Article
Neurosciences
Dan-Dan Zhu, Guang Yang, Yue-Lin Huang, Ting Zhang, Ao-Ran Sui, Na Li, Wei-Heng Su, Hai-Lun Sun, Jing-Jing Gao, Michael Ntim, Rong-Xiao Guan, Ling-Ling Jin, Jian Yu, Zhi-Yong Huang, Tong-Hui Ma, Shao Li
Summary: This study developed a mouse model with depolymerized orthogonal arrays of particles (OAPs) to investigate the importance of OAP formation in Aquaporin-4 (AQP4). The results showed that the OAP structure of AQP4 plays a key role in its polarized expression in astrocytic endfeet processes at the blood-brain barrier. Manipulating the OAP formation of AQP4 may provide a new intervention strategy for cerebral cellular edema caused by stroke and traumatic brain injury.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yabin Ji, Qiang Gao, Yinzhong Ma, Fang Wang, Xixi Tan, Dengpan Song, Ruby L. C. Hoo, Zening Wang, Xin Ge, Hongjie Han, Fuyou Guo, Junlei Chang
Summary: A human IgG monoclonal antibody called L13 showed potential as a therapeutic approach for both ischemic and hemorrhagic stroke by selectively inhibiting MMP-9 activity and reducing brain tissue injury. Treatment with L13 improved neurological outcomes and attenuated BBB breakdown in mouse stroke models. The antibody also neutralized MMP-9 activity in stroke patients' sera and brain tissues, suggesting its clinical application.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Chao Song, Chao Gao, Zhenxin Wang
Summary: This study found that MMP-9 activation and BBB disruption are involved in CICI. Procyanidin may effectively alleviate the harmful effects of cisplatin.
Review
Pharmacology & Pharmacy
Macarena Sanchez-Navarro, Ernest Giralt
Summary: The blood-brain barrier is important for limiting drug delivery to the brain, but it also plays a crucial role in nutrient entrance. Peptide shuttles offer a promising strategy for increasing drug transport across the blood-brain barrier by utilizing its natural transport mechanisms. In recent years, the field of peptide shuttles has significantly evolved, with various classifications and sources being explored.
Article
Materials Science, Multidisciplinary
Guoliang Zhang, Xiangfei Liu, Weichang Xie, Can Hong, Yingying Xu, Wei Zhang, Siyu Zhao, Hongbo Xin, Xiaolei Wang
Summary: A study explored the use of beard nanoscale particles (BNPs) derived from young Asian males to load antidepressants and demonstrated therapeutic effects on depression. BNPs showed favorable photothermal conversion capability, prominent BBB permeability under near-infrared irradiation, reliable biocompatibility, and a pivotal role in redox equilibrium for scavenging ROS induced by depression. Additionally, behavioral and biochemical experiments confirmed significant depression-ameliorating effects in vivo.
APPLIED MATERIALS TODAY
(2021)
Article
Clinical Neurology
Junlin Lu, Jingyi Wang, Zhidong Lin, Guangchao Shi, Rong Wang, Yahui Zhao, Yuanli Zhao, Jizong Zhao
Summary: The study investigated the association between MMP-9 levels and phenotypes of moyamoya disease (MMD). Higher MMP-9 expression was found in adult MMD patients, especially in hemorrhagic-onset cases. Elevated serum MMP-9 level (>1,011 ng/ml) may serve as an independent risk predictor for hemorrhagic strokes in adult MMD patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Chemistry, Medicinal
Yamir Islam, Parinaz Ehtezazi, Andrew Cashmore, Elena Marinsalda, Andrew G. Leach, Christopher R. Coxon, Amos A. Fatokun, Darren W. Sexton, Iftikhar Khan, Georgios Zouganelis, James Downing, Stefano Pluchino, Muttuswamy Sivakumaran, Meritxell Teixido, Touraj Ehtezazi
Summary: The study investigated whether including MMP-9-sensitive sequences in brain-targeting nanoparticles could enhance BBB penetration during elevated MMP-9 levels, leading to increased transport across the BBB model when MMP-9 levels were elevated and the brain-targeting ligand was responsive to MMP-9.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Cell Biology
Chao Lin, Wei Wu, Hua Lu, Wentao Li, Zhongyuan Bao, Yingyi Wang, Lin Zhao, Tianwei Guo, Ning Cai, Zheng Li, Jing Ji, Lijun Hou, Yongping You, Ning Liu
Summary: Concussion can cause disruption of the blood-brain barrier through MMP-9, with the MMP-9 inhibitor GM6001 preventing the development of PD via the autophagy pathway.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Review
Neurosciences
Sylwia Pabian-Jewula, Marcin Rylski
Summary: This article discusses the relationship between the functional single nucleotide polymorphism (SNP) at position -1562C/T within the MMP-9 gene and the development of nervous system diseases. The functional polymorphism affects the activity of the MMP-9 gene promoter and thereby alters the expression of MMP-9. This can change the likelihood of disease occurrence and modify the course of certain brain diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Muyao Wu, Yating Gong, Lei Jiang, Min Zhang, Haiping Gu, Hui Shen, Baoqi Dang
Summary: Blood-brain barrier (BBB) damage is closely related to prognosis in patients with traumatic brain injury (TBI). This study found that upregulation of VEGF and MMP-9 in TBI may contribute to BBB disruption and nerve damage.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Medicine, General & Internal
Sneha Rathi, Jessica Griffith, Wenjuan Zhang, Wenqiu Zhang, Ju-Hee Oh, Surabhi Talele, Jann N. Sarkaria, William F. Elmquist
Summary: Brain tumours have a poor prognosis due to the challenges posed by the blood-brain barrier (BBB) in drug delivery. The heterogeneity of the blood-brain tumour barrier (BBTB) limits the success of relying on its disruption for effective drug concentrations in tumours. Therefore, designing drugs and delivery strategies to overcome the 'normal' BBB is crucial for treating brain tumours effectively.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ping Ma, Ning Huang, Jun Tang, Zunjie Zhou, Jing Xu, Yi Chen, Maoxin Zhang, Qin Huang, Yuan Cheng
Summary: The study shows that 9-PH effectively reduces cerebral edema by inhibiting the TRPM4 channel, reducing cytotoxic edema and preventing vasogenic edema. It also alleviates secondary brain injury by reducing inflammation and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Jamie Marino, Monique E. Maubert, Jill M. Lawrence, Brian Wigdahl, Michael R. Nonnemacher
Summary: The blood-brain barrier plays a crucial role in regulating the passage of molecules between the central nervous system and peripheral circulation. Repeat morphine dosing may not significantly affect the integrity of the blood-brain barrier.
Article
Nanoscience & Nanotechnology
Manju Sharma, Virendra Tiwari, Swati Chaturvedi, Muhammad Wahajuddin, Shubha Shukla, Jiban Jyoti Panda
Summary: This study developed self-fluorescent nanoparticles as a therapeutic system for Alzheimer's disease (AD), showing the ability to inhibit and disrupt the amyloid fibrils associated with AD. These nanoparticles were nontoxic to neural cells and protected neurons from cytotoxicity. Animal model experiments demonstrated that the nanoparticles improved memory in AD model rats. Overall, the nanoparticles showed promising potential as nanotheranostic agents for AD therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Jeong-Won Choi, Minwook Seo, Kyunghwan Kim, A-Ru Kim, Hakmin Lee, Hyung-Seok Kim, Chun Gwon Park, Seung Woo Cho, Joo H. Kang, Jinmyoung Joo, Tae-Eun Park
Summary: By using a human microphysiological system (MPS)-based SELEX method, a human BBB shuttle aptamer (hBS) with high efficiency in crossing the blood-brain barrier was successfully screened. The hBS demonstrated enhanced uptake efficiency in brain microvascular endothelial cells and brain cells, and showed high specificity and accumulation in the brain.
Review
Geriatrics & Gerontology
Tao Lv, Bing Zhao, Qin Hu, Xiaohua Zhang
Summary: The glymphatic system is a novel brain-wide perivascular transit network facilitating brain metabolic waste clearance, associated with neurological disorders and the pathophysiology of stroke.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Jianfei Lu, Qiyong Mei, Xianhua Hou, Anatol Manaenko, Lili Zhou, David S. Liebeskind, John H. Zhang, Yao Li, Qin Hu
Summary: Advancements in imaging techniques have expanded the treatment window for acute stroke, with the proposal of a tissue window providing a new approach for precision medicine in ischemic stroke. Neuroimaging plays a crucial role in defining a tissue window.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Jian-Song Zhang, Pin-Pin Hou, Shuai Shao, Anatol Manaenko, Zhi-Peng Xiao, Yan Chen, Bing Zhao, Feng Jia, Xiao-Hua Zhang, Qi-Yong Mei, Qin Hu
Summary: This study demonstrates that miR-455-5p could serve as a potential biomarker and therapeutic target for cerebral ischemia/reperfusion injury. It attenuates cerebral ischemia/reperfusion injury by inhibiting the expression of C-C chemokine receptor type 5 and reducing the neuroinflammatory response.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yuanyuan Gao, Yong Guo, Zackary D. Travis, Jiping Tang, Wen-Xiong Chen, John H. Zhang
Summary: The activation of MC1R with BMS-470539 attenuates oxidative stress and neuronal apoptosis in a neonatal HI rat model, improving neurological deficits. This effect is partially mediated by the MC1R/cAMP/PKA/Nurr1 signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Clinical Neurology
Zhi-Peng Xiao, Tao Lv, Pin-Pin Hou, Anatol Manaenko, Yuandong Liu, Yichao Jin, Li Gao, Feng Jia, Yang Tian, Peiying Li, John H. Zhang, Qin Hu, Xiaohua Zhang
Summary: The study revealed that protein lysine succinylation is altered after subarachnoid hemorrhage, and activation of Sirt5 helps restore mitochondrial metabolism and alleviate early brain injury.
Article
Biochemistry & Molecular Biology
Ivana Savic Azoulay, Xin Qi, Maya Rozenfeld, Fan Liu, Qin Hu, Tsipi Ben Kasus Nissim, Alexandra Stavsky, Michael X. Zhu, Tian-Le Xu, Israel Sekler
Summary: The research revealed that neuronal uptake of L-lactate leads to intracellular acidification, triggering H+ extrusion to activate ASIC1a channels, propagating Ca2+ signals to mitochondria to enhance respiration. L-isomer of lactate has a greater impact on ASIC1a compared to D-isomer, due to the preference of lactate transporters for L-lactate.
Article
Geriatrics & Gerontology
Li Gao, Fan Liu, Pin-Pin Hou, Anatol Manaenko, Zhi-Peng Xiao, Fei Wang, Tian-Le Xu, Qin Hu
Summary: Mitochondrial dysfunction is a major cause of neuronal death after stroke, and intercellular mitochondrial transfer shows promise as a potential therapeutic approach. Neurons release more mitochondria when exposed to challenges like acidosis, hydrogen peroxide, NMDA, or glutamate, which are then engulfed by adjacent astrocytes. This transfer may serve as a signaling mechanism to mediate the interaction between neurons and astrocytes.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Editorial Material
Endocrinology & Metabolism
Qin Hu, Jianfei Lu, Xiaohua Zhang, Ran Liu, Shao-Hua Yang
Summary: Researchers have reported a novel method for single-cell mitochondrial transplantation using a nanosyringe, which has a high success rate. The transferred mitochondria can fuse with host mitochondria and incorporate into the recipient genome, providing important insights into mitochondrial biology and stroke research.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Cell Biology
Jinwei Pang, Nathanael Matei, Jianhua Peng, Wen Zheng, Jing Yu, Xu Luo, Richard Camara, Ligang Chen, Jiping Tang, John H. Zhang, Yong Jiang
Summary: Delayed recanalization at day 3 postinfarct can significantly improve neurological outcomes after ischemic stroke. Macrophages play a critical role in this process by promoting angiogenesis and reducing neurodegeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Editorial Material
Geriatrics & Gerontology
Qingyuan Liu, Bing Zhao, Qin Hu, Shuo Wang, Chengcheng Zhu
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Junjia Tang, Yichao Jin, Feng Jia, Tao Lv, Anatol Manaenko, Lin-Feng Zhang, Zeyu Zhang, Xin Qi, Yajun Xue, Bin Zhao, Xiaohua Zhang, John H. Zhang, Jianfei Lu, Qin Hu
Summary: This study investigates the role of microglia efferocytosis in post-subarachnoid hemorrhage (SAH) inflammation. The findings suggest that recombinant Gas6 promotes microglia efferocytosis, reduces inflammation, and improves neurological deficits and blood-brain barrier breakdown in a mouse SAH model. These effects are partially dependent on the activation of Axl and Rac1 pathways.
TRANSLATIONAL STROKE RESEARCH
(2022)
Editorial Material
Neurosciences
Qin Hu, Yi Yang, Zonguo Guo, Prativa Sherchan
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Chensheng Le, Xin Hu, Lusha Tong, Xianghua Ye, Junyi Zhang, Jun Yan, Prativa Sherchan, John H. Zhang, Feng Gao, Jiping Tang
Summary: This study investigated the role of LAR in neuroinflammation after intracerebral hemorrhage (ICH) using a mouse model. The results showed that LAR contributed to neuroinflammation after ICH via the RhoA/IRS-1 pathway, and the inhibitor ELP may be a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation after ICH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters, Ian Galea
Summary: Sphingosine-1-phosphate (S1P) plays a role in the pathophysiology of neurological injury after aneurysmal subarachnoid haemorrhage (aSAH). The literature agrees that S1P increases in cerebrospinal fluid following aSAH and contributes to cerebral artery vasospasm. However, the role of S1P in the parenchyma is less clear, with conflicting studies suggesting both beneficial and harmful effects. This review provides a concise interpretation of the conflicting data and discusses the potential repurposing of S1P receptor modulators for aSAH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Q. Hu, X. Zhang
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
