期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 60, 期 -, 页码 133-143出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2021.05.003
关键词
svVEGF; VEGF; Angiogenesis; Vascular endothelial growth factors; Snake
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) [001]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo Research Foundation) [2017/03580-9]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, The National Council for Scientific and Technological Development) [307184/2020-0, 303689/2013-7]
- Hamish Ogston Foundation -Global Snakebite Initiative
VEGF is a crucial regulator of angiogenesis in both physiological and pathological conditions. It is categorized into seven families, with different types found in mammals, viruses, and snake venoms. This review focuses on the svVEGF family, exploring its distribution, molecular structure, functions, and potential applications within snake venoms.
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis, a physiological process characterized by the formation of new vessels from a preexisting endothelium. VEGF has also been implicated in pathologic states, such as neoplasias, intraocular neovascular disorders, among other conditions. VEGFs are distributed in seven different families: VEGF-A, B, C, D, and PIGF (placental growth factor), which are identified in mammals; VEGF-E, which are encountered in viruses; and VEGF-F or svVEGF (snake venom VEGF) described in snake venoms. This is the pioneer review of svVEGF family, exploring its distribution among the snake venoms, molecular structure, main functions, and potential applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据