between the two growth factors in promoting cellular growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Man You, Junmin Fu, Xingzhi Lv, Lan Wang, Hongwei Wang, Ruifang Li
Summary: In this study, it was found that Saikosaponin b2 (SSb2), an active component of Radix Bupleuri, exhibited potent antitumor activity by inhibiting tumor angiogenesis. SSb2 effectively inhibited tumor growth with low immunotoxicity in H22 tumor-bearing mice. It also inhibited proliferation and migration of HepG2 liver cancer cells, confirming its antitumor effect. Furthermore, SSb2 significantly inhibited various stages of angiogenesis in vitro, including the proliferation, migration, and invasion of human umbilical vein endothelial cells.
Review
Cell Biology
William Khoury, Ryan Trus, Xingyu Chen, Leili Baghaie, Mira Clark, Myron R. Szewczuk, Mohammad El-Diasty
Summary: Angiogenesis is the process of developing new blood vessels for delivering oxygen and nutrients to growing tissues. Pentoxifylline (PTX) has been used to manage vascular disorders, and its effects on angiogenesis have been studied. While some studies suggest that PTX has an antiangiogenic effect, others show it may have a proangiogenic effect or no effect at all. The mechanisms and clinical implications of PTX in angiogenesis are still unclear.
Article
Dermatology
Ayu Watanabe, Masahiro Kamata, Teruo Shimizu, Hideaki Uchida, Emi Sakurai, Shoya Suzuki, Hideyuki Nakajima, Yoshiko Niimura, Makoto Ito, Shota Egawa, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Yayoi Tada
Summary: This study found that serum levels of certain angiogenesis-related factors in psoriasis patients are abnormal and correlated with the clinical severity and systemic inflammation of the disease. Some of these factors could serve as biomarkers for treatment outcomes and disease severity.
JOURNAL OF DERMATOLOGY
(2022)
Article
Ophthalmology
Wanju Yang, Yanning Yang, Shanshan Wan, Ya Xu, Jing Li, Lu Zhang, Wanruo Guo, Yijun Zheng, Yi Xiang, Yiqiao Xing
Summary: The study revealed that silencing PXN inhibited VEGF-A-induced invasion and angiogenesis of HUVECs through regulation of cell metabolism and mitochondrial damage, suggesting that PXN may be a potential target for antiangiogenic therapies.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Physiology
William S. Evans, Jacob B. Blumenthal, James M. Heilman, Alice S. Ryan, Steven J. Prior
Summary: The study found that aerobic exercise training with weight loss can increase skeletal muscle angiogenic growth factor levels, improve glucose tolerance, and enhance the health of obese older adults with impaired glucose tolerance.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xavier O. Scott, Stephanie H. Chen, Roey Hadad, Dileep Yavagal, Eric C. Peterson, Robert M. Starke, W. Dalton Dietrich, Robert W. Keane, Juan Pablo de Rivero Vaccari
Summary: In this study, the differential expression of angiogenic and inflammatory factors in thrombi, cerebral plasma, and peripheral plasma of stroke patients was evaluated. The results showed that these factors varied significantly in different compartments, highlighting the importance of identifying new biomarkers for the diagnosis and treatment of stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Oncology
Johanna A. A. Bult, Jessica R. Placa, Erlin A. Haacke, M. Martijn Terpstra, Gwenny M. Verstappen, Frederik K. L. Spijkervet, Frans G. M. Kroese, Wouter J. Plattel, Joost S. P. Vermaat, Hendrika Bootsma, Bert van der Vegt, Arjan Diepstra, Anke van den Berg, Klaas Kok, Marcel Nijland
Summary: This study investigated the genomic characteristics of parotid gland-associated mucosa-associated lymphoid tissue (MALT) extranodal marginal zone lymphoma (ENMZL) in primary Sjogren's syndrome (pSS). The findings showed that pSS-associated MALT lymphomas have a low mutational load and limited copy number alterations, suggesting that they are genomically stable and may depend on a stimulatory micro-environment.
Article
Hematology
Mirian Brink, Frederik O. Meeuwes, Marjolein W. M. van der Poel, Marie Jose Kersten, Marielle Wondergem, Pim G. N. J. Mutsaers, Lara H. Bohmer, F. J. Sherida H. Woei-A-Jin, Otto Visser, Rimke Oostvogels, Patty M. Jansen, Wouter Plattel, Gerwin A. Huls, Joost S. P. Vermaat, Marcel Nijland
Summary: In patients aged <65 years with PTCL, the addition of etoposide and consolidation with ASCT improved overall survival rates, particularly in ALK(+) ALCL patients. ASCT consolidation was associated with improved survival rates in patients with ALCL, AITL, or PTCL, while the addition of etoposide did not show significant correlation with survival rates.
Review
Oncology
Fleur A. de Groot, Ruben A. L. de Groen, Anke van den Berg, Patty M. Jansen, King H. Lam, Pim G. N. J. Mutsaers, Carel J. M. van Noesel, Martine E. D. Chamuleau, Wendy B. C. Stevens, Jessica R. Placa, Rogier Mous, Marie Jose Kersten, Marjolein M. W. van der Poel, Thomas Tousseyn, F. J. Sherida H. Woei-a-Jin, Arjan Diepstra, Marcel Nijland, Joost S. P. Vermaat
Summary: This review summarizes the insights from gene-expression profiling studies on the background and origination of diffuse large B-cell lymphomas (DLBCL). By combining transcriptomics with genomics, proteomics, and patient characteristics, diagnostic classification, prognostication, and the development of new targeted therapeutic strategies in DLBCL can be improved.
Meeting Abstract
Oncology
S. Postel-Vinay, A. Italiano, P. Martin Romano, P. A. Cassier, L. L. Siu, I. S. Lossos, J. F. Hilton, M. A. Mckean, J. Strauss, G. S. Falchook, M. J. A. de Jonge, F. L. Opdam, D. Rasco, J. S. Vermaat, T. Crossman, M. Zajac, A. Hainline, B. Kremer, O. Barbash, M. M. Gounder
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Frederik O. Meeuwes, Mirian Brink, Marjolein W. M. Van Der Poel, Marie Jose Kersten, Marielle Wondergem, Pim G. N. J. Mutsaers, Lara Bohmer, Sherida Woei-A-Jin, Otto Visser, Rimke Oostvogels, Patty M. Jansen, Arjan Diepstra, Tjeerd J. F. Snijders, Wouter J. Plattel, Gerwin A. Huls, Joost S. P. Vermaat, Marcel Nijland
Summary: Although rituximab improved overall response rate (ORR) for patients with AITL, there was no significant impact on progression-free survival (PFS) and overall survival (OS).
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Ziva Pogacar, Jackie L. Johnson, Lenno Krenning, Giulia De Conti, Fleur Jochems, Cor Lieftink, Arno Velds, Leyma Wardak, Kelvin Groot, Arnout Schepers, Liqin Wang, Ji-Ying Song, Marieke van de Ven, Olaf van Tellingen, Rene H. Medema, Roderick L. Beijersbergen, Rene Bernards, Rodrigo Leite de Oliveira
Summary: This study found that the use of the CDK2 inhibitor, indisulam, can enhance the induction of senescence in cancer cells by the CDK4/6 inhibitor, palbociclib, and sensitize the cells to senolytic therapy.
Editorial Material
Oncology
Eric Solary, Patricia Blanc, Michael Boutros, Charis Girvalaki, Franco Locatelli, Rene H. Medema, Peter Nagy, Josep Tabernero
Summary: UNCAN.eu is a European initiative aimed at advancing cancer research through the creation of a research data hub, leading to new developments in cancer care.
Correction
Oncology
Maud Kamal, Sonia Lameiras, Marc Deloger, Adeline Morel, Sophie Vacher, Charlotte Lecerf, Celia Dupain, Emmanuelle Jeannot, Elodie Girard, Sylvain Baulande, Coraline Dubot, Gemma Kenter, Ekaterina Jordanova, Els M. J. J. Berns, Guillaume Bataillon, Marina Popovic, Roman Rouzier, Wulfran Cacheux, Christophe Le Tourneau, Alain Nicolas, Nicolas Servant, Suzy Scholl, Ivan Bieche, RAIDs Consortium
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Claire Vennin, Chiara M. Cattaneo, Leontien Bosch, Serena Vegna, Xuhui Ma, Hugo G. J. Damstra, Moreno Martinovic, Efi Tsouri, Mila Ilic, Leyla Azarang, Jan R. T. van Weering, Emilia Pulver, Amber L. Zeeman, Tim Schelfhorst, Jeroen O. Lohuis, Anne C. Rios, Johanna F. Dekkers, Leila Akkari, Renee Menezes, Rene Medema, Serena R. Baglio, Anna Akhmanova, Sabine C. Linn, Simone Lemeer, Dirk M. Pegtel, Emile E. Voest, Jacco van Rheenen
Summary: Although treatment with taxanes may not always be effective, it carries the risk of side effects like peripheral neuropathy. A study found that taxanes can directly stimulate T cells to selectively kill cancer cells, independent of the T cell receptor. This mechanism involves the release of cytotoxic extracellular vesicles by T cells, inducing apoptosis specifically in tumor cells. These findings were utilized to develop a therapeutic approach using pre-treated T cells, avoiding systemic toxicity.
Article
Oncology
Lisa Koob, Anoek Friskes, Louise van Bergen, Femke M. Feringa, Bram van den Broek, Emma S. Koeleman, Ellis van Beek, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, Rene H. Medema
Summary: This study demonstrates that the meiotic recombination co-factor MND1 plays a role in the repair of DNA double-strand breaks (DSBs) in somatic cells. MND1 localizes to DSBs and stimulates DNA repair through homologous recombination (HR). Importantly, MND1 specifically functions in the repair response to two-ended DSBs induced by irradiation (IR) or chemotherapeutic drugs, and its activity is primarily observed in the G2 phase.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
A. Vera de Jonge, Erik van Werkhoven, Avinash G. Dinmohamed, Marcel Nijland, Aeilko H. Zwinderman, Patrick M. Bossuyt, Martine S. Veldhuis, Emma G. G. M. Rutten, Rogier Mous, Joost S. P. Vermaat, Yorick Sandberg, Eva de Jongh, Yavuz M. Bilgin, Rinske Boersma, Harry Koene, Marie Jose Kersten, Daphne de Jong, Martine E. D. Chamuleau
Summary: In a study conducted in the Netherlands, researchers found that R2CHOP treatment significantly improved the prognosis of DLBCL patients compared to R-CHOP treatment, based on a non-randomized risk-adjusted comparison.
BLOOD CANCER JOURNAL
(2023)
Article
Oncology
Johanna A. A. Bult, Francien Huisman, Yujie Zhong, Nick Veltmaat, Joost Kluiver, Sanne H. Tonino, Joost S. P. Vermaat, Martine E. D. Chamuleau, Arjan Diepstra, Anke van den Berg, Wouter J. Plattel, Mirian Brink, Marcel Nijland
Summary: This population-based study reveals the clinical characteristics associated with transformation and survival after transformation of marginal zone lymphoma (tMZL). Elevated LDH and nodal MZL subtype at MZL diagnosis increase the risk of transformation, while radiotherapy reduces the risk. Age >60 years and (immuno)chemotherapy before transformation are associated with an increased risk of relapse and mortality. Two-year progression-free survival and overall survival are higher for R-(mini)CHOP-treated tMZL patients.
BLOOD CANCER JOURNAL
(2023)
Article
Cell Biology
Anna G. Manjon, Stefano Giustino Manzo, Stefan Prekovic, Leon Potgeter, Tom van Schaik, Ning Qing Liu, Koen Flach, Daniel Peric-Hupkes, Stacey Joosten, Hans Teunissen, Anoek Friskes, Mila Ilic, Dorine Hintzen, Vinicius H. Franceschini-Santos, Wilbert Zwart, Elzo de Wit, Bas van Steensel, Rene H. Medema
Summary: Acquired drug resistance is a major problem in cancer treatment. The study reveals that dissociation of the nuclear lamina can lead to derepression of the ABCB1 gene, resulting in drug resistance. This finding suggests that disruption of 3D genome topology plays an important role in tumor evolution and the acquisition of drug resistance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Esther Strating, Anne van de Loo, Sjoerd Elias, Marnix Lam, Onno Kranenburg
Article
Oncology
Janneke W. de Boer, Kylie Keijzer, Elise R. A. Pennings, Jaap A. van Doesum, Anne M. Spanjaart, Margot Jak, Pim G. N. J. Mutsaers, Suzanne van Dorp, Joost S. P. Vermaat, Marjolein W. M. van der Poel, Lisanne V. van Dijk, Marie Jose Kersten, Anne G. H. Niezink, Tom van Meerten, Dutch CAR-T Tumorboard Consortium
Summary: CAR-T cell therapy has become the standard treatment for patients with relapsed or refractory large B-cell lymphoma. However, it can be accompanied by toxicities. It is important to identify patients at risk for these toxicities in order to start early intervention. Existing risk scores for predicting these toxicities have limitations and require further validation and optimization.