Article
Oncology
Xiang Xu, Na Li, Yugang Wang, Jinming Yu, Jun Mi
Summary: The upregulation of calcium channel TRPV6 is associated with poor prognosis in breast cancer by promoting invasion and metastasis, making it a potential target for therapy. TRPV6 expression is increased in metastatic breast cancers, accelerating primary breast cancer cell migration. Mechanistically, TRPV6 activates NFATC2 through NFATC2IP phosphorylation, leading to increased breast cancer metastasis via upregulation of ADAMTS6 expression.
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Pathology
Rui Zhang, Ziqi Meng, Xuwei Wu, Meihua Zhang, Songnan Zhang, Tiefeng Jin
Summary: The research demonstrated that Mortalin promotes proliferation, metastasis, and malignant progression of breast cancer, potentially through the Wnt/beta-Catenin signaling pathway. This suggests that Mortalin could serve as a biomarker and prognostic factor in breast cancer.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Qian Li, Xuejiao Lv, Chunyong Han, Yu Kong, Zhongye Dai, Dawei Huo, Ting Li, Dapeng Li, Wei Li, Xing Wang, Qian Zhao, Jie Ming, Wen Yang, Yang Chen, Xudong Wu
Summary: This study investigates the transcriptomic and epigenomic features of NFs and CAFs associated with breast cancer metastasis, and identifies signature genes and enhancers specific to CAFs. The study demonstrates the importance of activated JUN in remodeling enhancers and maintaining the activation of CAF-specific enhancers, leading to breast cancer invasiveness. These findings provide insights into stroma cell transformation and support the potential of stroma-targeting strategy in cancer treatment.
Article
Biochemistry & Molecular Biology
Dandan Duan, Mengjie Shang, Yanxu Han, Jiayuan Liu, Jiwei Liu, Sun Hyok Kong, Jingyao Hou, Baiqu Huang, Jun Lu, Yu Zhang
Summary: This study reveals that EZH2 promotes the formation of CCF and activates the cGAS-STING pathway to enhance breast cancer metastasis. The EZH2-HMGA1-USP7 complex is involved in the regulation of CCF formation. EZH2 can activate cGAS through CCF, requiring the deubiquitination activity of USP7. Targeting the EZH2-CCF-cGAS axis may be a potential therapeutic strategy for inhibiting breast cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anupama Vadhan, Ming-Feng Hou, Priya Vijayaraghavan, Yi-Chia Wu, Stephen Chu-Sung Hu, Yun-Ming Wang, Tian-Lu Cheng, Yen-Yun Wang, Shyng-Shiou F. Yuan
Summary: CD44 plays a key role in breast cancer metastasis by downregulating nuclear FOXA2.
Article
Multidisciplinary Sciences
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson
Summary: Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. The characterization of a human IBC cell line in this study suggests that the high level of CCL2 is implicated in macrophage infiltration and tumor progression.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Qin Huo, Siqi Chen, Jialang Zhuang, Chuntao Quan, Yue Wang, Ni Xie
Summary: This study demonstrates that the interaction between SIRT7 and LAP2 alpha plays a critical role in regulating chromosomal instability (CIN) and metastasis in breast cancer. The loss of SIRT7 leads to CIN in breast cancer cells, while degradation of LAP2 alpha also increases CIN in breast cancer cells. Furthermore, in vitro and in vivo experiments confirmed that SIRT7 promotes breast cancer metastasis through the SIRT7/LAP2 alpha axis. Inhibition of the SIRT7/LAP2 alpha axis may represent a potential therapeutic strategy for preventing breast cancer metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Zeyu Xing, Ruojiao Wang, Xin Wang, Jiaqi Liu, Menglu Zhang, Kexin Feng, Xiang Wang
Summary: The study demonstrated that circPDCD11 functions as an oncogene in triple-negative breast cancer (TNBC), promoting metabolic activity and tumor growth. This circRNA serves as a miRNA sponge to upregulate LDHA expression, providing a potential prognostic biomarker for TNBC.
CELL DEATH DISCOVERY
(2021)
Article
Medicine, Research & Experimental
Federica Zilli, Pedro Marques Ramos, Priska Auf Der Maur, Charly Jehanno, Atul Sethi, Marie-May Coissieux, Tobias Eichlisberger, Loic Sauteur, Adelin Rouchon, Laura Bonapace, Joana Pinto Couto, Roland Rad, Michael Rugaard Jensen, Andrea Banfi, Michael B. Stadler, Mohamed Bentires-Alj
Summary: NFIB is a transcription factor that plays a crucial role in promoting primary mammary tumor growth and lung metastatic colonization by increasing the expression of ERO1A. Its high expression is associated with poor prognosis in basal-like breast cancer patients.
EMBO MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Shuya Luo, Hui Wang, Lichuan Bai, Yiwen Chen, Si Chen, Kuan Gao, Huijie Wang, Shuwei Wu, Hanbin Song, Ke Ma, Mei Liu, Fan Yao, Yue Fang, Qinghuan Xiao
Summary: Activation of TMEM16A promoted breast cancer cell migration and invasion in vitro as well as breast cancer metastasis in mice. Patients with higher TMEM16A levels showed greater lymph node metastasis and shorter survival.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lili Gao, Junzhe Zhang, Qianqian Long, Yang Yang, Yiming Li, Guoqiang Li, Peng Pu, Shanshi Tong, Yamin He, Qing Li, Yang Chen, Yingbin Liu, Xianming Kong
Summary: This study reveals a novel pathway, the SETD7/YY1 axis, which regulates epithelial-mesenchymal transition and tumor cell migration via the ERK/MAPK pathway in triple-negative breast cancer (TNBC). These findings suggest a potential therapeutic target for advanced TNBC treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Lingxia Liu, Xiliu Zhang, Huayi Ding, Xin Liu, Donghui Cao, Yingqi Liu, Jiwei Liu, Cong Lin, Na Zhang, Guannan Wang, Jingyao Hou, Baiqu Huang, Yu Zhang, Jun Lu
Summary: This study uncovered a unique mechanism of controlling OXPHOS through arginine and lysine methylation, and highlighted the impact of the PRMT7-SETD6-MRPS23 axis during breast cancer metastasis.
Article
Biochemistry & Molecular Biology
Yan Luo, Qingyun Zhu, Shasha Xiang, Qi Wang, Jun Li, Xiguang Chen, Wen Yan, Jianbo Feng, Xuyu Zu
Summary: A novel metastasis suppressive circular RNA, circPOKE, has been identified in breast cancer. circPOKE binds to USP10 and reduces its binding to Snail, thereby affecting Snail stability and inhibiting the metastatic potential of breast cancer cells through the protein-ubiquitination degradation pathway. Additionally, circPOKE can be secreted into the extracellular space via exosomes and significantly inhibits the invasive capabilities of breast cancer cells. These findings suggest that circPOKE may serve as a potential therapeutic target for breast cancer metastasis.
Article
Oncology
Emilly S. Villodre, Xiaoding Hu, Richard Larson, Pascal Finetti, Kristen Gomez, Wintana Balema, Shane R. Stecklein, Ginette Santiago-Sanchez, Savitri Krishnamurthy, Juhee Song, Xiaoping Su, Naoto T. Ueno, Debu Tripathy, Steven Van Laere, Francois Bertucci, Pablo Vivas-Mejia, Wendy A. Woodward, Bisrat G. Debeb
Summary: The study found that lipocalin 2 (LCN2) is expressed at significantly higher levels in inflammatory breast cancer (IBC) and is associated with poor prognosis features and shorter overall survival in IBC patients. Depletion of LCN2 can inhibit aggressive behavior of IBC cells in vivo and suppress tumor growth and invasion in mouse models of IBC. Analysis of proteomics data showed reduced expression of proteins involved in cell cycle and DNA repair in LCN2-silenced IBC cells, indicating LCN2 promotes IBC tumor aggressiveness and could be a potential therapeutic target for IBC.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Patrick P. C. Boor, Kostandinos Sideras, Katharina Biermann, M. Hosein Aziz, Iris J. M. Levink, Shanta Mancham, Nicole S. Erler, Xudong Tang, Casper H. van Eijck, Marco J. Bruno, Dave Sprengers, Xingxing Zang, Jaap Kwekkeboom
BRITISH JOURNAL OF CANCER
(2020)
Article
Cell Biology
Zhen Zhang, Jinyan Liu, Chaoqi Zhang, Feng Li, Lifeng Li, Dan Wang, Damini Chand, Fangxia Guan, Xingxing Zang, Yi Zhang
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Yuxin Li, Yao Liu, Na Zhao, Xiaojun Yang, Yaqing Li, Fangzheng Zhai, Xingxing Zang, Wei Cui
CELL DEATH & DISEASE
(2020)
Article
Oncology
Ziqiang Yuan, Juliet C. Gardiner, Elaine C. Maggi, Shuyu Huang, Asha Adem, Svetlana Bagdasarov, Guiying Li, Sylvia Lee, Daniel Slegowski, Alyssa Exarchakis, James R. Howe, Edmund C. Lattime, Xingxing Zang, Steven K. Libutti
Summary: The study found that HHLA2 and B7x are highly expressed in GINETs and PNETs, and correlate with malignancy and spread. The overexpression of HIF-1 alpha is associated with the upregulation of B7x, and Men1/B7x double knockout mice show increased T-cell infiltration. Targeting B7x may offer a promising strategy for immunotherapy in patients with NETs.
ENDOCRINE-RELATED CANCER
(2021)
Article
Oncology
Phillip M. Galbo, Xingxing Zang, Deyou Zheng
Summary: This study conducted a comprehensive analysis of CAFs from multiple cancer types, identified shared molecular characteristics in CAF subtypes, and revealed the association of different CAF subtypes with clinical outcomes and immunotherapy resistance.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Wei Zhang, Ana Acuna-Villaorduna, Kevin Kuan, Sorab Gupta, Shaomin Hu, Kim Ohaegbulam, Joseph Albanese, Meghan Kaumaya, Rachel Levy, Richard R. Hwang, Xingxing Zang, Juan Lin, Qiang Liu, Radhashree Maitra, Sanjay Goel
Summary: Low expression of both PD-L1 and B7-H3 in colorectal cancer is associated with better survival outcomes, without significant variation among different racial groups in terms of relevant protein markers for CRC.
CLINICAL COLORECTAL CANCER
(2021)
Review
Biochemistry & Molecular Biology
Christopher D. Nishimura, Marc C. Pulanco, Wei Cui, Liming Lu, Xingxing Zang
Summary: This article discusses the ligand-ligand cis-interaction between PD-L1 and B7-1 and its impact on immune checkpoint pathways, suggesting significant crosstalk between these pathways and providing new insights for immunotherapies and treatments.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Oncology
Qianghua Zhou, Kaiwen Li, Yiming Lai, Kai Yao, Qiong Wang, Xiangyu Zhan, Shirong Peng, Wenli Cai, Wei Yao, Xingxing Zang, Kewei Xu, Jian Huang, Hai Huang
Summary: Both B7-H3 and HHLA2 have a critical impact on the immunosuppressive microenvironment in PCa. The B7 score, combined with CD8(+) TILs, can be used as a new immune classification to stratify the risk of death, especially cancer-related death, for patients with PCa.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Yao Wei, Xiaoxin Ren, Phillip M. Galbo, Scott Moerdler, Hao Wang, R. Alejandro Sica, Bijan Etemad-Gilbertson, Lei Shi, Liqiang Zhu, Xudong Tang, Qi Lin, Mou Peng, Fangxia Guan, Deyou Zheng, Jordan M. Chinai, Xingxing Zang
Summary: HHLA2 is a promising target for cancer immunotherapy due to its coinhibitory function and overexpression in human cancers. The KIR3DL3-HHLA2 pathway may be a potential immunotherapeutic target for cancer.
SCIENCE IMMUNOLOGY
(2021)
Article
Hematology
Ilseyar Akhmetzyanova, Tonya Aaron, Phillip Galbo, Anastasia Tikhonova, Igor Dolgalev, Masato Tanaka, Iannis Aifantis, Deyou Zheng, Xingxing Zang, David Fooksman
Summary: The dissemination and progression of multiple myeloma is associated with an increased inflammatory signature in bone marrow MPs, with CD169(+) MPs playing a critical role in the early spread of myeloma.
Article
Multidisciplinary Sciences
Peter John, Marc C. Pulanco, Phillip M. Galbo, Yao Wei, Kim C. Ohaegbulam, Deyou Zheng, Xingxing Zang
Summary: B7x, an immune checkpoint molecule, promotes the conversion of CD4+ T cells into regulatory T cells within the tumor microenvironment. It induces transcriptomic changes in regulatory T cells, altering their phenotype to an activated and suppressive state. B7x-mediated regulation reduces the efficacy of anti-CTLA-4 treatment, but combination therapy with anti-B7x and anti-CTLA-4 overcomes this resistance and shows synergistic therapeutic efficacy.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Elodie Picarda, Phillip M. Galbo, Haihong Zong, Meenu Rohini Rajan, Ville Wallenius, Deyou Zheng, Emma Borgeson, Rajat Singh, Jeffrey Pessin, Xingxing Zang
Summary: The immune checkpoint B7-H3 has been studied in the tumor microenvironment and immunotherapy, but its potential role in metabolism remains largely unknown. This study reveals that B7-H3 is highly expressed in adipose tissue, particularly in adipocyte progenitor cells, and it regulates the glycolytic and mitochondrial activity of these cells. Loss of B7-H3 leads to impaired oxidative metabolism and increased lipid accumulation in derived adipocytes. Knockout of B7-H3 in mice results in spontaneous obesity, metabolic dysfunction, and adipose tissue inflammation.
Review
Immunology
Marc C. Pulanco, Anne T. Madsen, Ankit Tanwar, Devin T. Corrigan, Xingxing Zang
Summary: The B7/CD28 families of immune checkpoints play important roles in regulating immune cells and are closely related to various diseases. Recent studies have discovered new pathways and therapeutics for cancer therapy in this field. This review covers the newly discovered KIR3DL3/TMIGD2/HHLA2 pathways, metabolic regulation by PD-1/PD-L1 and B7-H3, the glycobiology of PD-1/PD-L1, B7x, and B7-H3, as well as the interaction between PD-L1 and B7-1. The article also discusses the resistance mechanisms to current immunotherapies targeting PD-1/PD-L1 and CTLA-4 in clinical settings, and reviews new immunotherapies targeting B7-H3, B7x, PD-1/PD-L1, and CTLA-4 in ongoing clinical trials.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xiaoxin Ren, Yixian Li, Christopher Nishimura, Xingxing Zang
Summary: Somatic activating mutations in EGFR are common in various cancers. Targeted therapies against EGFR have shown clinical efficacy, but acquired resistance is a challenge. PD-1/PD-L1 immune checkpoint inhibitors are effective in some cancers, but limited in EGFR mutated cancers. Up-regulation of new B7/CD28 family members related to EGFR signaling may contribute to immunosuppressive tumor microenvironment and resistance to EGFR-targeted therapies. Understanding these interactions could inform combination therapeutic strategies.
Article
Oncology
Scott Moerdler, Michelle Ewart, Debra L. Friedman, Kara Kelly, Qinglin Pei, Mou Peng, XingXing Zang, Peter D. Cole
Summary: In pediatric Hodgkin lymphoma, LAG-3 expression is found to be positively correlated with PD-L1 expression, serving as an innovative immune checkpoint target with unclear association to patient outcomes.
LEUKEMIA & LYMPHOMA
(2021)