hERG subunit composition determines differential drug sensitivity

Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels

(2010) AP Larsen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines

(2010) Jean-Pierre Valentin et al.   BRITISH JOURNAL OF PHARMACOLOGY

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk

(2010) CE Pollard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel

(2009) R Männikkö et al.   BRITISH JOURNAL OF PHARMACOLOGY

Physiological Properties of hERG 1a/1b Heteromeric Currents and a hERG 1b-Specific Mutation Associated With Long-QT Syndrome

(2008) Harinath Sale et al.   CIRCULATION RESEARCH

Kv11.1 channel subunit composition includes minK and varies developmentally in mouse cardiac muscle

(2008) Xun Wang et al.   DEVELOPMENTAL DYNAMICS

Characterization of hERG1a and hERG1b potassium channels—a possible role for hERG1b in the I Kr current

(2008) Anders Peter Larsen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Safety and secondary pharmacology: Successes, threats, challenges and opportunities

(2008) Jean-Pierre Valentin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks™

(2007) A.R. Harmer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS