Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10

An Immunocytochemical-Derived Correlate for Evaluating the Bridging of Heteromeric Mu-Delta Opioid Protomers by Bivalent Ligands

(2013) Ajay S. Yekkirala et al.   ACS Chemical Biology

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB1) Receptors Are Potent Analgesics Devoid of Tolerance

(2013) Morgan Le Naour et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Kinase C  Is Required for Spinal Analgesic Synergy between Delta Opioid and Alpha-2A Adrenergic Receptor Agonist Pairs

(2013) D. J. Schuster et al.   JOURNAL OF NEUROSCIENCE

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Identification of a  -  opioid receptor heteromer-biased agonist with antinociceptive activity

(2013) I. Gomes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception

(2013) E. Akgun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A bivalent ligand targeting the putative mu opioid receptor and chemokine receptor CCR5 heterodimer: binding affinity versus functional activities

(2013) Yunyun Yuan et al.   MedChemComm

The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ–δ Opioid Receptors

(2012) Matthew D. Metcalf et al.   ACS Chemical Neuroscience

μ-opioid and 5-HT1A receptors heterodimerize and show signalling crosstalk via G protein and MAP-kinase pathways

(2012) Didier Cussac et al.   CELLULAR SIGNALLING

6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment

(2012) Marie-Laure Rives et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5

(2012) Yunyun Yuan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Receptor Heteromerization Expands the Repertoire of Cannabinoid Signaling in Rodent Neurons

(2012) Raphael Rozenfeld et al.   PLoS One

Dimerization with Cannabinoid Receptors Allosterically Modulates Delta Opioid Receptor Activity during Neuropathic Pain

(2012) Ittai Bushlin et al.   PLoS One

Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers

(2012) Jessica H. Harvey et al.   ACS Medicinal Chemistry Letters

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

(2011) Ruben Vardanyan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids

(2011) Xian-Yu Liu et al.   CELL

Heterodimerization of human apelin and kappa opioid receptors: Roles in signal transduction

(2011) Yalin Li et al.   CELLULAR SIGNALLING

Sequential and opposing alterations of 5-HT1A receptor function during withdrawal from chronic morphine

(2011) Pierre-Eric Lutz et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Protein Kinase Cζ Mediates μ-Opioid Receptor-induced Cross-desensitization of Chemokine Receptor CCR5

(2011) Changcheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heteromerization of the  - and  -Opioid Receptors Produces Ligand-Biased Antagonism and Alters  -Receptor Trafficking

(2011) L. Milan-Lobo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

G Protein-Coupled Receptor Heteromerization: A Role in Allosteric Modulation of Ligand Binding

(2011) I. Gomes et al.   MOLECULAR PHARMACOLOGY

Facilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Codegradation

(2011) Shao-Qiu He et al.   NEURON

N-naphthoyl- -naltrexamine (NNTA), a highly selective and potent activator of  / -opioid heteromers

(2011) A. S. Yekkirala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

(2011) S. Majumdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of  -/ -opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia

(2010) S. Chakrabarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Abundance of Opioid Receptor Heteromers After Chronic Morphine Administration

(2010) A. Gupta et al.   Science Signaling

Heterodimerization of ORL1 and Opioid Receptors and Its Consequences for N-type Calcium Channel Regulation

(2009) Rhian M. Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 MAPK and β-Arrestin 2 Mediate Functional Interactions between Endogenous μ-Opioid and α2A-Adrenergic Receptors in Neurons

(2009) Miao Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C Mediates the Synergistic Interaction Between Agonists Acting at  2-Adrenergic and Delta-Opioid Receptors in Spinal Cord

(2009) A. C. Overland et al.   JOURNAL OF NEUROSCIENCE

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the μ-opioid receptor

(2009) H. Schröder et al.   NEUROPHARMACOLOGY

Ligand stabilization of CXCR4/δ-opioid receptor heterodimers reveals a mechanism for immune response regulation

(2008) Oscar M. Pello et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

μ-Opioid Receptor Forms a Functional Heterodimer With Cannabinoid CB1 Receptor: Electrophysiological and FRET Assay Analysis

(2008) Minoru Hojo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Cell surface targeting of  -  opioid receptor heterodimers by RTP4

(2008) F. M. Decaillot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

μ opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis

(2006) Carl Rios et al.   BRITISH JOURNAL OF PHARMACOLOGY