Article
Cell Biology
Yimeng Hu, Jian Lv, Yu Fang, Qiang Luo, Yuan He, Lili Li, Mingxia Fan, Zhihua Wang
Summary: Crtc1(-/-) mice developed obesity due to abnormal expansion of white adipocytes, independent of changes in food intake or energy expenditure. These mice also showed increased insulin resistance and dyslipidemia, indicating a crucial role of Crtc1 in regulating lipid metabolism in adipose tissue.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Cho-Han Chiang, Yu-Cheng Chang, Shih-Syuan Wang, Yuan-Jen Chen, Xin Ya See, Chun-Yu Peng, Yuan Ping Hsia, Cho-Hsien Chiang, Cho-Hung Chiang, Cheng-Ming Peng
Summary: This retrospective cohort study investigated the impact of PPAR-gamma-activating ARBs on the survival of patients treated with immune checkpoint inhibitors (ICIs). The results showed that patients who used PPAR-gamma-activating ARBs had longer overall survival and progression-free survival, as well as lower disease progression and overall mortality rates compared to non-PPAR-gamma-ARB users. Patients who received PPAR-gamma-activating ARBs also had a higher clinical benefit rate.
Article
Biochemistry & Molecular Biology
Jung Seok Hwang, Jinwoo Hur, Won Jin Lee, Jun Pil Won, Hyuk Gyoon Lee, Dae-Seog Lim, Eunsu Kim, Han Geuk Seo
Summary: The study demonstrates that the upregulation of catalase through peroxisome proliferator-activated receptor delta (PPAR delta) is involved in the anti-hypertrophic activity of PPAR delta. Activation of PPAR delta by the specific ligand GW501516 significantly inhibits Ang II-induced hypertrophy and the generation of reactive oxygen species (ROS) in cardiomyocytes.
Review
Oncology
Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Summary: PPARs regulate cartilage homeostasis and reduce inflammation in OA, deficiency of PPARs may accelerate OA progression. PPAR agonists can inhibit catabolic and inflammatory factors synthesis, reducing cartilage lesions development in OA.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Review
Cell Biology
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo
Summary: This review discusses the roles of peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma in transcriptional regulation, energy metabolism, inflammation regulation, cellular development, and differentiation. PPAR signaling pathways play important roles in the development of viral, bacterial, and parasitic infectious diseases. The review also explores the potential therapeutic uses of PPAR agonists/antagonists in infectious disease treatment.
Article
Cell Biology
Hao-Xi Zhao, Zheng Zhang, Fang Hu, Qi-Feng Wei, Yong-Sheng Yu, Hao-Dong Zhao
Summary: Moderate swimming exercise has been found to improve renal function and structure, reduce renal injury and fibrosis in aged rats. It also has antioxidant and anti-inflammatory effects and exerts its benefits through activation of PPAR-alpha.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Michelle N. Rheault, Charles E. Alpers, Jonathan Barratt, Stewart Bieler, Pietro Canetta, Dong-Wan Chae, Gaia Coppock, Ulysses Diva, Loreto Gesualdo, Hiddo J. L. Heerspink, Jula K. Inrig, Gianna M. Kirsztajn, Donald Kohan, Radko Komers, Laura A. Kooienga, Kenneth Lieberman, Alex Mercer, Irene L. Noronha, Vlado Perkovic, Jai Radhakrishnan, William Rote, Brad Rovin, Vladimir Tesar, Hernan Trimarchi, James Tumlin, Muh Geot Wong, Howard Trachtman, DUPRO Steering Comm, DUPLEX Investigators
Summary: In the treatment of FSGS, sparsentan showed a better reduction in proteinuria compared to irbesartan. However, there were no significant differences in eGFR slope between the two groups at 108 weeks. Both sparsentan and irbesartan demonstrated similar safety profiles.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Iason Psilopatis, Kleio Vrettou, Eleni Nousiopoulou, Kostas Palamaris, Stamatios Theocharis
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, causing severe menstrual irregularities, skin conditions, and insulin resistance-associated health problems. Peroxisome proliferator-activated receptors (PPARs) have been investigated for their role in PCOS, but studies have reached contradictory conclusions about PPAR expression in PCOS. However, natural agents have shown promise as alternative treatments for PCOS. Overall, PPARs appear to play a significant role in PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jian Qu, Shengyu Tan, Xinyan Xie, Wenqiang Wu, Haihong Zhu, Hang Li, Xiaobo Liao, Jiaojiao Wang, Zhi-Ang Zhou, Song Huang, Qiong Lu
Summary: Dendrobium officinale polysaccharide (DOP) can improve obesity-associated insulin resistance and abnormal lipid metabolism through its activities on PPAR-gamma, reducing inflammation in the liver and adipose tissue, and showing potential therapeutic effects on obese mice with IR and lipid metabolism disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Xue-feng Yang, De-jing Shang
Summary: Cardiovascular disease events result from abnormalities in arteries and heart. Atherosclerosis is the main cause, associated with dyslipidemia and inflammation. Inhibition of macrophage differentiation and reduction of proinflammatory factors can alleviate atherosclerosis. Peroxisome proliferator-activated receptor α (PPARα) plays a key role in regulating triglyceride metabolism, lipid uptake, cholesterol efflux, and inflammatory signaling pathways. This review summarizes the role of PPARα in lipid metabolism and inflammation in atherosclerosis and discusses its potential as a therapeutic target.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Pei-Ying Pai, James K. S. Wong, Zhen-Yang Cui, Yi-Yuan Lin, Shin-Da Lee
Summary: This study investigated the effects of ARB on cardiac apoptosis in hypertensive rats and found that ARB may prevent cardiac apoptosis by suppressing the Fas/FasL-mediated and mitochondria-mediated apoptotic pathways and by activating the SIRT1/PGC-1 alpha pro-survival pathway in the heart.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Endocrinology & Metabolism
Toru Kusakabe, Ken Ebihara, Takeru Sakai, Licht Miyamoto, Daisuke Aotani, Yuji Yamamoto, Sachiko Yamamoto-Kataoka, Megumi Aizawa-Abe, Junji Fujikura, Kiminori Hosoda, Kazuwa Nakao
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2012)
Article
Endocrinology & Metabolism
Masaki Naito, Junji Fujikura, Ken Ebihara, Fumiko Miyanaga, Hideki Yokoi, Toru Kusakabe, Yuji Yamamoto, Cheol Son, Masashi Mukoyama, Kiminori Hosoda, Kazuwa Nakao
Article
Endocrinology & Metabolism
T. Kusakabe, H. Tanioka, K. Ebihara, M. Hirata, L. Miyamoto, F. Miyanaga, H. Hige, D. Aotani, T. Fujisawa, H. Masuzaki, K. Hosoda, K. Nakao
Article
Endocrinology & Metabolism
X. Rong, Y. Li, K. Ebihara, M. Zhao, J. Naowaboot, T. Kusakabe, K. Kuwahara, M. Murray, K. Nakao
Article
Endocrinology & Metabolism
Nobuko Yamada, Goro Katsuura, Yukari Ochi, Ken Ebihara, Toru Kusakabe, Kiminori Hosoda, Kazuwa Nakao
Article
Endocrinology & Metabolism
N. Yamada-Goto, G. Katsuura, Y. Ochi, K. Ebihara, T. Kusakabe, K. Hosoda, K. Nakao
JOURNAL OF NEUROENDOCRINOLOGY
(2012)
Article
Pharmacology & Pharmacy
X. Rong, Y. Li, K. Ebihara, M. Zhao, W. Aini, T. Kusakabe, M. Hirata, L. Miyamoto, M. Murray, K. Nakao
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2009)
Article
Urology & Nephrology
Takashige Kuwabara, Kiyoshi Mori, Masashi Mukoyama, Masato Kasahara, Hideki Yokoi, Yoko Saito, Tetsuro Yoshioka, Yoshihisa Ogawa, Hirotaka Imamaki, Toru Kusakabe, Ken Ebihara, Mitsugu Omata, Noriko Satoh, Akira Sugawara, Jonathan Barasch, Kazuwa Nakao
KIDNEY INTERNATIONAL
(2009)
Article
Endocrinology & Metabolism
Masanori Iwanishi, Ken Ebihara, Toru Kusakabe, Wen Chen, Jun Ito, Hiroaki Masuzaki, Kiminori Hosoda, Kazuwa Nakao
METABOLISM-CLINICAL AND EXPERIMENTAL
(2009)
Article
Endocrinology & Metabolism
Sadanori Okada, Chisayo Kozuka, Hiroaki Masuzaki, Shintaro Yasue, Takako Ishii-Yonemoto, Tomohiro Tanaka, Yuji Yamamoto, Michio Noguchi, Toru Kusakabe, Tsutomu Tomita, Junji Fujikura, Ken Ebihara, Kiminori Hosoda, Hiroshi Sakaue, Hiroyuki Kobori, Mira Ham, Yun Sok Lee, Jae Bum Kim, Yoshihiko Saito, Kazuwa Nakao
METABOLISM-CLINICAL AND EXPERIMENTAL
(2010)
Article
Endocrinology & Metabolism
Nozomi Kobayashi, Hiroaki Masuzaki, Tomohiro Tanaka, Sintaro Yasue, Takako Ishii, Tsutomu Tomita, Takashi Miyawaki, Toshiki Komeda, Yoshihiro Fukuda, Toru Kusakabe, Michio Noguchi, Junji Fujikura, Ken Ebihara, Masakazu Hirata, Kiminori Hosoda, Noriko Satoh, Masatoshi Nakajima, Yoshito Okabayashi, T. Shun Sato, Kazuwa Nakao
OBESITY RESEARCH & CLINICAL PRACTICE
(2009)
Article
Endocrinology & Metabolism
N. Arai, H. Masuzaki, T. Tanaka, T. Ishii, S. Yasue, N. Kobayashi, T. Tomita, M. Noguchi, T. Kusakabe, J. Fujikura, K. Ebihara, M. Hirata, K. Hosoda, T. Hayashi, H. Sawai, Y. Minokoshi, K. Nakao
Article
Endocrinology & Metabolism
Ken Ebihara, Toru Kusakabe, Masakazu Hirata, Hiroaki Masuzaki, Fumiko Miyanaga, Nozomi Kobayashi, Tomohiro Tanaka, Hideki Chusho, Takashi Miyazawa, Tatsuya Hayashi, Kiminori Hosoda, Yoshihiro Ogawa, Alex M. DePaoli, Masanori Fukushima, Kazuwa Nakao
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2007)
Article
Endocrinology & Metabolism
T Tanaka, H Masuzaki, K Ebihara, Y Ogawa, S Yasue, H Yukioka, H Chusho, F Miyanaga, T Miyazawa, M Fujimoto, T Kusakabe, N Kobayashi, T Hayashi, K Hosoda, K Nakao
METABOLISM-CLINICAL AND EXPERIMENTAL
(2005)