标题
Emerging roles of regulatory T cells in tumour progression and metastasis
作者
关键词
Regulatory T cells, Patient prognosis, Metastasis, Metastatic foci development, Therapeutics
出版物
CANCER AND METASTASIS REVIEWS
Volume 33, Issue 4, Pages 1025-1041
出版商
Springer Nature
发表日期
2014-10-30
DOI
10.1007/s10555-014-9529-x
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Tumors That Acquire Resistance to Low-Dose Metronomic Cyclophosphamide Retain Sensitivity to Maximum Tolerated Dose Cyclophosphamide
- (2015) Urban Emmenegger et al. NEOPLASIA
- Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients
- (2014) H. R. Ali et al. ANNALS OF ONCOLOGY
- A novel oxygen carrier “YQ23” suppresses the liver tumor metastasis by decreasing circulating endothelial progenitor cells and regulatory T cells
- (2014) Chang Xian Li et al. BMC CANCER
- Complement C5a Receptor Facilitates Cancer Metastasis by Altering T-Cell Responses in the Metastatic Niche
- (2014) S. K. Vadrevu et al. CANCER RESEARCH
- Regulatory T cells in cancer immunotherapy
- (2014) Hiroyoshi Nishikawa et al. CURRENT OPINION IN IMMUNOLOGY
- Phenotypic alterations, clinical impact and therapeutic potential of regulatory T cells in cancer
- (2014) Belal Chaudhary et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Pan-Bcl-2 Inhibitor, GX15-070 (Obatoclax), Decreases Human T Regulatory Lymphocytes while Preserving Effector T Lymphocytes: A Rationale for Its Use in Combination Immunotherapy
- (2014) P. S. Kim et al. JOURNAL OF IMMUNOLOGY
- Regulatory T Cells and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment Undergo Fas-Dependent Cell Death during IL-2/ CD40 Therapy
- (2014) J. M. Weiss et al. JOURNAL OF IMMUNOLOGY
- Breast cancer metastasis: demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12
- (2014) Stephen Douglass et al. JOURNAL OF PATHOLOGY
- Adenosine A2B receptor antagonist PSB603 suppresses tumor growth and metastasis by inhibiting induction of regulatory T cells
- (2014) Wakako Kaji et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- Tumor-infiltrating PD1-Positive Lymphocytes and FoxP3-Positive Regulatory T Cells Predict Distant Metastatic Relapse and Survival of Clear Cell Renal Cell Carcinoma
- (2014) Myoung Jae Kang et al. Translational Oncology
- Organ-Specific and Memory Treg Cells: Specificity, Development, Function, and Maintenance
- (2014) Iris K. Gratz et al. Frontiers in Immunology
- Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment
- (2014) Stefani Spranger et al. Journal for ImmunoTherapy of Cancer
- FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast
- (2013) Aseem Lal et al. BREAST CANCER RESEARCH AND TREATMENT
- Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis
- (2013) Martin Chopra et al. CARCINOGENESIS
- Primary 4T1 tumor resection provides critical “window of opportunity” for immunotherapy
- (2013) Anahit Ghochikyan et al. CLINICAL & EXPERIMENTAL METASTASIS
- Predictive and prognostic factors in locally advanced breast cancer: effect of intratumoral FOXP3+ Tregs
- (2013) Lutfiye Demir et al. CLINICAL & EXPERIMENTAL METASTASIS
- Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
- (2013) B. Allard et al. CLINICAL CANCER RESEARCH
- Humanized mice: novel model for studying mechanisms of human immune-based therapies
- (2013) Louis Gonzalez et al. IMMUNOLOGIC RESEARCH
- Immune profiles of CD4+ lymphocyte subsets in breast cancer tumor draining lymph nodes
- (2013) Zahra Faghih et al. IMMUNOLOGY LETTERS
- Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer
- (2013) Ngar-Yee Huen et al. INTERNATIONAL JOURNAL OF CANCER
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
- (2013) Tyler R. Simpson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
- (2013) Paula D. Bos et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Inhibition of Breast Cancer Metastasis by Resveratrol-Mediated Inactivation of Tumor-Evoked Regulatory B Cells
- (2013) C. Lee-Chang et al. JOURNAL OF IMMUNOLOGY
- Host B7x Promotes Pulmonary Metastasis of Breast Cancer
- (2013) Y. M. Abadi et al. JOURNAL OF IMMUNOLOGY
- Active Demethylation of the Foxp3 Locus Leads to the Generation of Stable Regulatory T Cells within the Thymus
- (2013) A. Toker et al. JOURNAL OF IMMUNOLOGY
- Listeria monocytogenes (Lm)-LLO Immunotherapies Reduce the Immunosuppressive Activity of Myeloid-derived Suppressor Cells and Regulatory T Cells in the Tumor Microenvironment
- (2013) Anu Wallecha et al. JOURNAL OF IMMUNOTHERAPY
- Inhibition of Lung Metastasis by Chemokine CCL17-mediated In Vivo Silencing of Genes in CCR4+ Tregs
- (2013) Arya Biragyn et al. JOURNAL OF IMMUNOTHERAPY
- Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
- (2013) Jérôme Galon et al. JOURNAL OF PATHOLOGY
- Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC
- (2013) Chandan Verma et al. Journal of Translational Medicine
- Unknown
- (2013) Heike Pohla et al. MOLECULAR MEDICINE
- Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
- (2013) Greg M. Delgoffe et al. NATURE
- CCR7 Expression and Intratumoral FOXP3+ Regulatory T Cells are Correlated with Overall Survival and Lymph Node Metastasis in Gastric Cancer
- (2013) Shuang Zhou et al. PLoS One
- Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans
- (2013) D. Sugiyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells
- (2013) S. Spranger et al. Science Translational Medicine
- FOXP3 and TLR4 protein expression are correlated in non-small cell lung cancer: Implications for tumor progression and escape
- (2012) Hai-ying Fu et al. ACTA HISTOCHEMICA
- Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance
- (2012) Angelina M. Bilate et al. Annual Review of Immunology
- Tumour-infiltrating FOXP3+ lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer
- (2012) N R West et al. BRITISH JOURNAL OF CANCER
- Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease
- (2012) T. Dalotto-Moreno et al. CANCER RESEARCH
- T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis
- (2012) A. Facciabene et al. CANCER RESEARCH
- CCL2 is critical for immunosuppression to promote cancer metastasis
- (2012) Chie Kudo-Saito et al. CLINICAL & EXPERIMENTAL METASTASIS
- Phenotypic and functional characteristics of CD4+CD39+ FOXP3+ and CD4+CD39+FOXP3neg T-cell subsets in cancer patients
- (2012) Patrick J. Schuler et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma
- (2012) Luc Bron et al. INTERNATIONAL JOURNAL OF CANCER
- Increased number of regulatory T cells (T-regs) in the peripheral blood of patients with Her-2/neu-positive early breast cancer
- (2012) Thomas Decker et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- FOXP3 expression in tumor cells and implications for cancer progression
- (2012) Tiziana Triulzi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Programmed Death-1+T Cells and Regulatory T Cells Are Enriched in Tumor-Involved Lymph Nodes and Associated with Aggressive Features in Papillary Thyroid Cancer
- (2012) Jena D. French et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Definition and Impact of Pathologic Complete Response on Prognosis After Neoadjuvant Chemotherapy in Various Intrinsic Breast Cancer Subtypes
- (2012) Gunter von Minckwitz et al. JOURNAL OF CLINICAL ONCOLOGY
- Neuropilin 1 deficiency on CD4+Foxp3+regulatory T cells impairs mouse melanoma growth
- (2012) Wiebke Hansen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cancer classification using the Immunoscore: a worldwide task force
- (2012) Jérôme Galon et al. Journal of Translational Medicine
- Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
- (2012) Harald von Boehmer et al. NATURE REVIEWS DRUG DISCOVERY
- Immunobiology of human mucin 1 in a preclinical ovarian tumor model
- (2012) R A Budiu et al. ONCOGENE
- Regulation of COX2 Expression in Mouse Mammary Tumor Cells Controls Bone Metastasis and PGE2-Induction of Regulatory T Cell Migration
- (2012) John Karavitis et al. PLoS One
- Know thy enemy
- (2012) Andrea Facciabene et al. OncoImmunology
- FOXP3 and survival in urinary bladder cancer
- (2011) Malin E. Winerdal et al. BJU INTERNATIONAL
- CD8+ cytotoxic T cell and FOXP3+ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes
- (2011) Fangfang Liu et al. BREAST CANCER RESEARCH AND TREATMENT
- Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer
- (2011) Kristoffer Watten Brudvik et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Immunotherapy with MVA-BN®-HER2 induces HER-2-specific Th1 immunity and alters the intratumoral balance of effector and regulatory T cells
- (2011) Stefanie J. Mandl et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer
- (2011) Sylvain Ladoire et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome
- (2011) Yingzi Ge et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Targeting Regulatory T Cells in Cancer
- (2011) W. L. Byrne et al. CANCER RESEARCH
- Identification of a Tumor Suppressor Relay between the FOXP3 and the Hippo Pathways in Breast and Prostate Cancers
- (2011) W. Li et al. CANCER RESEARCH
- Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells
- (2011) P. B. Olkhanud et al. CANCER RESEARCH
- Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis
- (2011) T. Tanikawa et al. CANCER RESEARCH
- Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs
- (2011) Eyad Elkord et al. CLINICAL IMMUNOLOGY
- CD83+ dendritic cells and Foxp3+ regulatory T cells in primary lesions and regional lymph nodes are inversely correlated with prognosis of gastric cancer
- (2011) Seigo Kashimura et al. Gastric Cancer
- Regulatory T Cells Target Chemokine Secretion by Dendritic Cells Independently of Their Capacity To Regulate T Cell Proliferation
- (2011) S. Morlacchi et al. JOURNAL OF IMMUNOLOGY
- IL-17 + Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer
- (2011) Ilona Kryczek et al. JOURNAL OF IMMUNOLOGY
- Foxp3+ Regulatory T Cells and Natural Killer Cells Distinctly Infiltrate Primary Tumors and Draining Lymph Nodes in Pulmonary Adenocarcinoma
- (2011) Thomas Schneider et al. Journal of Thoracic Oncology
- Intratumoral regulatory T cells alone or in combination with cytotoxic T cells predict prognosis of hepatocellular carcinoma after resection
- (2011) Kang-jie Chen et al. MEDICAL ONCOLOGY
- Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling
- (2011) Wei Tan et al. NATURE
- Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
- (2011) Andrea Facciabene et al. NATURE
- Immune parameters affecting the efficacy of chemotherapeutic regimens
- (2011) Laurence Zitvogel et al. Nature Reviews Clinical Oncology
- FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells
- (2011) N McInnes et al. ONCOGENE
- Making sense of regulatory T cell suppressive function
- (2011) Itay Shalev et al. SEMINARS IN IMMUNOLOGY
- Moving to tolerance: Clinical application of T regulatory cells
- (2011) Alicia N. McMurchy et al. SEMINARS IN IMMUNOLOGY
- Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions
- (2011) Tomoyuki Yamaguchi et al. SEMINARS IN IMMUNOLOGY
- Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy
- (2010) Sylvain Ladoire et al. BREAST CANCER RESEARCH AND TREATMENT
- An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer
- (2010) Sahar M. A. Mahmoud et al. BREAST CANCER RESEARCH AND TREATMENT
- Development of a live and highly attenuated Listeria monocytogenes-based vaccine for the treatment of Her2/neu-overexpressing cancers in human
- (2010) V Shahabi et al. CANCER GENE THERAPY
- Foxp3+ cell infiltration and granzyme B+/Foxp3+ cell ratio are associated with outcome in neoadjuvant chemotherapy-treated ovarian carcinoma
- (2010) Martin Pölcher et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- The Predictive Value of HLA Class I Tumor Cell Expression and Presence of Intratumoral Tregs for Chemotherapy in Patients with Early Breast Cancer
- (2010) E. M. de Kruijf et al. CLINICAL CANCER RESEARCH
- Enrichment of CCR6+Foxp3+ regulatory T cells in the tumor mass correlates with impaired CD8+ T cell function and poor prognosis of breast cancer
- (2010) Lin Xu et al. CLINICAL IMMUNOLOGY
- Study of T Lymphocytes Infiltrating Peritoneal Metastases in Advanced Ovarian Cancer
- (2010) Marinos L. Tsiatas et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Inflammatory Effects of Ex Vivo Human Th17 Cells Are Suppressed by Regulatory T Cells
- (2010) S. Q. Crome et al. JOURNAL OF IMMUNOLOGY
- LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites
- (2010) C. Camisaschi et al. JOURNAL OF IMMUNOLOGY
- Regulatory (FoxP3+) T-cell Tumor Infiltration Is a Favorable Prognostic Factor in Advanced Colon Cancer Patients Undergoing Chemo or Chemoimmunotherapy
- (2010) Pierpaolo Correale et al. JOURNAL OF IMMUNOTHERAPY
- Tumor-Infiltrating Foxp3+ Regulatory T Cells are Correlated with Cyclooxygenase-2 Expression and are Associated with Recurrence in Resected Non-small Cell Lung Cancer
- (2010) Katsuhiko Shimizu et al. Journal of Thoracic Oncology
- Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer
- (2009) Aaron S Mansfield et al. BMC CANCER
- Stromal regulatory T-cells are associated with a favourable prognosis in gastric cancer of the cardia
- (2009) Matthias Haas et al. BMC GASTROENTEROLOGY
- Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway
- (2009) Olga V Efimova et al. BMC IMMUNOLOGY
- Homeostasis of peripheral FoxP3+ CD4+ regulatory T cells in patients with early and late stage breast cancer
- (2009) Andrew J. Rech et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- FOXP3 Defines Regulatory T Cells in Human Tumor and Autoimmune Disease
- (2009) I. Kryczek et al. CANCER RESEARCH
- Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells
- (2009) P. B. Olkhanud et al. CANCER RESEARCH
- Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome
- (2009) M. Gobert et al. CANCER RESEARCH
- Expression of FOXP3 in esophageal squamous cell carcinoma relating to the clinical data
- (2009) L. Xue et al. DISEASES OF THE ESOPHAGUS
- Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
- (2009) Makoto Miyara et al. IMMUNITY
- Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells
- (2009) Magis Mandapathil et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FOXP3 Expression and Overall Survival in Breast Cancer
- (2009) Andrea Merlo et al. JOURNAL OF CLINICAL ONCOLOGY
- Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
- (2009) Graham P. Wright et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- How do Regulatory T Cells Work?
- (2009) A. Corthay SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix
- (2009) Paulo Cesar Maciag et al. VACCINE
- The prognostic value of peritumoral regulatory T cells and its correlation with intratumoral cyclooxygenase-2 expression in clear cell renal cell carcinoma
- (2008) Jin F. Li et al. BJU INTERNATIONAL
- Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death
- (2008) D. Mougiakakos et al. BLOOD
- Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T Cells
- (2008) S. Ladoire et al. CLINICAL CANCER RESEARCH
- Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3
- (2008) Sarah E. Allan et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma
- (2008) A. Tzankov et al. HAEMATOLOGICA
- The T-cell receptor repertoire of regulatory T cells
- (2008) Rafal Pacholczyk et al. IMMUNOLOGY
- Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer
- (2008) Paul Salama et al. JOURNAL OF CLINICAL ONCOLOGY
- The tumor microenvironment and its role in promoting tumor growth
- (2008) T L Whiteside ONCOGENE
- CTLA-4 Control over Foxp3+ Regulatory T Cell Function
- (2008) K. Wing et al. SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started