Review
Pharmacology & Pharmacy
Laura Chaffey, Annabell Roberti, David R. Greaves
Summary: Drug repurposing is a promising approach in drug discovery for cardiovascular disease. Chronic inflammation plays a significant role in cardiovascular pathology, and targeting inflammation is a potential therapeutic strategy. However, challenges remain due to off-target effects and long-term conditions. Assessing repurposed anti-inflammatory drugs in cardiovascular clinical trials has shown mixed successes.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Geriatrics & Gerontology
Milta O. Little, John E. Morley
Summary: Older adults in North America face similar challenges to successful ageing as other adults around the world, including an increased risk of geriatric syndromes and functional decline. Despite the establishment of geriatrics as a specialty and the creation of screening tools for early identification of geriatric syndromes, there are significant gaps in care due to workforce shortages in all older adult care service areas.
Article
Computer Science, Artificial Intelligence
Adrien Becue, Isabel Praca, Joao Gama
Summary: This survey paper explores the opportunities and threats of using artificial intelligence (AI) in the manufacturing sector, focusing on intrusion detection techniques and the potential of AI technology in Industry 4.0.
ARTIFICIAL INTELLIGENCE REVIEW
(2021)
Review
Multidisciplinary Sciences
Helene Ralimanana, Allison L. Perrigo, Rhian J. Smith, James S. Borrell, Soren Faurby, Mamy Tiana Rajaonah, Tianjanahary Randriamboavonjy, Maria S. Vorontsova, Robert S. C. Cooke, Leanne N. Phelps, Ferran Sayol, Niels Andela, Tobias Andermann, Andotiana M. Andriamanohera, Sylvie Andriambololonera, Steven P. Bachman, Christine D. Bacon, William J. Baker, Francesco Belluardo, Chris Birkinshaw, Stuart Cable, Nataly A. Canales, Juan D. Carrillo, Rosie Clegg, Colin Clubbe, Angelica Crottini, Gabriel Damasco, Sonia Dhanda, Daniel Edler, Harith Farooq, Paola de Lima Ferreira, Brian L. Fisher, Felix Forest, Lauren M. Gardiner, Steven M. Goodman, Olwen M. Grace, Thais B. Guedes, Jan Hackel, Marie C. Henniges, Rowena Hill, Caroline E. R. Lehmann, Porter P. Lowry, Lovanomenjanahary Marline, Pavel Matos-Maravi, Justin Moat, Beatriz Neves, Matheus G. C. Nogueira, Renske E. Onstein, Alexander S. T. Papadopulos, Oscar A. Perez-Escobar, Peter B. Phillipson, Samuel Pironon, Natalia A. S. Przelomska, Marina Rabarimanarivo, David Rabehevitra, Jeannie Raharimampionona, Fano Rajaonary, Landy R. Rajaovelona, Mijoro Rakotoarinivo, Amedee A. Rakotoarisoa, Solofo E. Rakotoarisoa, Herizo N. Rakotomalala, Franck Rakotonasolo, Berthe A. Ralaiveloarisoa, Myriam Ramirez-Herranz, Jean Emmanuel N. Randriamamonjy, Vonona Randrianasolo, Andriambolantsoa Rasolohery, Anitry N. Ratsifandrihamanana, Noro Ravololomanana, Velosoa Razafiniary, Henintsoa Razanajatovo, Estelle Razanatsoa, Malin Rivers, Daniele Silvestro, Weston Testo, Maria F. Torres Jimenez, Kim Walker, Barnaby E. Walker, Paul Wilkin, Jenny Williams, Thomas Ziegler, Alexander Zizka, Alexandre Antonelli
Summary: Madagascar's unique biota is facing intense threat from human activity, and the existing protected area network covers 10.4% of the land area. Overexploitation of biological resources and unsustainable agriculture are identified as the most prominent threats to Madagascar's biodiversity.
Article
Chemistry, Multidisciplinary
Maylis Orio, Dimitrios A. Pantazis
Summary: Quantum chemical approaches are a powerful tool in studying the properties and reactivity of metalloenzymes, particularly in the field of solar fuels research. These methods help in understanding the nature of catalytic intermediates, establishing structure-function correlations, elucidating functional principles, and unraveling key steps in reaction mechanisms.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biology
Samira A. Mohamed, Thomas Dubois, Abdelmutalab G. A. Azrag, Shepard Ndlela, Peter Neuenschwander
Summary: This review presents recent advances in classical biological control (CBC) of key horticultural insect pests using parasitoids in Africa. It outlines the key obstacles impeding CBC and the opportunities that could promote CBC in Africa. The review also provides brief highlights on recent scientific and technological advances related to CBC, including modeling, integrative taxonomy and molecular tools, and endosymbionts.
CURRENT OPINION IN INSECT SCIENCE
(2022)
Article
Economics
Eric Budish, Hannah Kettler, Scott Duke Kominers, Erik Osland, Canice Prendergast, Andrew A. Torkelson
Summary: The article describes and reviews the allocation process of the COVAX international vaccine collaboration, which aims to distribute vaccines equitably worldwide. It also discusses alternative market design approaches and provides suggestions for future global vaccine cooperation.
OXFORD REVIEW OF ECONOMIC POLICY
(2022)
Article
Immunology
Tanja Becker, Husni Elbahesh, Leslie A. Reperant, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus
Summary: Influenza vaccines have been available for over 80 years and have contributed significantly to reducing morbidity and mortality. However, limitations in their effectiveness persist due to antigenic evolution and production methods. Alternative approaches are being pursued to design and produce vaccines with broader and longer-lasting immune responses.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Poonam Dhindwal, Iryna Myziuk, Antonio Ruzzini
Summary: This forum discusses the important role of bacterial macrolide esterases in antibiotics, as well as their potential applications in agricultural systems and bioremediation efforts.
TRENDS IN MICROBIOLOGY
(2023)
Article
Computer Science, Hardware & Architecture
Jason Cong, Jason Lau, Gai Liu, Stephen Neuendorffer, Peichen Pan, Kees Vissers, Zhiru Zhang
Summary: The article evaluates the success of FPGA high-level synthesis technology in various application domains and discusses the challenges faced by the current technology and future research directions.
ACM TRANSACTIONS ON RECONFIGURABLE TECHNOLOGY AND SYSTEMS
(2022)
Article
Computer Science, Information Systems
Mayank Kumar Rusia, Dushyant Kumar Singh
Summary: This paper explores various types of face recognition techniques, the challenges they face, and the threats to face-biometric-based identity recognition. A new taxonomy is proposed to represent potential face identity threats, and state-of-the-art approaches are discussed to mitigate these threats. The paper also highlights research gaps and future opportunities in tackling facial identity threats.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Chemistry, Analytical
Melanie J. Bailey, Marcel de Puit, Francesco Saverio Romolo
Summary: Surface analysis techniques have great potential for applications in forensic science, particularly in the analysis of fingerprints, hair, drugs, explosives, and microtraces. Despite their promising results, operational deployment of these techniques faces challenges.
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Laura Isigkeit, Daniel Merk
Summary: Nuclear receptor modulation enables control of gene expression, making the 48 human nuclear receptors attractive targets for drug discovery. While some nuclear receptor ligands have been successfully used as drugs, there is still a lack of potent and well-characterized ligands for many orphan nuclear receptors. This review evaluates available nuclear receptor modulators and discusses the gaps in chemical tools for the understudied receptors, highlighting the need for new therapeutic avenues.
CHEMICAL COMMUNICATIONS
(2023)
Review
Medicine, Research & Experimental
Elmer V. Bernstam, Paula K. Shireman, Funda Meric-Bernstam, Meredith N. Zozus, Xiaoqian Jiang, Bradley B. Brimhall, Ashley K. Windham, Susanne Schmidt, Shyam Visweswaran, Ye Ye, Heath Goodrum, Yaobin Ling, Seemran Berapatre, Michael J. Becich
Summary: This paper examines the role of artificial intelligence in clinical and translational research, focusing on challenges, successes, failures, and opportunities. Analysis shows that the most common research topics in AI projects are nervous system and mental disorders, with supervised machine learning and deep learning being the most common computational approaches.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Review
Nanoscience & Nanotechnology
Reshma Vasantha Ramachandran, Ramray Bhat, Deepak Kumar Saini, Ambarish Ghosh
Summary: The concept of fantastic voyagers performing medical tasks within the human body has been present in popular culture for many decades but faces challenges in real-world application. Researchers are developing technologies such as micro-nanomotors to overcome these challenges, with obstacles including maneuverability, imaging, toxicity, and biodistribution.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)