期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 16, 页码 4741-4744出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.06.140
关键词
Neuropeptide Y; NPY Y5; Antagonists
A novel class of small molecule NPY Y5 antagonists based around an azabicyclo[3.1.0]hexane scaffold was identified through modi. cation of a screening hit. Structure-activity relationships and efforts undertaken to achieve a favourable pharmacokinetic pro. le in rat are described. (C) 2010 Elsevier Ltd. All rights reserved.
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